A5043690841- Nanoparticle-Based Drug Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA Interference and Gene Delivery
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Polyoxometalates: Synthesis and Applications
- Synthesis and Reactions of Organic Compounds
- Quinazolinone synthesis and applications
- Nanoplatforms for cancer theranostics
- Neonatal Respiratory Health Research
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Bioactive Compounds and Antitumor Agents
- Dendrimers and Hyperbranched Polymers
- Advanced Drug Delivery Systems
- Synthesis and Characterization of Heterocyclic Compounds
- Pulmonary Hypertension Research and Treatments
- Multicomponent Synthesis of Heterocycles
- Virus-based gene therapy research
- Fluorine in Organic Chemistry
- Computational Drug Discovery Methods
- 3D Printing in Biomedical Research
- biodegradable polymer synthesis and properties
- Advanced Polymer Synthesis and Characterization
- CRISPR and Genetic Engineering
Isfahan University of Medical Sciences
2016-2025
Cornell University
2019-2025
Weill Cornell Medicine
2020-2025
Islamic Azad University, Tehran
2025
University of Isfahan
2011-2023
Islamic Azad University, Mashhad
2023
Weatherford College
2022
Tufts University
2014-2015
Institute of Medicinal Plant Development
2014
University at Buffalo, State University of New York
2013
Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes disease (COVID-19), a predominantly illness. The first step in SARS-CoV-2 infection is binding of virus to
Stirred-suspension bioreactors are a promising modality for large-scale culture of 3D aggregates pluripotent stem cells and their progeny. Yet, within these clusters experience limitations in the transfer factors particularly O2 which is characterized by low solubility aqueous media. Cultured under different levels may exhibit significantly proliferation, viability differentiation potential. Here, transient diffusion-reaction model was built encompassing size distribution ultrastructural...
Folate and retinoic acid grafted/dextran (FA-RA/DEX) copolymers with different molecular weight of DEX were synthesized using carbonyldiimidazole dimethylaminopyridine for targeted delivery doxorubicin (DOX) in acute myelogenous leukemia (AML). The structure was confirmed by 1 H NMR FTIR. Critical micelle concentration (CMC) each copolymer determined pyrene as a fluorescent probe. DOX loaded micelles the direct dissolution method. Physical properties micelles, including particle size, zeta...
The aim of this study was to develop chitosan derivative polymeric micelles for co-delivery paclitaxel (PTX) and α-tocopherol succinate (α-TS) the cancer cells improve therapeutic efficiency reduce side effects PTX. In study, amphiphilic tocopheryl succinate-grafted oligosaccharide synthesized physically loaded by PTX α-TS with entrapment 67.9% 73.2%, respectively. Physical incorporation into increased hydrophobic interaction between core, which improved micelle stability, reduced size also...
Gefitinib as an epidermal growth factor receptor tyrosine kinase inhibitor has strong potential in lung cancer therapy. However, a major challenge of using gefitinib is its toxicities. In the present study, we developed dry powder inhaler dosage form containing loaded glucosamine targeted solid lipid nanopaticles (Gef-G-SLNs) to locally transfer anticancer agent tumor. The Gef-G-SLNs were prepared by emulsion-solvent diffusion and evaporation method optimized with irregular factorial design....
The objective of this study was the synthesis folic acid- (FA-) targeted polymeric micelles Synperonic PE/F 127-cholesteryl hemisuccinate (PF127-Chol) for specific delivery docetaxel (DTX). Targeted or nontargeted loaded with DTX were prepared via dialysis method. effects processing variables on physicochemical properties evaluated using a full factorial design. After optimization polymer/drug ratio, organic solvent type used preparation micelles, and temperature dialyzing medium, in vitro...
Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic fibrotic lung disease with an irreversible decline of function. "Bronchiolization", characterized by ectopic appearance airway epithelial cells in the alveolar regions, one characteristic features IPF lung. Based on knowledge that club are major secretory human small airways, and their product uteroglobin (SCGB1A1) significantly increased both serum lining fluid lung, we hypothesize contribute to pathogenesis IPF. By assessing...
CLN2 disease (late infantile neuronal ceroid lipofuscinosis) is an autosomal recessive, neurodegenerative lysosomal storage that results from loss of function mutations in the gene, which encodes tripeptidyl peptidase 1. It affects central nervous system (CNS) with progressive neurodegeneration and early death, typically at ages 8 to 12 years. Twenty years ago, our phase I clinical trial treated subjects by a catheter-based CNS administration adeno-associated virus vector serotype 2 (AAV2)...
Rationale: Intensive care units (ICU) patients are highly vulnerable to inaccurate drug dosing. Pharmacogenomics (PGx) characterizes the influence of inherited genetic variation on metabolism, playing an important role in consequences a given dose. Objectives: To assess genetic-based risk dosing ICU. Methods: We carried out whole genome sequencing (WGS) 210 Qataris ICU at Hamad Medical Corporation (HMC), Doha, Qatar and assessed WGS for predicted deleterious variants genes that metabolize 30...
Employing polycations as non-viral gene delivery vectors has been extensively studied owing to their safety, efficiency and possibility of modifying them in an intended way compared with viral vectors. However, the main challenge is finding a biocompatible transfection-efficient polymer. In this study, 2-aminoethyl methacrylate (A) 1-vinyl imidazole (V) were copolymerized at three different molar ratios by free radical polymerization method novel narrow molecular weight distribution...
A water-insoluble anti-tumor agent, paclitaxel (PTX) was successfully incorporated into novel-targeted polymeric micelles based on tocopherol succinate-chitosan-polyethylene glycol-folic acid (PTX/TS-CS-PEG-FA). The aim of the present study to evaluate pharmacokinetics, tissue distribution and efficacy PTX/TS-CS-PEG-FA in comparison Anzatax® tumor bearing mice. micellar formulation showed higher vitro cytotoxicity against mice breast cancer cell line, 4T1, due folate receptor-mediated...
Airway remodelling in chronic obstructive pulmonary disease (COPD) originates, part, from smoking-induced changes airway basal stem/progenitor cells (BCs). Based on the knowledge that bone morphogenetic protein 4 (BMP4) influences epithelial progenitor function developing and adult mouse lung, we hypothesised BMP4 signalling may regulate biology of human BCs relevant to COPD. components epithelium were analysed at mRNA levels, differentiation was assessed using BC expansion air–liquid...
The human small airway epithelium (SAE) plays a central role in the early events pathogenesis of most inherited and acquired lung disorders. Little is known about molecular phenotypes specific cell populations comprising SAE humans, contribution to risk for diseases.Drop-seq single-cell RNA-sequencing was used characterize transcriptome single cells from nonsmokers smokers by bronchoscopic brushing.Eleven distinct were identified, including major rare epithelial cells, immune/inflammatory...
PPF–MPEG/Fs/Hst–GNPs caused significant enhancement in mineralization, differentiation, cell proliferation and higher expression of bone-specific genes including; collagen 1, osteocalcin, osteopontin compared to the blank hydrogel.
A series of novel 4-anilinoquinazoline derivatives were designed and synthesized from benzoic acid through ring closure, chlorination or nucleophilic substitution. The structures compounds characterized by IR, 1H-NMR mass spectroscopy. All screened for their antimicrobial activities against Gram-positive (Staphylococcus aurous, Bacillus subtilis, Listeria monocitogenes) Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Salmonella entritidis) bacteria also antifungal Candida albicans...
To develop an effective therapeutic treatment, the potential of poly (lactic-co-glycolic acid)-polyethylene glycol-retinoic acid (PLGA-PEG-RA) polymeric micelles for targeted delivery irinotecan to hepatocellular carcinoma (HepG2) and colorectal cancer cell lines (HT-29) was evaluated. PLGA-PEG-RA synthesized by amide reaction PLGA with NH2–PEG–NH2 then PLGA-PEG-NH2 RA confirmed FTIR 1H NMR spectroscopy. Irinotecan-loaded nanomicelles were prepared using thin-film hydration method impact...