A5046535273- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Acute Kidney Injury Research
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Cardiac Arrhythmias and Treatments
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Mechanical Circulatory Support Devices
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Aortic aneurysm repair treatments
- Pain Management and Opioid Use
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac and Coronary Surgery Techniques
- Hemodynamic Monitoring and Therapy
- Immune Cell Function and Interaction
- Anesthesia and Pain Management
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Complement system in diseases
- Cardiac Fibrosis and Remodeling
Queensland Health
2024
Queensland University of Technology
2024
Royal Brisbane and Women's Hospital
2024
New Haven Unified School District
2024
The University of Texas Southwestern Medical Center
2014-2023
Center for Human Genetics
2009-2023
David Grant USAF Medical Center
2023
Southwestern Medical Center
2014-2022
Houston Methodist
2022
Methodist Hospital
2022
Atrial fibrillation (AF) is the most common adverse event following coronary artery bypass graft surgery. A recent study identified chromosome 4q25 variants associated with AF in ambulatory populations. However, their role postoperative unknown. We hypothesized that genetic chromosomal region are independently after surgery.Two prospectively collected cohorts of patients undergoing surgery, or without concurrent valve at 3 US centers. From a discovery cohort 959 patients, clinical and...
Acute kidney injury (AKI) after coronary artery bypass graft (CABG) surgery is associated with increased postoperative morbidity and mortality. We hypothesized that plasma neutrophil gelatinase-associated lipocalin (NGAL) measured immediately separating from cardiopulmonary (CPB) would predict AKI CABG surgery.In a retrospective observational study, we examined the value of NGAL CPB for predicting risk developing (defined as > or = 50% increase in serum creatinine preoperative levels) 879...
Background— Postoperative atrial fibrillation (PoAF) is common after coronary artery bypass grafting. We previously showed that susceptibility single nucleotide polymorphisms (SNPs) at the chromosome 4q25 locus are associated with PoAF. Here, we tested hypothesis a combined clinical and genetic model incorporating risk SNPs would be superior to clinical-only model. Methods Results— developed externally validated clinical/genetic models for The discovery validation cohorts included 556 1164...
Summary Statement Psychological stress arises from a stressor placed on an individual that leads to both emotional and physiological responses. The latter is referred as psychophysiological stress. Healthcare simulation provides platform investigate psychobiology its effects learning performance. However, measures may be underused in healthcare research. inclusion of such with subjective research more complete picture the response, thereby furthering understanding impact goals this article...
AimsCardiac biomarkers are routinely elevated after uncomplicated cardiac surgery to levels considered diagnostic of myocardial infarction in ambulatory populations. We investigated the power electrocardiogram (ECG) and biomarker criteria predict clinically relevant injury using benchmarks mortality increased hospital length stay (HLOS) patients undergoing coronary artery bypass graft (CABG) surgery.
Heme oxygenase-1 (HO-1) catalyzes the degradation of heme, which may be involved in pathogenesis AKI. Length polymorphisms number GT dinucleotide repeats HO-1 gene ( HMOX1 ) promoter inversely associate with mRNA expression. We analyzed association between allelic frequencies and postoperative AKI 2377 white patients who underwent cardiac surgery cardiopulmonary bypass. categorized as having short allele (S; <27 repeats) or long (L; ≥27 repeats), defined an increase serum creatinine ≥0.3...
Acute kidney injury is a common and severe complication of critical illness cardiac surgery. Despite significant attempts at developing treatments, therapeutic advances to attenuate acute expedite recovery have largely failed.Identifying genetic loci associated with increased risk may reveal novel pathways for development.We conducted an exploratory genome-wide association study identify single-nucleotide polymorphisms susceptibility in-hospital injury.We genotyped 609,508 performed genotype...
Preoperative B-type natriuretic peptide (BNP) is known to predict adverse outcomes after cardiac surgery. The value of postoperative BNP for predicting less well delineated. authors hypothesized that peak plasma (measured days 1-5) predicts hospital length stay (HLOS) and mortality in patients undergoing primary coronary artery bypass grafting, even adjusting preoperative perioperative clinical risk factors.This study a prospective longitudinal 1,183 grafting Mortality was defined as...
Acute kidney injury (AKI) is an important complication of cardiac surgery. Recently, elevated levels endogenous ouabain (EO), adrenal stress hormone with haemodynamic and renal effects, have been associated worse outcome after Our aim was to develop evaluate a new risk model AKI using simple preoperative clinical parameters investigate the utility EO.The primary according Kidney Injury Network stage II or III. We selected Northern New England Cardiovascular Disease Study Group (NNECDSG) as...
Cardiac surgery-associated acute kidney injury (AKI) is associated with increased morbidity and mortality. We examined the utility of combining biomarkers function loss (serum cystatin C) tubular damage (urine neutrophil gelatinase-associated lipocalin [NGAL] Kidney Injury Molecule-1 [KIM-1]) for prediction post-cardiac surgery AKI.Single-center prospective cohort study 106 adults undergoing coronary artery bypass grafting and/or valve cardiopulmonary (CPB). Primary outcome was postoperative...
Ventricular dysfunction (VnD) after primary coronary artery bypass grafting is associated with increased hospital stay and mortality. Natriuretic peptides have compensatory vasodilatory, natriuretic, paracrine influences on myocardial failure ischemia. The authors hypothesized that natriuretic peptide system gene variants independently predict risk of VnD grafting.A total 1,164 patients undergoing cardiopulmonary at two institutions were prospectively enrolled. After defined exclusions, 697...
Heart-type fatty acid binding protein (hFABP) functions as a myocardial transporter and is released into the circulation early after injury. We hypothesized that hFABP superior to conventional cardiac biomarkers for predicting perioperative injury coronary artery bypass graft (CABG) surgery.A prospective cohort study of 1298 patients undergoing primary CABG with cardiopulmonary (CPB) was performed at 2 institutions. Four plasma (hFABP; troponin I [cTnI]; creatine kinase, MB [CK-MB] fraction;...
Background Preoperative C-reactive protein (CRP) levels more than 10 mg/l have been shown to be associated with increased morbidity and mortality after cardiac surgery. We examine the value of preoperative CRP less for predicting long-term, all-cause hospital length stay in surgical patients undergoing primary, nonemergent coronary artery bypass graft-only Methods examined association between stratified into four categories (< 1, 1-3, 3-10, > mg/l), 7-yr 914 prospectively enrolled...
Recent genome-wide association studies have identified several chromosome 9p21 single nucleotide polymorphisms associated with coronary artery disease and myocardial infarction in nonsurgical populations. We recently demonstrated an independent between these variants perioperative injury after isolated primary bypass graft (CABG) surgery. This study investigated the of a variant mortality patients CABG surgery its prognostic value to improve EuroSCORE.In 2-center, prospective, observational...
Abstract Background: Heart failure (HF) is a leading cause of hospitalization and mortality. Plasma B-type natriuretic peptide (BNP) an established diagnostic prognostic ambulatory HF biomarker. We hypothesized that increased perioperative BNP independently associates with or death up to 5 yr after coronary artery bypass graft surgery. Methods: The authors conducted two-institution, prospective, observational study 1,025 subjects (mean age = 64 ± 10 SD) undergoing isolated primary surgery...
The exact mechanisms that underlie the pathological processes of myocardial ischemia in humans are unclear. Cardiopulmonary bypass with cardioplegic arrest allows authors to examine whole transcriptional profile human left ventricular myocardium at baseline and after exposure cold cardioplegia-induced as a model.