A5074659472- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Cancer Risks and Factors
- Endometriosis Research and Treatment
- DNA Repair Mechanisms
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Obesity, Physical Activity, Diet
- COVID-19 Clinical Research Studies
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Birth, Development, and Health
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Fatty Acid Research and Health
- PARP inhibition in cancer therapy
- Endometrial and Cervical Cancer Treatments
- Reproductive System and Pregnancy
- Effects of Radiation Exposure
- Estrogen and related hormone effects
- Immune Cell Function and Interaction
- Radiation Therapy and Dosimetry
- Advanced biosensing and bioanalysis techniques
Tehran University of Medical Sciences
2015-2024
Tarbiat Modares University
2011-2012
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been responsible for the recent pandemic since early 2020. Due to wide range of clinical symptoms this disease, from asymptomatic severe and critical forms, it seems that genetic differences among patients, along with other factors (such as gender, age, underlying diseases), can explain part variation in disease symptoms. The TMPRSS2 enzyme plays a vital role stages interaction SARS-CoV-2 host cells by facilitating viral entry....
Abstract COVID-19 has caused the recent pandemic of respiratory infection, which threatened global health. The severity symptoms varies among affected individuals, from asymptotic or mild signs to severe critical illness. Genetic predisposition explains variation in disease patients who suffer without any known background risk factors. present study was performed show association between APOE genotype and disease. 201 (101 with asymptomatic form as control group 100 illness factors case...
This study is the first to identify effects of FTO genotype on interactions between level macro-nutrients intake and expression fat mass obesity associated (FTO) homeobox transcription factor iriquois-3 (IRX3) genes longitudinal was carried out 84 overweight obese adolescent boys in Tehran, Iran. The rs9930506 SNP genotyped at baseline IRX3 PBMCs macro-nutrients' were assessed after 18 weeks intervention. results identified that higher carbohydrates significantly up-regulated gene (P =...
Approximately 70% of all cancer patients receive radiotherapy. Although radiotherapy is effective in killing cells, it has adverse effects on normal cells as well. Melatonin (MLT) a potent antioxidant and anti-inflammatory agent been proposed to stimulate DNA repair capacity. We investigated the capability MLT modification radiation-induced damage rat peripheral blood cells.In this experimental study, male rats (n = 162) were divided into 27 groups 6 each group) including: irradiation only,...
Abstract Background Lifestyle intervention may have a critical effect on the association between genetics and obesity. This study aimed to investigate changes in FTO IRX3 gene expression obese overweight male adolescents undergoing lifestyle role of genotype this interaction. Methods was field trial 62 from boys’ high schools Tehran, Iran. Two were randomly allocated as (n = 30) control 32) schools. The rs9930506 SNP genotyped at baseline level peripheral blood mononuclear cells (PBMCs)....
Single-nucleotide polymorphisms (SNPs), which are located in the first intron of FTO gene, reported to be associated with body weight and mass index (BMI). However, their effects on anthropometric measurements adolescents poorly understood.This study aimed investigate association three adjacent (rs9930506, rs9930501, & rs9932754) gene indices Iranian adolescent males.The participants comprised a total 237 males who were recruited randomly from two high schools Tehran, Iran. The DNA samples...
The modifying effect of FTO gene expression level on change in body mass index and composition has not been studied before. This study aimed to investigate the association between changes anthropometric measurements obese overweight adolescent boys.Eighty-four boys aged 12 16 years participated this longitudinal study. A Bio Impedance Analyzer (BIA) was used estimate percentage fat (%BF) skeletal muscle (%SM). peripheral blood mononuclear cells assessed using quantitative real-time PCR...
Long noncoding RNAs (lncRNAs) constitute a major class of the human transcriptome which play crucial roles in key biological processes both normal and malignant breast cells. Although aberrant expression lncRNAs has been well-documented cancer (BC), little is currently known about association between their levels tissue healthy women BC risk factors, especially reproductive or demographic characteristics that are among most well-known modifiers. This study was an attempt to investigate...
Poly (ADP-ribose) polymerase-1 (PARP-1) plays an important role in the repair of damaged DNA and has prognostic significance a variety human malignancies. However, little is known about its expression levels clinical implication patients with acute myeloid leukemia (AML).Quantitative reverse transcription-polymerase chain reaction was done to evaluate PARP-1 bone marrow 65 non-M3 AML 54 healthy counterparts. The correlation clinicopathological features also analyzed.Non-M3 have higher than...
Abstract Obesity is associated with breast cancer aggressiveness and drug resistance. Although the underlying mechanisms are unknown, recent studies indicated that exosomes have a principal contributory role in obesity‐associated metabolic complications. Hence, we investigated whether obesity can mediate progression resistance to tamoxifen by plasma‐derived‐exosomes from obese women or not. Plasma isolated five normal‐weight (N‐Exo) (O‐Exo) were characterized for size, zeta potential, CD63...
Thalassemia intermedia shows considerable heterogenity in phenotype and molecular basis. The aim of this study was to evaluate the prevalence effect different beta-globin mutations, alpha-globin defects (G)gamma XmnI polymorphisms Iranian patients. Forty-five patients with clinical criteria thalassemia were studied. background diseases investigated. mean age onset varied from 1.5 30 years. Only 22.2% cases received occasional blood transfusions. hemoglobin (Hb) level more than half stable...
Background: Reproductive history and obesity are among the well-recognized risk factors in development of breast cancer, which partially mediated by increased exposure tissues to estrogens. However, only a few studies have investigated link between these pattern methylation signatures tissue healthy women. The role estrogen receptor 1 (ESR1) gene hypermethylation is reportedly important cancer. Thus, it speculated that such ESR1 epigenetic changes may be influenced or shaped reproductive...
Critical roles of epigenomic alterations in the pathogenesis breast cancer have recently seized great attentions toward finding epimarkers either non-invasive or semi-non-invasive samples as well peripheral blood. In this way, methylated DNA immunoprecipitation microarray (MeDIP-chip) was performed on isolated from white blood cells 30 patients compared to healthy controls. A total 1799 differentially regions were identified including SLC6A3, Rab40C, ZNF584, and FOXD3 whose significant...
Maternal high-fat diet has been shown to have deleterious effects on the offspring bones. However, there is no study assess of type and amount maternal dietary oil in an isocaloric diet, with focus extra virgin olive (EVOO). The objective current was test hypothesis that more than its during gestation lactation bone genes expression adolescence.Virgin female C57BL/6 mice were impregnated fed either AIN 93G (received 16% calories as soybean oil, a control or EVOO) high fat 45% from time...