A5037442831- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Hip disorders and treatments
- Bone and Joint Diseases
- Shoulder Injury and Treatment
- Hip and Femur Fractures
- Bone health and osteoporosis research
- Shoulder and Clavicle Injuries
- Bone health and treatments
- Infectious Diseases and Tuberculosis
- Bone fractures and treatments
- Bone Metabolism and Diseases
- Antimicrobial Resistance in Staphylococcus
- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Antibiotics Pharmacokinetics and Efficacy
- Orthopedic Surgery and Rehabilitation
- Antibiotic Resistance in Bacteria
- Nerve Injury and Rehabilitation
- Antifungal resistance and susceptibility
- Musculoskeletal Disorders and Rehabilitation
- Periodontal Regeneration and Treatments
- Foot and Ankle Surgery
- Sarcoma Diagnosis and Treatment
Nantes Université
2020-2025
Centre Hospitalier Universitaire de Nantes
2020-2025
Inserm
2021-2025
Centre d'Investigation Clinique de Nantes
2024
RMeS - Regenerative Medicine and Skeleton
2024
Centre National de la Recherche Scientifique
2010-2022
Laboratoire de Biologie, Bioingéniérie et Bioimagerie ostéoarticulaire
2011-2022
Assistance Publique – Hôpitaux de Paris
2006-2021
Hôpital Ambroise-Paré
2021
Université Paris-Saclay
2021
During a period of 25 years (1977 to 2001), 13 fractures an alumina component were recorded retrospectively. the same period, approximately 5500 components implanted (3300 with all-alumina bearings and 1200 alumina-on-polyethylene). These events occurred in seven women six men, mean age 59 weight 71 kg. There eight femoral head five socket component. Three clearly related trauma (two one fracture head) two abnormal design (one 22-mm extra-long neck). Five without any rational explanation,...
Abstract Wear particles generated with use of total joint replacements incite a chronic macrophage‐mediated inflammatory reaction, which leads to implant failure. Macrophage activation may be polarized into two states, an M1 proinflammatory state dominating alternatively activated M2 anti‐inflammatory state. We hypothesized that IL‐4, activator macrophages, could modulate polyethylene (PE) particle‐induced osteolysis in experimental murine model. Four animal groups included (a) calvarial...
Normal usage of total joint replacements results in the production wear debris and other byproducts. In particular, polyethylene particles are heavily involved stimulation local systemic biological reactions resulting chronic inflammation, periprosthetic bone resorption (osteolysis), and, eventually, implant loosening. As sentinels innate immune system, cells monocyte/macrophage lineage initiate inflammatory cascade that leads to osteolysis. The processes complex, based on unique properties...
Treatment of critical size bone defects is challenging. Recent studies showed that the cytokine stromal cell-derived factor 1 alpha (SDF-1α) has potential to improve regenerative effect low morphogenetic protein 2 (BMP-2) concentrations. The goal this study was demonstrate combined SDF-1α and BMP-2 on regeneration stem cell recruitment using a femoral defect model. A total 72 mice were randomized six groups. External fixators implanted onto right femur each mouse 3 mm created. Depending...
Abstract Background Dalbavancin is a lipoglycopeptide antibiotic with wide spectrum of activity against Gram-positive bacteria, including MDR isolates. Its pharmacokinetic properties and administration patterns could be useful for the treatment bone joint infections, especially prosthetic infections (PJIs). Introduction We report case an 80-year-old man who experienced acute periprosthetic infection his right total knee arthroplasty (TKA). A DAIR procedure was done tissue sampling, which...
Macrophages derive from human embryonic and fetal stem cells bone marrow-derived blood monocytes. They play a major homeostatic role in tissue remodeling maintenance facilitated by apoptotic "eat me" opsonins like CRP, serum amyloid P, C1q, C3b, IgM, ficolin, surfactant proteins. Three subsets of monocytes, classic, intermediate, nonclassic, are mobilized transmigrate to tissues. Implant-derived wear particles opsonized danger signals regulate macrophage priming, polarization (M1, M2, M17,...
Alumina-on-alumina bearings in THR may, theory, provide an effective answer to osteolysis young patients with ON of the femoral head. The purpose this retrospective study was report long-term results a series 52 consecutive alumina THAs (41 patients) done for ON. mean age at surgery 41 years (range, 22-79 years). Cemented stems 32-mm head were used. Plain cups used and either cemented (39 hips) or press-fit (13 hips). No lost followup. Sixteen hips have been revised. Aseptic loosening socket...
Abstract Aseptic loosening secondary to particle‐associated periprosthetic osteolysis remains a major cause of failure total joint replacements (TJR) in the mid‐ and long term. As sentinels innate immune system, macrophages are central recognition initiation inflammatory cascade, which results activation bone resorbing osteoclasts. Toll‐like receptors (TLRs) involved pathogen‐associated molecular patterns danger‐associated patterns. Experimentally, polymethylmethacrylate polyethylene (PE)...
Postmenopausal osteoporosis may modulate bone response to wear debris. In this article, we evaluate the influence of oestrogen deficiency on experimental particle-induced osteolysis. Polyethylene (PE) particles were implanted onto calvaria normal controls, sham-ovariectomized (OVX), OVX mice and supplemented with (OVX+E). After 14 days, seven skulls per group analyzed using a high-resolution micro-computed tomography (micro-CT) histomorphometry, for tartrate-specific alkaline phosphatase....
The choice of the best probabilistic postoperative antibiotics in bone and joint infections (BJIs) is still challenging. Since implementation protocolized linezolid six French referral centers, linezolid-resistant multidrug-resistant Staphylococcus epidermidis (LR-MDRSE) strains were isolated patients with BJI. We aimed here to describe clinical, microbiological, molecular patterns associated these strains. All at least one intraoperative specimen positive for LR-MDRSE between 2015 2020...
Limited pharmacokinetics data support dalbavancin long-term use in off-label indications and the optimal dosing regimen is debated. We aimed to describe concentrations an observational retrospective multicentre study.
Open repair of full-thickness tears the rotator cuff generally improves function, although anatomic failures are not uncommon. We asked whether presence or absence an influenced outcomes. retrospectively analyzed 47 patients (49 shoulders) treated by open proximalized reinsertion supraspinatus tendon for chronic retracted detachment. The mean age at time surgery was 59 years. At a minimum 60-month followup (mean, 87 months; range, 60-133 months), we observed improvement in age- and...
Background Repair of cuff tears involving rotator interval reportedly improves function. However, it is unclear whether successful repair prevents shoulder degenerative changes. Questions/purposes Therefore, we (1) documented the minimal 4-year function patients who underwent open surgical for tears; (2) evaluated repaired tendon healing with postoperative MRI; and (3) sought to determine influence on muscular glenohumeral joint Methods We retrospectively analyzed 22 (23 shoulders) treated...