A5019628589- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Thyroid Disorders and Treatments
- Chemical Reactions and Isotopes
- Pneumocystis jirovecii pneumonia detection and treatment
- Neuroendocrine regulation and behavior
- Human Health and Disease
- Antibiotic Resistance in Bacteria
- Herpesvirus Infections and Treatments
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Enzyme function and inhibition
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pneumonia and Respiratory Infections
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Blood groups and transfusion
- Electrolyte and hormonal disorders
- Muscle and Compartmental Disorders
- Cancer, Lipids, and Metabolism
- Microbial infections and disease research
- Toxoplasma gondii Research Studies
- Hemiptera Insect Studies
Assistance Publique – Hôpitaux de Paris
2014-2023
Sorbonne Université
2013-2023
Centre d'Immunologie et des Maladies Infectieuses
2020-2023
Inserm
2016-2023
Pitié-Salpêtrière Hospital
2014-2021
Hôpitaux Universitaires de Strasbourg
2021
CNR de la Résistance aux Antibiotiques
2021
Université Paris Cité
2016-2020
Hôpital Lariboisière
2020
Hôpital de la Croix-Rousse
2018
Klebsiella pneumoniae is a common cause of sepsis and particularly associated with healthcare-associated infections. New strategies are needed to prevent or treat infections due the emergence multi-drug resistant K. pneumoniae. The goal this study was determine global diversity distribution O (lipopolysaccharide) K (capsular polysaccharide) antigens on large (>500) collection strains isolated from blood inform vaccine development efforts. A total 645 isolates were collected patients...
High-dose isoniazid is recommended to treat multidrug-resistant tuberculosis (MDR TB). Among 958 MDR TB isolates identified in France during 2008-2022, 93.1% exhibited high-level resistance, and molecular testing showed limited diagnostic accuracy predicting resistance. Clinicians should reconsider using high-dose treatment because of suboptimal effect toxicity concerns.
The pathogenesis of diabetic peripheral neuropathy remains uncertain and nonenzymatic glycoxidation is one the contributing mechanisms. aim this study was to assess respective relationship with glycoxidation, compared other identified risk factors, in patients type 2 diabetes.We included 198 diabetes high for vascular complications. Circulating concentrations three advanced glycation end products (carboxymethyllysine, methyl-glyoxal-hydroimidazolone-1, pentosidine) their soluble receptor...
Cancer cell killing might be achieved by the combined use of available drugs. Statins are major anti-hypercholesterolemia drugs, which also trigger apoptosis many cancer types, while docetaxel is a potent microtubule-stabilising agent. Here, we looked at effects lovastatin and in cells. Whole transcriptome microarrays HGT-1 gastric cells demonstrated that strongly suppressed expression genes involved division, had very little transcriptional effects. Both drugs triggered apoptosis, their...
The GeneLEAD VIII (Diagenode, Belgium) is a new, fully automated, sample-to-result precision instrument for the extraction of DNA and PCR detection Mycobacterium tuberculosis complex (MTBC) directly from clinical samples. Deeplex Myc-TB ® assay (Genoscreen, France) diagnostic kit based on deep sequencing 24-plexed amplicon mix allowing simultaneously resistance to 13 antituberculous (antiTB) drugs determination spoligotype. We evaluated performance strategy combining both mentioned tools...
Abstract Background Treatment of multidrug-resistant (MDR) tuberculosis with linezolid is characterized by high rates adverse events. Evidence on therapeutic drug monitoring to predict toxicity scarce. This study aimed evaluate the association trough concentrations severe toxicity. Methods We retrospectively assessed consecutive patients started for MDR between 2011 and 2017. The primary outcome was mitochondrial (SMT) due linezolid, defined as neurotoxicity or myelotoxicity leading...
Context: Calcification of the arterial wall in diabetes contributes to occlusive process occurring below knee. The osteoprotegerin (OPG)/receptor activator nuclear factor κB ligand (RANKL) system is suspected be involved calcification process. Objective: aim study was investigate whether there a link between type 2 and 1) conventional cardiovascular risk factors, 2) serum RANKL OPG levels, 3) neuropathy. Patients Methods: We objectively scored, cross-sectional study, infrapopliteal vascular...
Abstract Background The resistance to all aminoglycosides (AGs) conferred by 16S rRNA methyltransferase enzymes (16S-RMTases) is a major public health concern. Objectives To characterize the genotype, its genetic environment and plasmid support, phylogenetic relatedness of 16S-RMTase-producing Escherichia coli from France. Methods We screened 137 E. isolates resistant clinically relevant AGs nine Parisian hospitals for 16S-RMTases. WGS was performed on clinical with high-level AG (MIC ≥256...
ObjectivesIsoniazid-monoresistant tuberculosis (HR-TB) is the most prevalent form of drug-resistant TB worldwide and in France associated with poorer treatment outcomes compared drug-susceptible (DS-TB). The objective this study was to determine characteristics HR-TB patients compare safety for DS-TB.MethodsWe performed a case-control multicenter identify risk factors between DS-TB patients.ResultsCharacteristics 99 diagnosed treated university hospitals Paris, Lille, Caen Strasbourg were...
The Clinical and Laboratory Standards Institute recommends the use of Mueller Hinton (MH) medium to perform drug susceptibility testing (DST) Mycobacterium avium complex (MAC) using microdilution method. For MAC, there has been no study on impact media determination minimum inhibitory concentrations (MICs) antibiotics other than clarithromycin. This aimed at determining two used for DST MAC augmenting number pertinent MICs species encountered in clinical practice. treatment infections were...
Here, we report the development and key features of first external quality assessment (EQA) scheme for Mycobacterium tuberculosis whole-genome sequencing (WGS). The results four rounds (2017 to 2020) implementation within European reference laboratories network (ERLTB-Net-2) are presented discussed. EQA panels comprising 10 genomic DNAs were distributed ERLTB-Net 2 volunteering participate in this exercise. Since 2018, five FASTQ files added better assess dry WGS processes, 2020, three...
We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time ultimately were not predictive treatment outcome. This observation highlights limits current genotypic methods for detection resistance.
Ethionamide (ETH) is a second-line antituberculosis drug. ETH resistance (ETH-R) mainly related to the mutations of monooxygenase-activating (EthA), target (InhA), and inhA promoter. Nonetheless, diagnosing ETH-R still challenging. We assessed strategy used for detecting at French National Reference Center Mycobacteria in 497 MDR-TB isolates received from 2008 2016. The genotypic ETH's detection was performed by sequencing ethA, ethR, ethA-ethR intergenic region, promoter multidrug-resistant...
Journal Article Improved acid tolerance of a recombinant strain Escherichia coli expressing genes from the acidophilic bacterium Oenococcus oeni Get access F. Morel, Morel Laboratoire de Microbiologie, Université Bourgogne, Dijon, France Search for other works by this author on: Oxford Academic Google Scholar Delmas, Delmas M.‐P. Jobin, Jobin C. Diviès, Diviès J. Guzzo Dr Guzzo, UMR INRA, E.N.S.B.A.N.A., 1, esplanade Erasme, F‐21000 (e‐mail: jguzzo@u‐bourgogne.fr). Letters in Applied...