A5052118518- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Inflammatory Bowel Disease
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- IL-33, ST2, and ILC Pathways
- Blood disorders and treatments
- Marine and environmental studies
- Epigenetics and DNA Methylation
- Marine Invertebrate Physiology and Ecology
- T-cell and B-cell Immunology
- Microscopic Colitis
- DNA Repair Mechanisms
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Cancer-related gene regulation
- Diabetes and associated disorders
- Advanced Glycation End Products research
- RNA modifications and cancer
- Carcinogens and Genotoxicity Assessment
- Immune responses and vaccinations
- Erythrocyte Function and Pathophysiology
- Mycobacterium research and diagnosis
- Chronic Myeloid Leukemia Treatments
- Mitochondrial Function and Pathology
Children's Medical Center
2012-2025
Tehran University of Medical Sciences
2014-2025
Ludwig-Maximilians-Universität München
2020-2023
Shariati Hospital
2017-2023
Universal Scientific Education and Research Network
2017-2022
University of Tehran
2012-2020
Iranian National Institute for Oceanography and Atmospheric Science
2012-2013
Ahvaz Jundishapur University of Medical Sciences
2013
Hôpital Broca
2009
Assistance Publique – Hôpitaux de Paris
2009
HEM1 deficiency causes heritable autoimmunity and immunodeficiency.
Dinoflagellate cyst assemblages were analysed in four short sediment cores collected the south Basin of Caspian Sea for assessing environmental changes over last few millennia. Two these dated by radionuclides. The sedimentation rate one them was very high, order 20 mm per year. interpretation sequences is supported a collection 27 lagoonal or marine surface samples. A sharp increase concentration dinocyst occurs after 1967, especially owing to Lingulodinium machaerophorum. Considering nine...
Objectives: Ataxia-telangiectasia (A-T) is an autosomal recessive neurodegenerative disorder with multisystem involvement caused by homozygous or compound heterozygous mutations in the ataxia telangiectasia mutated (ATM) gene which encodes a serine/threonine protein kinase. The aims of this study were to investigate class switch recombination (CSR) and review clinical immunologic phenotypes 3 groups A-T patients, including patients CSR defects (CSR-D), selective immunoglobulin A deficiency...
Abstract Background Ataxia telangiectasia mutated (ATM) kinase plays a critical role in DNA double-strand break (DSB) repair. (A-T) patients exhibit abnormalities immunoglobulin isotype expression and class switch recombination (CSR). This study investigates the of residual ATM activity severity A-T disease. Methods with defined genetic diagnoses were classified based on CSR their medical complications. Isolated peripheral blood mononuclear cells from any patient evaluated before after...
Griscelli syndrome type II is a primary immunodeficiency disorder caused by RAB27A gene mutation. It inherited in an autosomal recessive manner and characterized oculocutaneous hypopigmentation various cellular immune system deficiencies. Herein, we report 5-year-old girl with silvery-gray hair, eyebrows, eyelashes who was referred to our deficiency clinic because of recurrent oral thrush. Further investigations were performed uncover the probable underlying genetic disorder. Whole-exome...
Background: Inflammatory bowel disease (IBD) is a chronic relapsing-remitting inflammatory of the intestinal tract. Tumor necrosis factor-alpha (TNF-α) signaling plays major role in pathogenesis IBD and commonly targeted for therapeutic purposes. Results on contribution TNF-α -308 -238 single nucleotide polymorphisms (SNP) to susceptibility have been contradictory differ- ent populations. Methods: Allele frequency genotype status SNPs were investigated 75 un- related patients with [40...
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and leading cause of childhood death in contrast to 90% cure rate. ALL includes different subtypes described by interrupt collections somatic chromosomal alterations sequence mutations that disrupt normal body functions such as lymphoid maturation, cell-cycle regulation, tumor suppression. Having a significant role several cancers, high mobility group box-1 (HMGB1) gene considered an important development tumors....
WHIM syndrome ( Warts, Hypogammaglobulinemia, Immunodeficiency, and Myelokathexis syndrome), a type of severe congenital neutropenia (SCN), involves Infections, as its main components clinical presentation, which results from mutations in the C-X-C chemokine receptor 4 (CXCR4) gene. Here, we present an Iranian 4-year-old girl with without warts normal bone marrow examination, lacking evidence myelokathexis. Whole Exome Sequencing (WES) was performed for patient. Subsequently, Sanger...
Changes in cytokine expression have been frequently found patients with inflammatory bowel disease (IBD). Cytokine values outside the normal range may be somewhat related to common polymorphisms within genes.The present study was designed investigate possible association between Interleukin IL-4 and IL-10 genes susceptibility clinical features of IBD.The population composed 140 healthy controls 75 IBD (40 Crohn's (CD) 35 ulcerative colitis (UC)). Genotyping performed using polymerase chain...
The south Caspian subbasin extends from the foot of Alborz Mountains to deepest part Sea. lithological background and tectonic setting study area primarily control deposition thick sedimentary sequences basin, while hydroclimatic processes exert secondary impacts on sediment distribution pattern. To evaluate past changes, short cores were retrieved continental shelf upper slope Sea treated for basic sedimentological properties mineralogy. results show that sediments are composed terrigenous,...
Background: Common variable immunodeficiency (CVID) is one of the most prevalent forms primary diseases (PID). CVID characterized by failure in final differentiation B lymphocytes and impaired antibody production but pathogenesis not known majority patients. We postulated that expression pattern miRNAs unsolved patients might be underlying epigenetic cause disease. Therefore, we aimed to assess hsa-miR-210-5p FOXP3 transcription factor cases comparison with healthy individuals. Methods:...
Objectives: Common variable immunodeficiency is a primary disease characterized by hypogammaglobulinemia and heterogeneous clinical features. Neutropenia rare complication among CVID patients leading to higher rate of infections morbidity. Multiple factors (e.g. autoimmunity, infections, drugs etc.) are found underlie this complication.Methods: In the present study, demographic, laboratory data were compared between two groups with without neutropenia.Results: Frequency neutropenia was 8.1%....
Common variable immunodeficiency (CVID) is a primary disease with heterogeneous genetic background. Lipopolysaccharide-responsive beige-like anchor (LRBA), as well cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), have important regulatory roles in the immune responses. Here, we investigated expression of LRBA and CTLA-4 proteins CVID patients at least one presentation early-onset occurrence, autoimmunity, or enteropathy. In this study, 20 newly diagnosed without infection only...
Background. Primary ciliary dyskinesia (PCD), also known as the immotile-cilia syndrome, is a clinically and genetically heterogeneous syndrome. Improper function of cilia causes impaired mucociliary clearance. Neonatal respiratory distress, rhinosinusitis, recurrent chest infections, wet cough, otitis media are presentations this disease. It could manifest infertility in males well laterality defects both sexes, such situs abnormalities (Kartagener syndrome). During past decade, numerous...