A5031144640- Bone health and osteoporosis research
- Bone and Dental Protein Studies
- Medical Imaging Techniques and Applications
- Orthopaedic implants and arthroplasty
- dental development and anomalies
- Bone Metabolism and Diseases
- Bone health and treatments
- Bone and Joint Diseases
- Radiomics and Machine Learning in Medical Imaging
- Dental Radiography and Imaging
- Medical Imaging and Analysis
- Advanced X-ray and CT Imaging
- Nutrition and Health in Aging
- Digital Imaging in Medicine
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Adipose Tissue and Metabolism
- Mesenchymal stem cell research
- Connective tissue disorders research
- Cardiovascular Disease and Adiposity
- Orthodontics and Dentofacial Orthopedics
- Body Contouring and Surgery
- Hip and Femur Fractures
- Neurotransmitter Receptor Influence on Behavior
- Ubiquitin and proteasome pathways
Inserm
2006-2014
Université d'Orléans
2014
Sorbonne Paris Cité
2011-2013
Université Paris Cité
2011-2013
Délégation Paris 5
2011-2012
Laboratoire Pluridisciplinaire de Recherche en Ingénierie des Systèmes, Mécanique et Energétique
2009-2011
Centre hospitalier universitaire d'Orléans
2008-2009
Hôpital La Porte Verte
2007
Hôpital de la Conception
2006
Laboratoire d'Informatique et d'Automatique pour les Systèmes
2006
To use standard radiographs to determine which combination of co-occurrence textural parameters, geometric measurements, and cortical thickness measurements from femur provided the best estimate femoral failure load compare these with total hip dual-energy x-ray absorptiometry bone mineral density (BMD) evaluation.Digital 40 pairs excised femurs (24 women, 16 men; mean age, 82 years + or - 12 [standard deviation]) were obtained. Regions interest in neck, greater trochanter, intertrochanteric...
Upon in vitro induction or vivo implantation, the stem cells of dental pulp display hallmarks odontoblastic, osteogenic, adipogenic neuronal cells. However, whether these phenotypes result from genuine multipotent coexistence distinct progenitors is still an open question. Furthermore, determining a single cell-derived progenitor capable undergoing differentiation cascade leading to tissue repair situ important for development cell therapy strategies. Three clonal precursor lines (A4, C5,...
Postmenopausal osteoporosis may modulate bone response to wear debris. In this article, we evaluate the influence of oestrogen deficiency on experimental particle-induced osteolysis. Polyethylene (PE) particles were implanted onto calvaria normal controls, sham-ovariectomized (OVX), OVX mice and supplemented with (OVX+E). After 14 days, seven skulls per group analyzed using a high-resolution micro-computed tomography (micro-CT) histomorphometry, for tartrate-specific alkaline phosphatase....
Purpose: Hip fracture is a serious health problem and textural methods are being developed to assess bone quality. The authors aimed perform analysis at femur on high‐resolution digital radiographs compared three‐dimensional (3D) microarchitecture comparatively mineral density. Methods: Sixteen cadaveric femurs were imaged with an x‐ray device using C‐MOS sensor. One 17 mm square region of interest (ROI) was selected in the femoral head (FH) one great trochanter (GT). Two‐dimensional (2D)...
This paper presents a novel approach for vision-based control of the end-effector parallel mechanisms. It is based on metrological redundancy paradigm, which simplifies their kinematic models by introducing additional proprioceptive sensors. By observing mechanism legs, vision replaces advantageously these sensors delivering, in Cartesian frame, an exteroceptive measurement internal state mechanism. Formally, latter expressed original concept kinematics Based it, derived that visually...
Fibromodulin (Fmod) is a keratan sulfate small leucine-rich proteoglycan which enriched in bones and teeth. In order to determine its functions on bone tooth mineralization we characterized the phenotype of Fmod-deficient (Fmod-KO) mice using new-generation microfocus computerized tomography system (micro-CT) software allowing advanced visualization 3-D data. Three-week-old 10- week-old Fmod-KO mandibles teeth were compared with those age-matched wild-type (WT) mice. both young mature...
Structured Abstract Objectives To determine the role of Msx2 in craniofacial morphology and growth, we used a mouse model performed quantitative morphological characterization −/− +/− phenotype using 2D cephalometric analysis applied on micrographs. Materials Methods Forty‐four three‐and‐a‐half‐month‐old female CD 1 mice were divided into following three groups: +/+ (n = 16), 12). Profile radiographs scanned. Modified was to compare groups. Results Compared with wild‐type mice, mutant...
Postmenopausal osteoporosis is a common disorder that results from increased osteoclastic activity caused by estrogen deficiency. Whether postmenopausal bone remodeling can alter the response to particulate debris unknown. The purpose of this study was evaluate polyethylene particles in an ovariectomized murine model. Polyethylene were implanted onto calvaria seven control mice and (OVX) mice, as compared with sham-operated OVX mice. Calvaria harvested after 14 days. Skulls analyzed...
The objective of this study was to explore Laws' masks as a new application texture analysis characterise bone micro-architecture and check its dependence from the spatial resolution. method is based on that aim filter images. From each mask, classical statistical parameters can be calculated. Our performed 114 women with osteoporotic fractures 182 age-matched healthy post menopausal women. For all subjects radiographs were obtained calcaneus high-resolution X-ray device. mineral density...
Harichane Y, Dimitrova‐Nakov S, Marchadier A, Collet C, Baudry Vidal Kamoun‐Goldrat Kellermann O, Goldberg M. Enamel alterations in serotonin 2B receptor knockout mice. Eur J Oral Sci 2011; 119 (Suppl. 1): 177–184. © 2011 The role of the (5‐HT R) enamel formation and mineralization was explored adult 5HT R (KO) mice compared with wild‐type (WT) In molar, quantitative data obtained by micro‐computed tomography imaging showed that overall volume layer firmly reduced KO Defective ascertained...
The continuously growing rodent incisor is a widely used model to investigate odontogenesis and mineralized tissue formation. This study focused on evaluating the mouse mandibular as an experimental biological tool for analyzing in vivo capacity of odontoblast-like progenitors or bioactive molecules contribute reparative dentinogenesis. We describe here surgical procedure allowing direct access forming part dental pulp Amelogenin peptide A+4 adsorbed agarose beads, progenitor cells were...
In obese humans CT imaging is a validated method for follow up studies of adipose tissue distribution and quantification visceral subcutaneous fat. Equivalent methods in murine models obesity are still lacking. Current small animal micro-CT involves long-term X-ray exposure precluding longitudinal studies. We have overcome this limitation by using human medical which allows very fast 3D (2 sec) minimal radiation exposure. This work presents novel fitted to vivo investigations mice model...
Research on bone and teeth mineralization in animal models is critical for understanding human pathologies. Genetically modified mice represent highly valuable the study of osteo/dentinogenesis defects osteoporosis. Current investigations dental skeletal phenotype use destructive time consuming methods such as histology scanning microscopy. Micro-CT imaging quicker provides high resolution qualitative phenotypic description. However reliable quantification processes mouse are still lacking....
Introduction Osteogenesis imperfecta (OI) is a human genetic disorder of increased bone fragility and low mass. Severity varies widely, ranging from intrauterine fractures perinatal lethality to very mild forms without fractures. There variable association typical extra skeletal manifestations with the disorder, including blue sclera, dentinogenesis imperfecta, hyperlaxity ligaments skin, hearing impairment presence Wormian bones on skull radiography1. The most widely used classification OI...