A5101956647- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Genetic Neurodegenerative Diseases
- RNA regulation and disease
- Essential Oils and Antimicrobial Activity
- Genomics and Rare Diseases
- melanin and skin pigmentation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Phytochemistry and Biological Activities
- Hearing, Cochlea, Tinnitus, Genetics
- Sexual Differentiation and Disorders
- Cancer Genomics and Diagnostics
- Immunodeficiency and Autoimmune Disorders
- Genetics and Neurodevelopmental Disorders
- Cancer-related Molecular Pathways
- Biochemical Analysis and Sensing Techniques
- Neurological disorders and treatments
- Hedgehog Signaling Pathway Studies
- Cardiac electrophysiology and arrhythmias
- Folate and B Vitamins Research
- Connexins and lens biology
- Neuroscience of respiration and sleep
- Hormonal and reproductive studies
- Retinoids in leukemia and cellular processes
- BRCA gene mutations in cancer
Tarbiat Modares University
2012-2021
Islamic Azad University, Tehran
2009
Essence Line (Czechia)
2007
To determine the prevalence and geographic distribution of thalassemia to evaluate success prevention treatment programs in Iran.Data were obtained from National Thalassemia Registry Iran, Iranian Blood Transfusion Organization, genetic laboratories involved prenatal diagnosis, related pharmaceutical companies, centers performing bone marrow transplantation for thalassemic patients.A total 13,879 living patients have been registered, mostly northern southern parts Iran with median age 15...
Abstract The essential oil obtained by hydrodistillation of the stems and leaves Xanthium strumarium L. aerial parts Centaurea solstitialis (two Compositae species Iran) were analyzed GC GC/MS. Twenty-two compounds representing 86.4% stem identified, among which bornyl acetate (19.5%), limonene (15.0%) β-selinene (10.1%) major ones. leaf plant was characterized higher amount (24.7%) borneol (10.6%) 28 components comprising 85.2% total detected. Eighteen identified in 86.6% with hexadecanoic...
We studied 325 thalassemia intermedia patients from Iran, India, Pakistan, Thailand, Mauritius and Cyprus to examine factors which influence the phenotype. The β-thalassemia (thal) mutations were determined for 219 β-thal/β-thal 106 β-thal/Hb E [β26(B8)Glu→Lys, GAG→AAG] patients. Thirty-one different identified, their combination gave rise more than 44 genotypes, of 14 (31.8%) had β0/β0, 21 (47.7%) β0/β+ nine (20.5%) β+/β+ types. Thus, β+-thal present in 68.2% patients.α-Thalassemia...
Background: Defects in the CYP21A2 gene cause steroid 21-hydroxylase deficiency, which is most frequent of congenital adrenal hyperplasia. Forty four affected families were investigated to identify mutation spectrum gene. Methods: Families subjected clinical, biochemical, and molecular analyses. Allele-specific polymerase chain reaction amplification was used for eight common mutations followed by dosage analysis exclude deletions. Results: The detected deletions chimera (31.8%). Other...
Thalassemia intermedia shows considerable heterogenity in phenotype and molecular basis. The aim of this study was to evaluate the prevalence effect different beta-globin mutations, alpha-globin defects (G)gamma XmnI polymorphisms Iranian patients. Forty-five patients with clinical criteria thalassemia were studied. background diseases investigated. mean age onset varied from 1.5 30 years. Only 22.2% cases received occasional blood transfusions. hemoglobin (Hb) level more than half stable...
Background/aims SLC4A11 is the only known causative gene of congenital hereditary endothelial dystrophy (CHED). Mutation screenings have shown that most but not all patients with CHED harbour mutations in , suggesting other CHED-causing genes may exist. We aimed to screen Iranian learn mutation spectrum this among Iranians and gain further knowledge on potential contribution aetiology. Methods was screened 21 by sequencing. Previously unreported variations were checked at least 200 controls,...
Abstract Water-distilled essential oils from the aerial parts of Artemisia turanica Krasch., Helichrysum oocephalum Boiss. and flower Centaurea ispahanica which latter two are endemic to Iran, were analyzed by GC GC-MS. Nineteen components oil A. characterized, representing 90.6% total detected. The major constituents identified as 1.8-cineole (23.3%), chrysanthenone (21.3%) davanone (19.3%). H. was characterized higher amount β-caryophyllene (13.5%), menthone (10.8%), dodecane (9.1%)...
Background . Beta thalassemia is one of the most common hereditary disorders worldwide. In Iran, it frequently reported from northern and southern provinces. order to prevent child birth be affected by this complication, prenatal screening diagnosis are carried out nationwide. However, in some instances, program unable identify rare mutations leading thalassemia. Case Presentation A married couple, who took part diagnosis, gave a major. After several molecular examinations, mutation [+22...
Background: Folate and methionine metabolism enzymes could affect DNA synthesis repair, their methylation polymorphisms have been associated with some forms of cancer. This study was carried out to investigate whether the MTHFR C677T (rs1801133), A1298C (rs1801131) TYMS 2R/3R (rs34743033) are susceptibility retinoblastoma in an Iranian population.Methods: A case-control conducted involving 96 patients 204 healthy controls. Genotyping C677T, A1298C, polymorphism were assessed by PCR-RFLP,...
Mohammad Hamidab, Frouzandeh Mahjoubia, T. Akbaric, Aida Arabb, Sirous Zeinalib & Morteza Karimipoor*ba Department of Clinical Genetics, National Institute Genetic Engineering and Biotechnology (NIGEB), Tehran, Iranb Molecular Medicine, Research Centre, Pasteur Iran, Iranc Medical Faculty Sciences, Tarbiat Modares University, Iran
Prostate cancer is the second form of among men worldwide. For early detection, we should identify tumors in initial stages before physical signs become visible. The present study aims to evaluate diagnostic value cell-free DNA (cfDNA), its comparison with prostate-specific antigen (PSA) level prostate screening and also patients localized cancer, metastatic form, benign prostatic hyperplasia (BPH).The participants this were selected from 126 genitourinary symptoms suspected rising PSA,...
Abstract Water-distilled essential oils from the aerial parts of three Stachys species: S. asterocalyx Rech. f., obtusicrena Boiss., which are endemic to Iran, and multicaulis Benth. were analyzed by GC GC/MS. The major components oil α-bisabolol (25.1%) linalool (18.0%). In obtusicrena, α-pinene (34.6%), germacrene D (8.0%) bicyclogermacrene (7.8%) found be constituents. Bicyclogermacrene (23.0%), spathulenol (20.7%), (12.4%) caryophyllene oxide (11.1%) predominant compounds in multicaulis.
Metastasis might be latent or occur several years after primary tumor removal. Currently used methods for detection of distant metastasis have still some limitations. Blood tests may improve sensitivity and specificity currently screening procedures. The present study was designed to investigate promoter methylation status DAPK1 CAVIN3 genes in plasma circulating free DNA (cfDNA) samples Iranian invasive ductal carcinoma (IDC) patients. We also investigated association two gene methylations...