A5048534510- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Biochemical effects in animals
- Computational Drug Discovery Methods
- Ferroptosis and cancer prognosis
- Advanced Proteomics Techniques and Applications
- Chronic Kidney Disease and Diabetes
- Gut microbiota and health
- Essential Oils and Antimicrobial Activity
- Ubiquitin and proteasome pathways
- Herbal Medicine Research Studies
- MicroRNA in disease regulation
- Silymarin and Mushroom Poisoning
- Nutrition, Genetics, and Disease
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Renal Diseases and Glomerulopathies
- Bone health and treatments
- Biomarkers in Disease Mechanisms
- Sirtuins and Resveratrol in Medicine
- Alzheimer's disease research and treatments
- Berberine and alkaloids research
- Machine Learning in Bioinformatics
Shahid Beheshti University of Medical Sciences
2015-2025
Cancer is identified as second leading causes of death and imposes a significant psychological economic burden on societies. Due to its high prevalence, main cause worldwide, there continuing need discover new potential anticancer compounds. Plant-derived compounds have recently attracted more attention among researchers for their potent anti-cancer properties. A numerous research, including in-vitro, in-vivo, preclinical, clinical, epidemiological studies, has indicated that the flavonoid...
Thyroid carcinoma is the most common endocrine system malignancy with a fast rising incidence in last decade for unknown reasons. Fine needle aspiration (FNA) biopsy, gold standard thyroid cancer (TC) screening has still its own challenges and some cases needs proceeding surgery.This review highlights role of two recent "omics" approaches, "metabolomics" "lipidomics", field TC research.All previous studies have been extracted from literature major concepts were detailed metabolomics...
Hepatocellular carcinoma (HCC), the most common form of liver cancer, has a significant mortality rate, largely due to late diagnosis. Recent advances in medical research have demonstrated potential biomarkers for early detection. Moreover, discovery and use prognostic offer ray hope fight against cancer. Three gene transcript collections (GSE57957, GSE76427, GSE84402) were retrieved from GEO database, significantly expressed genes identified through comprehensive screening process....
Invasive ductal carcinoma (IDC) is the most common type of breast cancer so its early detection can lead to a significant decrease in mortality rate. However, prognostic factors for IDC are not adequate and we need novel markers treatment different individuals. Although positron emission tomography magnetic resonance imaging techniques available, they based on morphological features that do provide any clue molecular events accompanying progression. In recent years, "omics" approaches have...
Thyroid carcinomas have comprised the fastest rising incidence of cancer in past decade. Currently, diagnosis thyroid tumors is performed by fine-needle aspiration biopsy (FNAB) method, which still holds some challenges and limitations, mostly discriminating malignant benign lesions. Therefore, development molecular markers to distinguish between these lesion types are progress.A 2D-PAGE separation proteins was followed tandem mass spectrometry with aim discovering potential serum protein...
As the most prevalent endocrine system malignancy, papillary thyroid carcinoma had a very fast rising incidence in recent years for unknown reasons besides fact that current methods cancer diagnosis still hold some limitations. Therefore, aim of this study was to improve potential molecular markers benign and malignant nodules prevent unnecessary surgeries tumors.In study, 1H-NMR metabolomics platform used seek discriminating serum metabolites (PTC) compared multinodular goiter (MNG) healthy...
Gastric ulcer is one of the most prevalent diseases worldwide. In Iranian folk medicine, Achillea wilhelmsii (AW) used as a treatment for gastric ulcer. Previous reports also mentioned Antiulcerogenic properties this herbal plant. This study investigated therapeutic effects C. Koch extract on indomethacin-induced lesion in rats, from both proteomic and metabolomic perspectives. The rats were divided into 4 groups. ulceration was induced by single dose indomethacin (45 mg/kg) oral gavage. An...
Gastric cancer (GC) is a prevalent malignancy with high recurrence. Advances in systems biology have identified molecular pathways and biomarkers. This study focuses on discovering gene miRNA biomarkers for diagnosing predicting survival GC patients. Three sets of genes (GSE19826, GSE81948, GSE112369) two expression (GSE26595, GSE78775) were obtained from the Gene Expression Omnibus (GEO), subsequently, differentially expressed (DEGs) miRNAs (DEMs) identified. Functional pathway enrichment,...
Survey of potential diagnostic metabolite markers in serum the rat model Alzheimer's disease using nuclear magnatic resonance (1H-NMR) technique