A5007826118- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Epilepsy research and treatment
- Multiple Sclerosis Research Studies
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects and Toxicity Studies
- Nuclear Receptors and Signaling
- Health, Environment, Cognitive Aging
- Memory and Neural Mechanisms
- RNA regulation and disease
- COVID-19 and Mental Health
- Sleep and related disorders
- Neural dynamics and brain function
- Psychosomatic Disorders and Their Treatments
- Ion channel regulation and function
- Polyomavirus and related diseases
Tehran University of Medical Sciences
2017-2025
University of Maryland, Baltimore
2023-2025
Yale University
2024-2025
University of Tehran
2025
Iranian Orthopedic Association
2017-2024
Imam Khomeini Hospital
2022-2024
University of Maryland, College Park
2024
Alzheimer’s Disease Neuroimaging Initiative
2023
Universal Scientific Education and Research Network
2017-2020
Background: Alzheimer's disease (AD) is a progressive neurodegenerative condition with rising prevalence due to the aging global population. Existing methods for diagnosing AD are struggling detect in its earliest and most treatable stages. One early indicator of substantial decrease brain’s glucose metabolism. Metabolomics can metabolic disturbances biofluids, which may be advantageous detection some ADrelated changes. The study aims predict brain hypometabolism using metabolomics findings...
ABSTRACT Background and Aims Alzheimer's disease (AD) is a widespread neurodegenerative condition that has growing impact on global scale. This study aims to examine the relationship between cerebral blood flow (CBF) synaptic biomarker growth‐associated protein 43 (GAP‐43) through utilization of arterial spin labeling (ASL). The research identified noteworthy correlations cerebrospinal fluid (CSF) GAP‐43 levels, CBF, cognitive composite scores, especially among participants with mild...
Schizophrenia affects approximately 1% of the population worldwide. Multifactorial reasons, ranging from drug resistance to adverse effects medications, have necessitated exploring further therapeutic options. Intermittent theta burst stimulation (iTBS) is a novel high-frequency form transcranial magnetic stimulation, safe procedure with minor faster and longer-lasting poststimulation potential role in treating symptoms; however, exact target brain regions symptoms are still controversial....
Mild Cognitive Impairment (MCI) is a neurological condition characterized by noticeable decline in cognitive abilities that falls between normal aging and dementia. Along with some biomarkers like GAP-43, Aβ, tau, P-tau, brain activity connectivity are ascribed to MCI; however, the link changes such MCI still being investigated. This study explores relationship connectivity. We enrolled 25 Participants function 23 patients MCI. Levels of Aβ1-42, t-tau, p-tau181p CSF were measured, functional...
Neurofilament light chain (NFL) has been recently introduced as a biomarker of early dementia. 18-Fluorodeoxyglucose positron emission tomography (18F-FDG-PET) is proxy for regional hypometabolism in Alzheimer disease (AD). Globally normalized 18F-FDG-PET values and levels NFL tau were obtained from 149 patients with mild cognitive impairment (MCI) the baseline cohort Alzheimer's Disease Neuroimaging Initiative database. We adopted stepwise partial correlation model using plasma NFL, tau,...
According to recent studies, amyloid-β (Aβ) isoforms as cerebrospinal fluid (CSF) biomarkers have remarkable predictive value for cognitive decline in the early stages of Alzheimer's disease (AD). Herein, we aimed investigate correlations between several targeted proteomics CSF samples with Aβ ratios and scores patients AD spectrum search potential diagnostic utility. A total 719 participants were found eligible inclusion. Patients then categorized into cognitively normal (CN), mild...
Purpose: Expertise is the product of training. Few studies have used functional connectivity or conventional diffusometric methods to identify neural underpinnings chess expertise. Diffusometric variables white matter might reflect these adaptive changes, along with changes in structural connectivity, which a sensitive measure microstructural changes. Method: 29 professional players and age-sex matched controls were extracted for regions based on John Hopkin's Mori atlas partially correlated...
The ALS diagnostic challenges necessitate more robust and prognostic methods. A potential biomarker in this regard is the alterations of ferritin levels serum CSF patients compared to controls.The were measured 50 cases control with predefined exclusion criteria. ELISA method was utilized for laboratory measurement statistically analyzed using SPSS.Heightened not significant. However, significantly higher (P < 0.001). Serum negatively correlated disease duration = 0.015) positively...
Considering the difficulties of differentiating Parkinson's disease (PD) from drug-induced Parkinsonism (DIP) in patients receiving antipsychotics, developing robust diagnostic tools is essential. Herein, we used metaiodobenzylguanidine (MIBG) scan to assess its accuracy for this purpose.44 DIP and 32 with PD as controls were enrolled. All participants underwent a cardiac 131I-MIBG scan. Statistical analysis was conducted determine significance results, analyses calculate related sensitivity...
While cerebrospinal fluid (CSF) core biomarkers have been considered diagnostic for a long time, special attention has recently dedicated to lipoproteins and metabolites that could be potentially associated with Alzheimer's disease (AD) neurodegeneration. Herein, we aimed investigate the relationship between levels of CSF including Aβ-42, TAU, P-TAU plasma patients AD from baseline cohort Disease Neuroimaging Initiative (ADNI) database. Using ADNI database, fourteen subclasses as well number...
Abstract The plasma neurofilament light chain (NfL), an axonal cytoskeleton protein, increases in Alzheimer’s disease and was therefore proposed as a blood-based biomarker of the disease. Tensor-based morphometry (TBM) is MR based modality that identifies local volume changes brain. Herein, we aimed to investigate whether NfL measures can predict TBM findings derived from temporal lobe brain one-year follow-up which cognitive function. A total 480 participants with (AD), mild impairment...
Abstract Background and aims The nonmotor symptoms (NMS) of Parkinson's disease (PD) their potential role in early diagnosis are recent debates. Herein, we aimed to investigate the association between depression NMS PD including sleep disorders, hyposexuality, hyposmia, constipation, orthostatic hypotension. Methods A total 93 patients with 67 without were included study, compared two groups. Furthermore, possible associations severity measured by Beck Depression Inventory (BDI) investigated...