A5043588001- Research on Leishmaniasis Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Sirtuins and Resveratrol in Medicine
- COVID-19 Clinical Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Trypanosoma species research and implications
- Adipose Tissue and Metabolism
- Computational Drug Discovery Methods
- Metabolomics and Mass Spectrometry Studies
- Reproductive System and Pregnancy
- Obstructive Sleep Apnea Research
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Glutathione Transferases and Polymorphisms
- Pregnancy and preeclampsia studies
- Metabolism, Diabetes, and Cancer
- Long-Term Effects of COVID-19
- Epigenetics and DNA Methylation
- Effects and risks of endocrine disrupting chemicals
- Plant Pathogens and Fungal Diseases
- Biochemical effects in animals
- Vitamin C and Antioxidants Research
Zanjan University of Medical Sciences
2020-2024
Tehran University of Medical Sciences
2015-2020
Shahid Beheshti University of Medical Sciences
2020
Zero to Three
2018
Cancer is identified as second leading causes of death and imposes a significant psychological economic burden on societies. Due to its high prevalence, main cause worldwide, there continuing need discover new potential anticancer compounds. Plant-derived compounds have recently attracted more attention among researchers for their potent anti-cancer properties. A numerous research, including in-vitro, in-vivo, preclinical, clinical, epidemiological studies, has indicated that the flavonoid...
Summary The gene Nrf2 (nuclear factor‐erythroid 2‐related factor 2) is the most important regulator of cellular antioxidant system and its dysregulation has a role in etiology nonalcoholic fatty liver disease (NAFLD). aim this study was to investigate association between targeted miRNAs (miR‐27a, miR‐142‐5p, miR‐153, miR‐128) with lipid accumulation vitro vivo models NAFLD. We used two expression genes assessed by real‐time PCR protein level evaluated using western blot. To potential NAFLD,...
Background: Oral cancer is a frequently encountered neoplasm of the head and neck region, being eight most common type human malignancy worldwide. Despite improvement in its control, morbidity mortality rates have improved little past decades. Therefore, prevention and/or early detection are high priority. Proteomics with network analysis emerged as powerful tool to identify important proteins associated development progression that can be potential targets for diagnosis. In present study,...
The present study was designed to evaluate the effects of resveratrol, atorvastatin, and a combination resveratrol atorvastatin on expression levels genes involved in cholesterol metabolic pathway fatty liver C57/BL6 mice. A high-fat diet used induce mice treated with or atorvastatin. Pathological biochemical studies were performed. In addition, hepatic gene expressions ATP-binding cassette transporter A1 (ABCA1), ABCG1, X receptor (LXR)α, scavenger B1 (SR-B1), low-density lipoprotein...
Background: Oral cancer is a frequently encountered neoplasm of the head and neck region, being eighth most common type human malignancy worldwide. Despite improvement in its control, morbidity mortality, rates have improved little past decades. The present investigations about gene interaction pathways still could not clear appearance development oral squamous cell carcinoma (OSCC), completely. aim this study to investigate key genes microRNAs OSCC. Materials Methods: microarray datasets...
Invasive ductal carcinoma (IDC) is the most common type of breast cancer so its early detection can lead to a significant decrease in mortality rate. However, prognostic factors for IDC are not adequate and we need novel markers treatment different individuals. Although positron emission tomography magnetic resonance imaging techniques available, they based on morphological features that do provide any clue molecular events accompanying progression. In recent years, "omics" approaches have...
Here, we aimed to investigate whether the beneficial effects of metformin on lipid accumulation is mediated through regulation miR-33b.The expression genes and miRNAs protein levels were evaluated using real-time PCR western blot, respectively. To potential role miR-33b in accumulation, mimic was transfected into HepG2 cells.We found that reduces high glucose-induced cells inhibiting SREBP1c FAS increasing CPT1 CROT. Overexpression significantly prevented decreasing effect content intra...
Wheat take-all disease, caused by Gaeumannomyces graminis var tritici (Ggt), has been observed in different areas of Iran recent years. Current biocontrol studies have confirmed the effectiveness Trichoderma species against many fungal phytopathogens. In this study, effects isolates were evaluated pathogen. Five (Trichoderma virens T65, T90, T96, T122 and koningii T77) selected after screening tests for antifungal pathogen three koningiopsis T149, brevicompactum T146 viridecens T150) used as...
Gastric ulcer is one of the most prevalent diseases worldwide. In Iranian folk medicine, Achillea wilhelmsii (AW) used as a treatment for gastric ulcer. Previous reports also mentioned Antiulcerogenic properties this herbal plant. This study investigated therapeutic effects C. Koch extract on indomethacin-induced lesion in rats, from both proteomic and metabolomic perspectives. The rats were divided into 4 groups. ulceration was induced by single dose indomethacin (45 mg/kg) oral gavage. An...
Background: Although leishmaniasis is regarded as a public health problem, no effective vaccine or decisive treatment has been introduced for this disease. Therefore, representing novel therapeutic proteins essential. Protein-protein Interaction network analysis suitable tool to discover drug targets leishmania major. To aim, gene and protein expression data used instructing the key are highlighted.Materials Methods: In computational bioinformatics study, protein/gene related major were...