A5088213536- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Parkinson's Disease Mechanisms and Treatments
- Neural dynamics and brain function
- Pancreatic function and diabetes
- Nutrition and Health in Aging
- Bipolar Disorder and Treatment
- Medical Imaging Techniques and Applications
- Genetic and Kidney Cyst Diseases
- COVID-19 Clinical Research Studies
- Neurological diseases and metabolism
- Genetic Syndromes and Imprinting
- Long-Term Effects of COVID-19
- Neurological disorders and treatments
- Gene expression and cancer classification
- SARS-CoV-2 and COVID-19 Research
- Metabolism, Diabetes, and Cancer
- Frailty in Older Adults
- Genetic Associations and Epidemiology
- EEG and Brain-Computer Interfaces
- Nuclear Receptors and Signaling
- Global Health Care Issues
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
Tehran University of Medical Sciences
2023-2024
Institute for Research in Fundamental Sciences
2023-2024
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been responsible for the recent pandemic since early 2020. Due to wide range of clinical symptoms this disease, from asymptomatic severe and critical forms, it seems that genetic differences among patients, along with other factors (such as gender, age, underlying diseases), can explain part variation in disease symptoms. The TMPRSS2 enzyme plays a vital role stages interaction SARS-CoV-2 host cells by facilitating viral entry....
Abstract Polycystic liver disease (PLD) is a rare condition observed in three genetic diseases, including autosomal dominant polycystic (ADPLD), kidney (ADPKD), and recessive (ARPKD). PLD usually does not impair function, advanced becomes symptomatic when the enlarged compresses adjacent organs or increases intra-abdominal pressure. Currently, diagnosis of mainly based on imaging, testing required except for complex cases. Besides, may help predict patients’ prognosis, classify patients...
Mild Cognitive Impairment (MCI) is a neurological condition characterized by noticeable decline in cognitive abilities that falls between normal aging and dementia. Along with some biomarkers like GAP-43, Aβ, tau, P-tau, brain activity connectivity are ascribed to MCI; however, the link changes such MCI still being investigated. This study explores relationship connectivity. We enrolled 25 Participants function 23 patients MCI. Levels of Aβ1-42, t-tau, p-tau181p CSF were measured, functional...
Abstract Background Alzheimer's disease (AD) is a heritable neurodegenerative whose long asymptomatic phase makes the early diagnosis of it pivotal. Blood U-p53 has recently emerged as superior predictive biomarker for AD in stages. We hypothesized that genetic variants associated with blood could reveal novel loci and pathways involved stages AD. Results performed Genome-wide association study (GWAS) on 484 healthy mild cognitively impaired subjects from ADNI cohort using 612,843 Single...
The term "geriatric giants" refers to the chronic disabilities of senescence leading adverse health outcomes. This study aimed investigate prevalence and predictors geriatric giants in Southern Iran. participants were selected from Bushehr city using a multistage cluster random sampling method. Demographic data collected through interviews. Frailty, incontinence, immobility, depression, cognitive impairment, malnutrition measured by questionnaires instruments. Finally, 2392 analyzed. fecal...
Abstract Background Striatal dopamine transporter (DAT) binding is a sensitive and specific endophenotype for detecting dopaminergic deficits across Parkinson’s disease (PD) spectrum. Molecular clinical signatures of PD in asymptomatic phases help understand the earliest pathophysiological mechanisms underlying disease. We aimed to investigate whether blood epigenetic markers are associated with inter-individual variation striatal DAT among healthy elderly individuals. also investigated this...
<title>Abstract</title> Background Alzheimer's disease (AD) is a heritable neurodegenerative whose long asymptomatic phase makes the early diagnosis of it pivotal. Blood U-p53 has emerged as superior predictive biomarker for AD in stages. We hypothesized that genetic variants associated with blood could reveal novel loci and pathways involved stages AD. Results performed Genome-wide association study (GWAS) on 484 healthy mild cognitively impaired subjects from ADNI cohort using 612,843...
Despite remarkable progress in identifying Parkinson's disease (PD) genetic risk loci, the basis of PD remains largely unknown. With help endophenotype approach and using data from dopamine transporter single-photon emission computerized tomography (DaTscan), we identified potentially involved genes PD.We conducted an imaging study by performing exome-wide association (EWAS) genome-wide (GWAS) on specific binding ratio (SBR) six DaTscan anatomical areas between 489 559 subjects progression...