A5006320967- Pharmacological Effects of Medicinal Plants
- Alzheimer's disease research and treatments
- Synthesis and biological activity
- Bone Metabolism and Diseases
- Click Chemistry and Applications
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Sleep and related disorders
- Neurogenesis and neuroplasticity mechanisms
- Cancer, Lipids, and Metabolism
- Synthesis and Characterization of Heterocyclic Compounds
- Folate and B Vitamins Research
- Biochemical effects in animals
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Retinoids in leukemia and cellular processes
- Liver Disease Diagnosis and Treatment
- Aluminum toxicity and tolerance in plants and animals
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Covalent Organic Framework Applications
- RNA modifications and cancer
- Sirtuins and Resveratrol in Medicine
- PI3K/AKT/mTOR signaling in cancer
Shahid Beheshti University of Medical Sciences
2016-2025
Shahid Beheshti University
2018-2023
Royan Institute
2023
Academic Center for Education, Culture and Research
2023
University of Tehran
2010-2019
Glioblastoma multiforme (GBM) is one of the deadliest cancers. Temozolomide (TMZ) most common chemotherapy used for GBM patients. Recently, combination strategies have had more effective antitumor effects and focus on slowing down development resistance. A TMZ cholesterol-lowering medications (statins) currently under investigation in vivo clinical trials. In our current investigation, we a triple-combination therapy TMZ, Simvastatin (Simva), acetylshikonin, investigated its apoptotic...
In an attempt to find novel, potent α-glucosidase inhibitors, a library of poly-substituted 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines 3a-ag have been synthesized through heating mixture 2-aminobenzimidazoles 1 and α-azidochalcone 2 under the mild conditions. This efficient, facile protocol has resulted into desirable compounds with wide substrate scope in good excellent yields. Afterwards, their inhibitory activities against yeast enzyme were investigated. Showing IC
Exosomes are natural membrane-enclosed nanovesicles (30–150 nm) involved in cell-cell communication. Recently, they have garnered considerable interest as nanocarriers for the controlled transfer of therapeutic agents to cells. Here, exosomes were derived from bone marrow mesenchymal stem cells using three different isolation methods. Relative filtration and spin column condensation, size exclusion chromatography led with highest purity. These then hybridized liposomes freeze-thaw cycles...
Prevention and/or management of the dysregulated immune response in patients with COVID-19 is expected to help treatment COVID-19. Boswellic acids (BAs) have great therapeutic potential because they anti-inflammatory and immunomodulatory effects. Here, we aimed investigate mechanism action a BA formulation, Inflawell syrup, which was previously shown be effective reducing disease symptoms who suffer from mild moderate Patients were treated either containing boswellic or placebo for 14 days....
Experimental autoimmune encephalomyelitis (EAE) as an experimental model of multiple sclerosis (MS) is characterized by demyelination, infiltration inflammatory cells into the nervous system and dysregulation serum cytokines. We investigated correlation cytokines other markers with EAE pathogenesis. After induction, levels different cytokine/inflammatory mediators were measured. Furthermore, motor functions, myelination, lymphocyte in mice also assessed. Our results revealed that...
The most aggressive form of breast cancer (BC) is Triple-Negative BC (TNBC), with the poorest prognosis, accounting for nearly 15% all cases. Since there no effective treatment, novel strategies, especially targeted therapies, are essential to treat TNBC. Exosomes nano-sized microvesicles derived from cells and transport various intracellular cargoes, including microRNAs (miRNAs). MiRNAs, small non-coding RNA, an influential factor in development cancerous transformations cells.
A Beta 1‐42 and bind by electron microscopy (View interaction)
There is some evidence that cytokines may play an important role in sleep deprivation; however, the underlying mechanisms are still unknown. So, present study aimed to evaluate relationship between NOD-like receptor protein 1 (NLRP1) and 3 (NLRP3) inflammasome activation of blood cells serum levels individuals with chronic insomnia disorder (CID).Blood samples were collected from 24 CID healthy volunteers. The was evaluated using real-time polymerase chain reaction NLRP1, NLRP3,...
The present study was designed to evaluate the effects of resveratrol, atorvastatin, and a combination resveratrol atorvastatin on expression levels genes involved in cholesterol metabolic pathway fatty liver C57/BL6 mice. A high-fat diet used induce mice treated with or atorvastatin. Pathological biochemical studies were performed. In addition, hepatic gene expressions ATP-binding cassette transporter A1 (ABCA1), ABCG1, X receptor (LXR)α, scavenger B1 (SR-B1), low-density lipoprotein...
<span style="color: #1f497d;">Introduction: Beta-Boswellic acid (BBA) is a pentacyclic terpene which has been obtained from frankincense and its beneficial effects on neurodegenerative disorders such as Alzheimer’s disease (AD) have addressed.<br /> #1f497d;">Methods: In the present study, thermodynamic kinetic aspects of BBA interaction with Tau protein one important proteins involved in AD absence presence glucose investigated using surface plasmon resonance (SPR) method....
Glioblastoma multiforme (GBM) is one of the deadliest cancers. Temozolomide (TMZ) most common chemotherapy used for GBM patients. Recently, combination strategies have more effective antitumor effects and focus on slowing down development resistance. A TMZ cholesterol lowering medications (statins) currently under investigation in vivo clinical trials. In our current investigation, we a triple therapy TMZ, Simvastatin (Simva), Acetylshikonin (ASH) investigated its apoptotic mechanism cell...