A5098828996- Dementia and Cognitive Impairment Research
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Metabolomics and Mass Spectrometry Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Functional Brain Connectivity Studies
- Nuclear Receptors and Signaling
- Advanced Neuroimaging Techniques and Applications
Hormozgan University of Medical Sciences
2024-2025
Background: Alzheimer's disease (AD) is a progressive neurodegenerative condition with rising prevalence due to the aging global population. Existing methods for diagnosing AD are struggling detect in its earliest and most treatable stages. One early indicator of substantial decrease brain’s glucose metabolism. Metabolomics can metabolic disturbances biofluids, which may be advantageous detection some ADrelated changes. The study aims predict brain hypometabolism using metabolomics findings...
<title>Abstract</title> Background Alzheimer's disease (AD) is a global health concern with rising prevalence. Growth Associated Protein 43 (GAP-43) crucial protein for neuronal growth and synaptic plasticity, essential maintaining healthy brain function. In AD, changes in GAP-43 levels have been observed, potentially indicating dysfunction neurodegeneration. This study investigates the potential of as biomarker AD by analyzing its correlation amyloid-beta (Aβ) pathology, hallmark feature...
<title>Abstract</title> Background Alzheimer's Disease (AD) causes multi-domain cognitive decline. Brain imaging biomarkers and neuropsychiatric testing detect difficulties, although it is unclear how processes medial temporal lobe subregions relate. High-resolution T2 MRIs of AD patients' lobes were compared to composite scores for memory, language, executive function, visuospatial ability. Methods 156 Neuroimaging Initiative (ADNI) participants provided data. Composite high-resolution MRI...