A5006366392- Pregnancy and preeclampsia studies
- Pharmacogenetics and Drug Metabolism
- Birth, Development, and Health
- Global Maternal and Child Health
- Growth Hormone and Insulin-like Growth Factors
- Food Security and Health in Diverse Populations
- HIV/AIDS Research and Interventions
- Global Public Health Policies and Epidemiology
- Health disparities and outcomes
- Healthcare Systems and Reforms
- Child Nutrition and Water Access
- Academic Publishing and Open Access
- Nitric Oxide and Endothelin Effects
- Diet and metabolism studies
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Sex work and related issues
- Adolescent Sexual and Reproductive Health
- HIV, Drug Use, Sexual Risk
- Coenzyme Q10 studies and effects
- Metabolism, Diabetes, and Cancer
- Pregnancy and Medication Impact
- Hepatitis B Virus Studies
- Hepatitis C virus research
Universidad San Francisco de Quito
2016-2025
Charles Darwin Foundation
2019-2022
Pontificia Universidad Católica del Ecuador
2018-2020
Central University of Ecuador
2004-2017
Hospital Gineco Obstétrico Isidro Ayora
2003
University College London
1998-2002
Wolfson Foundation
1999-2001
Universitat de València
1998
Klebsiella pneumoniae is a common cause of sepsis and particularly associated with healthcare-associated infections. New strategies are needed to prevent or treat infections due the emergence multi-drug resistant K. pneumoniae. The goal this study was determine global diversity distribution O (lipopolysaccharide) K (capsular polysaccharide) antigens on large (>500) collection strains isolated from blood inform vaccine development efforts. A total 645 isolates were collected patients...
Preprints are preliminary reports that have not been peer-reviewed. In December 2019, a novel coronavirus appeared in China, and since then, scientific production, including preprints, has drastically increased. this study, we intend to evaluate how often preprints about COVID-19 were published scholarly journals cited.We searched the iSearch portfolio identify all related posted on bioRxiv, medRxiv, Research Square from January 1, 2020, May 31, 2020. We used custom-designed program obtain...
To determine whether increased calcium intake (2 g/day) in pregnancy is effective reducing the risk of preeclampsia pregnant teenagers.The present study was a prospective, randomized, double-blind, controlled clinical trial. Two hundred sixty teenaged girls attending Hospital Gíneco-Obstétrico Isidro Ayora Quito, Ecuador, were included. Selection criteria age less than 17.5 years, nulliparity, first prenatal visit before 20 weeks' gestation, and residency Quito (2800-m altitude). We used...
Context:Ecuadorian subjects with GH receptor deficiency (GHRD) have not developed diabetes, despite obesity.
Rapid development in low- and middle-income countries (LMIC) has led to changes diet that have outpaced water sanitation improvements, contributing a dual burden of overweight noncommunicable disease risk factors (OWT/NCD) undernutrition infectious symptoms (UND/ID) within individuals households. Yet, little work examined the joint impact food exposures on burden.
We present the distribution of CYP 2D6 , 2C9 and 2C19 variants predicted phenotypes in 33 native admixed populations from Ibero‐America ( n > 6,000) context genetic ancestry = 3,387). Continental ancestries are major determinants frequencies increased‐activity allele 2C19*17 gUM s (negatively associated with Native American ancestry), decreased‐activity alleles 2D6*41 2C9*2 (positively European 2D6*17 2D6*29 African ancestry). For rare alleles, CYPC 19*17 admixture accounts for their...
Growth hormone receptor deficiency (GHRD) results in short stature, enhanced insulin sensitivity, and low circulating levels of insulin-like growth factor 1 (IGF-1). Previous studies mice humans suggested that GHRD has protective effects against age-related diseases, including cancer diabetes. Whereas show improved age-dependent cognitive performance, the effect on human cognition remains unknown. Using MRI, we compared brain structure, function, connectivity between 13 people with 12...
Pharmacogenetic variation in Latin Americans is understudied, which sets a barrier for the goal of global precision medicine. The RIBEF-CEIBA Network Consortium was established to characterize interindividual and between population variations CYP2D6, CYP2C9, CYP2C19 drug metabolizing enzyme genotypes, were subsequently utilized catalog their "predicted metabolism phenotypes" across Native American Ibero populations. Importantly, we report this study, total 6060 healthy individuals from...
To describe the sexual practices and behaviour towards HIV infection among Ecuadorian university students. This was a cross-sectional, descriptive study carried out between February 2019 August 2020 students from all over country. Students aged 18 years older of each participating institution were contacted by an official email account invited to fill survey through Google Forms. Data total 5677 sexually active participants analysed. The majority female (57.1%), 48.7% corresponded age range...
Background The COVID-19 pandemic has widened inequities, affecting migrant and refugee populations in vulnerable situations, who may face elevated risks of infection, constrained healthcare access discrimination. Inclusive vaccination campaigns are recommended, but barriers persist. This study aimed to identify facilitators estimate coverage among refugees migrants low- middle-income countries, emphasising inclusive policies for effective rollout. Methods A mixed-method was conducted two...
Genetic variations within the cytochrome P450 (CYP450) superfamily of drug metabolizing enzymes confer substantial person-to-person and between-population differences in pharmacokinetics, by extension, highly variable clinical effects medicines. In this context, "personalized medicine," "precision "stratified medicine" are related concepts attributed to what is essentially targeted therapeutics companion diagnostics, aimed at improving safety effectiveness health interventions. We report...
Pharmacogenetics and Pharmacogenomics areas are currently emerging fields focused to manage pharmacotherapy that may prevent undertreatment while avoiding associated drug toxicity in patients. Large international differences the awareness use of pharmacogenomic testing presumed, but not well assessed date. In present study we review Latin American scientific community about perceived barriers for their clinical application. order that, have compiled information from 9 countries region using...