A5022705706- Hemoglobinopathies and Related Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Iron Metabolism and Disorders
- Chronic Myeloid Leukemia Treatments
- Congenital Heart Disease Studies
- Airway Management and Intubation Techniques
- Chronic Lymphocytic Leukemia Research
- Pain Management and Opioid Use
- Pediatric Pain Management Techniques
- Intensive Care Unit Cognitive Disorders
- Eosinophilic Disorders and Syndromes
- Blood groups and transfusion
- Anesthesia and Sedative Agents
- Genomics and Rare Diseases
- Metabolism and Genetic Disorders
- Epigenetics and DNA Methylation
- Respiratory Support and Mechanisms
- Tracheal and airway disorders
- Cardiac Valve Diseases and Treatments
- RNA modifications and cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Mechanical Circulatory Support Devices
- Cardiac and Coronary Surgery Techniques
University of Asia Pacific
2024
Aga Khan University Hospital
2014-2024
Pasteur Institute of Iran
2013-2023
Biotechnology Research Center
2012-2023
National Institute of Genetic Engineering and Biotechnology
2009-2023
Institut Arnault Tzanck
2023
University of Sulaimani
2023
Ahvaz Jundishapur University of Medical Sciences
2018-2022
Islamic Azad University, Marvdasht
2022
Islamic Azad University, Jahrom Branch
2022
Rationale: Intensive care units (ICU) patients are highly vulnerable to inaccurate drug dosing. Pharmacogenomics (PGx) characterizes the influence of inherited genetic variation on metabolism, playing an important role in consequences a given dose. Objectives: To assess genetic-based risk dosing ICU. Methods: We carried out whole genome sequencing (WGS) 210 Qataris ICU at Hamad Medical Corporation (HMC), Doha, Qatar and assessed WGS for predicted deleterious variants genes that metabolize 30...
Background Preoperative anxiety is generally neglected in the evaluation of cardiac surgery patients due to various reasons including insufficient literature and lack simple assessment tools. In addition this, association between postoperative complications pain has been scarcely studied. The present study was designed assess preoperative levels all coming for then evaluate effect different on scores. Methods This prospective cohort conducted a single university hospital from March 2018...
Abstract Background Glutathione S‐transferases (GSTs) polymorphisms may impact on chronic myeloid leukemia (CML) risk or heterogeneous responses to Imatinib mesylate (IM). The aim of this study was evaluate the correlation between GSTs and CML risk, treatment response. Methods We genotyped GSTM1, GSTT1 null deletion polymorphisms, GSTP1 Ile105Val polymorphism by PCR methods BCR‐ABL transcripts were analyzed qRT‐PCR in 104 patients sex‐ age‐matched healthy individuals. Results Individual...
Early extubation after cardiac operations is an important aspect of fast-track anesthesia. In order to reduce or eliminate the adverse effects prolonged ventilation in pediatric congenital heart disease (CHD) surgical patients, concept early has been analyzed at our tertiary care hospital. The current study was carried out record data validate importance and safety (FTE) with evidence.A total 71 including male female aged 6 months 18 years belonging risk adjustment for surgery-1 category 1,...
Introduction: Mucopolysaccharidoses are a group of lysosomal storage disorders that include seven types classified based on the enzymes disrupted. Malfunction these leads to accumulation glycosaminoglycans (GAGs) in various tissues. Due genetic and clinical heterogeneity, diagnosing distinguishing different is challenging. Genetic methods such as whole exome sequencing (WES) Sanger accurate for detecting pathogenic variants patients. Methods: Thirty-two cases mucopolysaccharidosis,...
Abstract Background Cardiopulmonary bypass is associated with systemic inflammatory response. Steroids suppress this response, although the therapeutic evidence remains controversial. We hypothesised that intravenous steroids in children undergoing open-heart surgery would decrease inflammation leading to better early post-operative outcomes. conducted a randomised controlled trial evaluate trends levels of immunomodulators and their effects on clinical parameters. Objective To assess...
Alternative strategy of non-surgical closure patent ductus arteriosus (PDA) is presently the first line therapy. Several devices are being used for transcatheter PDA. A four-year-old girl underwent a second attempt at PDA with an amplatzer device. However, after deployment device it got dislodged into right pulmonary artery hilum. attempts by catheter retrieval failed. The surgical removal which was complicated injury and subsequent repair performed on cardiopulmonary bypass.
Abstract Background Transcriptome profiling in individuals affected with β‐thalassemia, especially who carry novel mutations the HBB, may improve our understanding of heterogeneity and molecular mechanisms disease. Methods Members a family daughter thalassemia intermedia, although her mother was not clinically affected, were examined. We also characterized genome‐wide gene expression using real‐time quantitative polymerase chain reaction high‐throughput RNA‐sequencing mRNA blood. Results...
Abstract MED27 is a subunit of the Mediator multiprotein complex, which involved in transcriptional regulation. Biallelic variants have recently been suggested to be responsible for an autosomal recessive neurodevelopmental disorder with spasticity, cataracts and cerebellar hypoplasia. We further delineate clinical phenotype MED27-related disease by characterizing radiological features 57 affected individuals from 30 unrelated families biallelic variants. Using exome sequencing extensive...