A5081962010- Protein Interaction Studies and Fluorescence Analysis
- Pharmacological Effects of Medicinal Plants
- Drug Transport and Resistance Mechanisms
- Lipid Membrane Structure and Behavior
- Pharmacogenetics and Drug Metabolism
- Computational Drug Discovery Methods
- Bone Metabolism and Diseases
- Antibiotics Pharmacokinetics and Efficacy
- Protein Hydrolysis and Bioactive Peptides
- Biochemical effects in animals
- Surfactants and Colloidal Systems
- Drug Solubulity and Delivery Systems
- Spectroscopy Techniques in Biomedical and Chemical Research
- Natural product bioactivities and synthesis
- Analytical Chemistry and Chromatography
- Biochemical Analysis and Sensing Techniques
- Alzheimer's disease research and treatments
Tabriz University of Medical Sciences
2013-2024
Detailed information about the relationships between structures and properties/activities of peptides as drugs nutrients is useful in development functional foods containing active compounds. The bitterness an undesirable property which should be reduced during drug/nutrient production, quantitative structure bitter taste relationship (QSBR) studies can help researchers to design less with higher target efficiency. Calculated structural parameters were used develop three different QSBR...
<span style="color: #1f497d;">Introduction: Beta-Boswellic acid (BBA) is a pentacyclic terpene which has been obtained from frankincense and its beneficial effects on neurodegenerative disorders such as Alzheimer’s disease (AD) have addressed.<br /> #1f497d;">Methods: In the present study, thermodynamic kinetic aspects of BBA interaction with Tau protein one important proteins involved in AD absence presence glucose investigated using surface plasmon resonance (SPR) method....
Biological activity of Boswellia extract (BE) has been attributed to its main active ingredients; i.e. Boswellic acids (BAs). BE/BAs possess a promising therapeutic potential in neurodegenerative disorders; including Alzheimer's disease (AD). The multifactorial nature AD pathophysiology necessitates the development disease-modifying agents (DMA). Recent multi-targeting approaches for DMAs have brought more attention plant-derived compounds regarding their better human compatibility because...
The molecular mechanism and thermodynamic properties of the interaction between diltiazem (DTZ) human serum albumin (HSA), has been studied in vitro using spectroscopic techniques (UV-Vis, fluorescence, FTIR), docking methods. effect acidic basic pH, glucose, urea, metal ions on DTZ-HSA binding investigated as well. According to results, there is a 1:1 DTZ HSA, while quenching static up 313 K. apparent constant was 2.09 × 106M-1 that indicates strong HSA. increased pH its slowly decreased...
The molecular mechanism of interaction between Mefenamic acid (MA) and human serum albumin (HSA) was investigated.UV-Visible absorption, fluorescence, FT-IR spectroscopies, with docking, have been used for assay complex formation, quenching study, thermodynamic evaluations, details the mechanism.The constant (Ksv) 1.51×10 5 M -1 obtained, while results are indicating dynamic number binding sites (n) apparent constants (KA) were 1.51 6.55×10 7 , respectively that resembles positive...
Introduction: Fingolimod is a drug that used to treat multiple sclerosis (MS). It has pH-dependent solubility and low when buffering agents are present. Multi-spectroscopic molecular modeling methods were investigate the mechanism of interaction with human serum albumin (HSA), resulting data fitted appropriate models interaction, binding constant, thermodynamic properties. Methods: The HSA was investigated in NaCl aqueous solution (0.1 mM). working solutions had pH 6.5. Data collected using...
Study of interaction between nicotinamide and human serum albumin using spectroscopic techniques molecular docking simulation