Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PPARGC1A) regulates the expression of energy metabolism’s genes and mitochondrial biogenesis. The essential roles PPARGC1A encouraged researchers to assess relation between metabolism-related diseases its variants. To study Gly482Ser (+1564G/A) single-nucleotide polymorphism (SNP) after modeling, we substitute Gly482 for Ser482. Stability prediction tools showed that this substitution decreases stability or has a...

This study was conducted on 87 patients with chronic periodontitis (CP), 50 peri-implantitis and 90 periodontally healthy individuals referring to the Department of Periodontics for evaluating association between Fc gamma-receptor genes polymorphisms CP peri-implantitis. After obtaining consent, venous blood samples (5cc) were obtained from DNA extracted using Miller's salting-out method. Polymerase chain reaction (PCR)-restriction fragment length polymorphism tetra-primer amplification...

Background: Retinoblastoma is a rare malignant intraocular neoplasm. About 90% of cases feature germline mutation in the RB1 gene and these will develop retinoblastoma during their early childhood. An association between mutations cells aging has been demonstrated. This suggests higher incidence childhood cancer including among children older parents. Materials Methods: In present study we aimed to determine paternal maternal age with an increased risk case-control Iranian population. The...

ABSTRACT Objectives Peri‐implantitis (PI) is the most common biological issue surrounding dental implants. According to current knowledge, aforementioned complication not equally distributed across different populations, and gene polymorphisms might be one contributing factor. The study aimed examine association between of matrix metalloproteinase‐ (MMP‐) 1, ‐2, ‐3, ‐7, ‐13 with PI in an Iranian demographic. Material Methods study's sample included 50 subjects suffering from 89 healthy...

The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. Several studies have demonstrated a significant association between Pro12Ala polymorphism of PPAR-γ2 gene and metabolic disorders. Therefore, this study aimed evaluate with increased risk NAFLD in Iranian patients type 2 diabetes mellitus.This cross-sectional was performed on 145 healthy control subjects history diabetes. genotyping using...

To determine whether the HFE gene variants H63D and C282Y are associated with NAFLD in persons type 2 diabetes, we conducted a case-control study including 145 case of patients history diabetes matching control. The genomic DNA was extracted from peripheral venous blood genotyping mutations analyzed using PCR-RFLP technique. Statistical analysis performed SPSS 12.0 software by χ2 test, t test ANOVA (P<0.05). Data showed no increased frequency association between mutation population. Also,...

Environmental and genetic factors may play a major role in the development of nonalcoholic fatty liver disease (NAFLD) among people with obesity type 2 diabetes mellitus. Based on fact that PGC-1α, as protein encoded by PPARGC1A gene, plays key energy metabolism pathways, it has been hypothesized polymorphisms within PPARGC1Agene be associated increased risks NAFLD. Thus, this study was designed to evaluate Gly482Ser polymorphism (rs8192678) gene its association risk NAFLD Iranian patients...

Abstract Background Chronic periodontitis (CP) is a prevalent infectious disease caused by an interplay between pathogens and immune responses. Gene polymorphisms are among the factors that affect susceptibility to CP. This study aimed assess association CP single nucleotide (SNPs) of interleukin-10 (IL-10), interleukin 1 ß (IL-1 ), tumor necrosis factor- α (TNF- ) genes. Methods A total 87 patients with 89 healthy controls were included in this study. Venous blood samples obtained, DNA was...

Diabetes mellitus is a risk factor for cardiovascular diseases (CVDs), which are among the major causes of deaths in type 2 diabetes (T2D). The purpose present study was to determine association C282Y and H63D mutations HFE gene with increased coronary artery disease (CAD) T2D patients.Two hundred ninety individuals were divided into two groups: case group control group. Genomic DNA peripheral venous blood cells extracted analyzed using PCR-RFLP technique.Data analysis revealed significant...

Background. Peroxisome proliferator-activated receptor-γ (PPARγ) gene is located at 3p25 position. PPARγ functions as the master regulator of glucose homeostasis and lipoprotein metabolism, recent studies have reported that it involved in various metabolic diseases such diabetes mellitus, hyperlipidemia, coronary artery disease (CAD), nonalcoholic fatty liver (NAFLD). PPARγ1 PPARγ2 are necessary for development adipose tissue insulin sensitivity regulation. But isoform was controlled...

Coronary artery disease (CAD) is one of the common diseases in patients with type two diabetes mellitus (T2DM). The nuclear hormone receptor peroxisome proliferator-activated receptor-gamma (PPARγ) plays a vital role dyslipidemia, and oxidative stress involved atherogenesis.The study aimed to determine association between Pro12Ala polymorphism PPARγ2 gene(rs1801282) CAD risk T2DM Iranian population.A group 145 history were enrolled, together sex gender-matched individuals who had neither nor...

The Prevalence of VIM, IMP, and NDM-1 Metallo-beta-Lactamase Genes in Clinical Isolates Klebsiella pneumoniae Qom Province, Iran

Background: Lung cancer is the most common with 2,206,771 new cases in 2020 worldwide. MMP9 a member of matrix metalloproteinase family that also known as gelatinase B or IV type collagenase (92KD). through degrading Extracellular Matrix (ECM) and releasing growth factors has fundamental role tumorigenesis process. The C -1562 T SNP promoter increases expression susceptibility to lung cancer. Then, aim this present case-control study was investigate whether genetic variations gene may...

Purpose: CYP3A4 (cytochrome P450, family 3, subfamily A, polypeptide 4) is an important enzyme in the body. The purpose of this to oxidize small foreign organic molecules such as drugs or toxins. different genetic variants present individuals CYP3A4*4. cytochrome P450 3A have role catabolic reactions like many peroxidative, oxadative, and reductive biotransformation common Carbamazepine, Hydroxylations Nevirapine.Methods: In study, prevalence CYP3A4*4 healthy subject Iran were analyzed....

Abstract Background . Type 2 diabetes (T2DM) is a risk factor for coronary artery disease (CAD) in patients with type compared subjects without diabetes. Many studies have been shown that CAD has resulted from the interaction of genetic markers implicated dyslipidaemia and oxidative stress. The PPARγ gene considered as potential candidate link between mellitus mellitus. purpose present study was to determine association Pro12Ala PPARγ2 polymorphism (rs1801282) Iranian T2DM. Methods. We...

Background: Carbapenem-resistant Klebsiella pneumonia (K. pneumoniae) has been recently identified as the major class of pathogens and treatment became biggest challenge in this bacterium. We assessed antibiotic resistance patterns K. pneumoniae, frequency resistant strains to imipenem, meropenem, ertapenem, pneumoniae carbapenemases (KPC), Guiana-Extended-Spectrum (GES) metallo-β-lactamase genes. Methods: The phenotypes 200 pneumonia, collected from 650 clinical samples, were isolating Qom,...

Background: Behçet's disease (BD) is a chronic inflammatory with unknown causes. The geographical distribution mostly consistent the historic Silk Road. role of tumor necrosis factor receptor-associated 5 (TRAF5) gene in inflammation signaling pathway leads more attention to potency different polymorphisms TRAF5 gene, development BD. Methods: This was case-control study conducted among Azeri Turk ethnic group (50 BD patients and 50 persons no history autoimmune disease), Tabriz, Iran. Four...