A5035337261- Vector-borne infectious diseases
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- Infective Endocarditis Diagnosis and Management
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Viral Infections and Vectors
- Medical and Health Sciences Research
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Toxin Mechanisms and Immunotoxins
- Vector-Borne Animal Diseases
- Infectious Diseases and Mycology
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Neurological diseases and metabolism
- Medical Practices and Rehabilitation
- Infections and bacterial resistance
- Orthopedic Infections and Treatments
- Health and Medical Studies
- Insect and Pesticide Research
- Genital Health and Disease
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
Université de Strasbourg
2014-2024
Hôpitaux Universitaires de Strasbourg
2015-2024
Goethe University Frankfurt
2022
University College Dublin
2022
Génétique Moléculaire Génomique Microbiologie
2021
Institut de Virologie
2015-2021
Clinical Research Center Kiel
2006-2016
Inserm
2008-2015
Biology of Infection
2015
Institut de Recherche pour le Développement
2015
To estimate the cumulative incidence rate (CIR) of Chikungunya virus (CHIKV)-associated CNS disease during La Réunion outbreak, and assess burden patient outcome after 3 years.CHIKV-associated was characterized retrospectively in a cohort patients with positive CHIKV reverse transcriptase PCR or anti-CHIKV immunoglobulin M antibodies CSF fulfilling International Encephalitis Consortium criteria for encephalitis encephalopathy. Neurologic sequelae were assessed years.Between September 2005...
The aim of this study was to compare the in vitro susceptibility Klebsiella pneumoniae, Pseudomonas aeruginosa and Stenotrophomonas maltophilia three fluoroquinolones. minimum inhibitory concentrations (MICs) ciprofloxacin, levofloxacin moxifloxacin were examined by E-test® for a total 40 K. pneumoniae strains, S. strains P. strains. Then, bactericidal activity these fluoroquinolones investigated on five each bacterial species means time-kill curves. For aeruginosa, distance measured MIC...
The use of matrix-assisted laser desorption ionization-time flight mass spectrometry (MALDI-TOF MS) for staphylococcal identification is now considered routine in laboratories compared with the conventional phenotypical methods previously used. We verified its microbiological relevance identifying main species coagulase-negative staphylococci (CoNS) by randomly selecting 50 isolates. From 1 January 2007 to 31 August 2008, 12,479 were isolated phenotypic methods, which 4,594 identified as...
Abstract Background Achromobacter spp. are opportunistic pathogens, mostly infecting immunocompromised patients and with cystic fibrosis (CF) considered as difficult-to-treat pathogens due to both intrinsic resistance the possibility of acquired antimicrobial resistance. Species identification remains challenging leading imprecise descriptions in each taxon. Cefiderocol is a broad-spectrum siderophore cephalosporin increasingly used management infections for which susceptibility data remain...
Tick saliva has potent immunomodulatory properties. In arthropod-borne diseases, this effect is largely used by microorganisms to increase their pathogenicity and evade host immune responses. We show that in Lyme borreliosis, tick salivary gland extract a protein, Salp15, inhibit vitro keratinocyte inflammation induced Borrelia burgdorferi sensu stricto or the major outer surface lipoprotein of Borrelia, OspC. Chemokines (interleukin-8 [IL-8] monocyte chemoattractant protein 1 [MCP-1])...
In Lyme borreliosis, the skin is key site of bacterial inoculation by infected tick, and cutaneous manifestations, erythema migrans acrodermatitis chronica atrophicans. We explored role fibroblasts, resident cells dermis, in development disease. Using microarray experiments, we compared inflammation fibroblasts induced three strains Borrelia burgdorferi sensu stricto isolated from different environments stages disease: N40 (tick), Pbre (erythema migrans) 1408 (acrodermatitis atrophicans)....
ObjectivesIsoniazid-monoresistant tuberculosis (HR-TB) is the most prevalent form of drug-resistant TB worldwide and in France associated with poorer treatment outcomes compared drug-susceptible (DS-TB). The objective this study was to determine characteristics HR-TB patients compare safety for DS-TB.MethodsWe performed a case-control multicenter identify risk factors between DS-TB patients.ResultsCharacteristics 99 diagnosed treated university hospitals Paris, Lille, Caen Strasbourg were...
We investigated the epidemiological, clinical, microbiological and genetic characteristics of linezolid-resistant (LZR) Staphylococcus capitis isolates from French ICUs, compared them with LZR S. other European countries.All were subjected to antimicrobial susceptibility testing (AST) presence cfr optrA genes as well mutations in 23S rRNA ribosomal proteins using specific PCR sequencing. The relationship between was PFGE WGS. Epidemiological data concerning collected retrospectively...
In Lyme borreliosis, the skin is key site for bacterial inoculation by infected tick and cutaneous manifestations. We previously showed that different strains of Borrelia burgdorferi sensu stricto isolated from clinical stages borreliosis (erythema migrans, acrodermatitis chronica atrophicans) elicited a very similar transcriptional response in normal human dermal fibroblasts. this study, using whole transcriptome microarray chips, we aimed to compare fibroblasts stimulated 3 lato belonging...
Nonrandom distribution of hepatitis C virus (HCV) quasispecies (compartmentalization between blood plasma and leukocytes) suggests the presence HCV leukotropic variants. compartmentalization in setting liver transplantation (LT) is poorly understood. To study variants, we investigated evolution after immunosuppression transplant recipients.Plasma peripheral mononuclear cell (PBMC) samples were collected from 5 recipients before LT. We used clone sequencing to analyze hypervariable region 1...
Abstract Background The new definitions of antimicrobial susceptibility categories proposed by EUCAST in 2020 require the definition standard and high dosages antibiotic. For injectable β-lactams, have been for short-infusion regimens only. Objectives To evaluate β-lactams administered prolonged infusion (PI) continuous (CI). Methods Monte Carlo simulations were performed seven β-lactams: aztreonam, cefepime, cefotaxime, cefoxitin, ceftazidime, piperacillin temocillin. Various dosage based...
Lyme borreliosis in humans results a range of clinical manifestations, thought to be partly due differences the pathogenicity infecting strain. This study compared European human strains Borreliella afzelii (previously named Borrelia afzelii) using multilocus sequence typing (MLST) determine their spatial distribution across Europe and establish whether there are associations between B. genotypes specific manifestations borreliosis. For this purpose, was performed on 63 strains, data further...
Abstract Background PCRs targeting 16S ribosomal DNA (16S PCR) followed by Sanger’s sequencing can identify bacteria from normally sterile sites and complement standard analyzes, but they are expensive. We conducted a retrospective study in the Strasbourg University Hospital to assess clinical impact of PCR on patients’ treatments according different sample types. Methods From 2014 2018, 806 samples were processed, 191 those positive. Results Overall, test impacted treatment 62 patients...
Abstract Background Recent studies report very low adherence of practitioners to ATS/IDSA recommendations for the treatment nontuberculous mycobacteria pulmonary disease (NTM-PD), as well a great variability practices. Type management could impact prognosis. Methods To evaluate and prognosis patients with NTM-PD cases respect ATS recommendations, we conducted multicenter retrospective cohort study (18 sentinel sites distributed throughout France), over period six years. We collected...