A5046638917- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- Orthopedic Infections and Treatments
- Streptococcal Infections and Treatments
- Antibiotic Resistance in Bacteria
- Acne and Rosacea Treatments and Effects
- Antibiotic Use and Resistance
- Infectious Diseases and Tuberculosis
- Urinary Tract Infections Management
- Antibiotics Pharmacokinetics and Efficacy
- Antifungal resistance and susceptibility
- Dermatology and Skin Diseases
- Pneumonia and Respiratory Infections
- Reproductive tract infections research
- Oral Health Pathology and Treatment
- Herpesvirus Infections and Treatments
- Cardiac Valve Diseases and Treatments
- Infections and bacterial resistance
- Mycobacterium research and diagnosis
- Oral microbiology and periodontitis research
- Salivary Gland Disorders and Functions
- Transplantation: Methods and Outcomes
- Bacterial Infections and Vaccines
- Bartonella species infections research
Centre Hospitalier Universitaire de Nantes
2020-2024
Immunologie et Nouveaux Concepts en Immunothérapie
2024
Nantes Université
2020-2024
Inserm
2021-2024
Centre National de la Recherche Scientifique
2024
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2020
Hôpital Paris Saint-Joseph
2018
Abstract Background Dalbavancin is a lipoglycopeptide antibiotic with wide spectrum of activity against Gram-positive bacteria, including MDR isolates. Its pharmacokinetic properties and administration patterns could be useful for the treatment bone joint infections, especially prosthetic infections (PJIs). Introduction We report case an 80-year-old man who experienced acute periprosthetic infection his right total knee arthroplasty (TKA). A DAIR procedure was done tissue sampling, which...
The choice of the best probabilistic postoperative antibiotics in bone and joint infections (BJIs) is still challenging. Since implementation protocolized linezolid six French referral centers, linezolid-resistant multidrug-resistant Staphylococcus epidermidis (LR-MDRSE) strains were isolated patients with BJI. We aimed here to describe clinical, microbiological, molecular patterns associated these strains. All at least one intraoperative specimen positive for LR-MDRSE between 2015 2020...
ObjectivesThe empirical treatment of infective endocarditis is still debated. The aim this study was to compare the impact with antistaphylococcal penicillin (ASP) or cefazolin versus other treatments in methicillin-susceptible Staphylococcus aureus (MSSA) endocarditis.MethodsA post-hoc analysis a prospective cohort patients hospitalized French reference center MSSA conducted between 2013 and 2022. primary outcome duration bacteremia under treatment.ResultsOf 208 included, 101 (48.6%) were...
Abstract Objectives Staphylococcus epidermidis bone and joint infections (BJIs) on material are often difficult to treat. The activity of delafloxacin has not yet been studied S. in this context. aim study was assess its vitro compared with other fluoroquinolones, against a large collection clinical strains. Methods We selected 538 strains isolated between January 2015 February 2023 from six French teaching hospitals. One hundred fifty-two were ofloxacin susceptible 386 resistant....
In this multicentric study performed in 12 French hospitals, we reported that 26.9% (14/52) of the amoxicillin-clavulanate-resistant Proteus mirabilis isolates produced OXA-23 carbapenemase. We found an inhibition zone diameter <11 mm around amoxicillin-clavulanate disc was accurate screening cutoff to detect these producers. confirmed by whole-genome sequencing OXA-23-producers all belonged same lineage has been demonstrated disseminate or OXA-58 P. mirabilis.
Acne vulgaris is a chronic inflammatory dermatosis. Cutibacterium acnes plays crucial role in the acne pathophysiology. Recent works present evidence of C. growing as biofilm cutaneous follicles. This development currently considered one leading causes vivo persistence and resistance to antimicrobials used treat acne.
Abstract Background Cutibacterium acnes is an anaerobic bacterium mostly implicated in cutaneous and body-implant infections. Splenic abscess a rare entity C. abscesses have only exceptionally been reported. We describe spontaneous splenic immunocompetent man with no predisposing factors or identified portal of entry. His isolates were subjected to single-locus sequence typing (SLST) explore their genetic relatedness better understand this infection. Case presentation A was diagnosed on...
Aim: Meropenem–vaborbactam and delafloxacin activities were not assessed against Achromobacter spp. (Achr), Burkholderia cepacia complex (Bcc) Stenotrophomonas maltophilia (Smal). Methodology: A total of 106 Achr, 57 Bcc 100 Smal tested with gradient diffusion test meropenem–vaborbactam, comparators. Results: MIC50 4 μg/ml for 1 B. cepacia, 2 cenocepacia multivorans, 32 Smal. Delafloxacin 0.25 cenocepacia, 0.5 μg/m meropenem–vaborbactam MICs fourfold lower than meropenem 28.3% 77.2% 53.8%...
Abstract Although Candida spp are aerobic microorganisms, some strains, mainly glabrata, can be recovered from anaerobic blood culture vials. We assessed the contribution of vials for diagnosis candidemia, especially C. glabrata. conducted a multicenter retrospective study including eight university or regional hospitals. A single episode monomicrobial candidemia per patient was included September 1st, 2016, to August 31st, 2019. The characteristics all and sampled within 2 h before after...
Kingella kingae is a bacteria involved in developing arthritis children. Its diagnosis remains difficult. We report case for which new biomarker, calprotectin measured the synovial fluid, was strongly positive and specific molecular test only way to diagnose it specifically.
Infective endocarditis is a rare condition in humans and associated with high illness death rates. We describe case of infective caused by Staphylococcus succinus bacteria France. used several techniques for susceptibility testing this to determine the oxacillin profile.
Abstract Objectives Co-trimoxazole could be an alternative antibiotic to treat device-related bone and joint infection (BJI) but there are few published data about its efficacy safety in this complex scenario infection. The objective was compare the outcome of patients with BJI treated regimen including co-trimoxazole versus a without co-trimoxazole. Methods This multicentre case–control study included consecutive adult diagnosed BJI. Each patient receiving group matched two control...
Bacterial vaginosis (BV) is the most common cause of abnormal vaginal discharge. BV represents a dysbiosis with acquisition diverse community anaerobic bacteria and reduction in lactobacilli burden. Our objective was to evaluate Aptima assay kit for diagnosis BV. From May August 2019, we enrolled outpatients inpatients, including nonpregnant women above 18 symptoms, consulting at Nantes University hospital. The measures loads Gardnerella vaginalis, Atopobium vaginae, Lactobacillus species...