A5017771287- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Cardiac, Anesthesia and Surgical Outcomes
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Dialysis and Renal Disease Management
- Renal and Vascular Pathologies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sepsis Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Cardiac and Coronary Surgery Techniques
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Hemodynamic Monitoring and Therapy
- Neurological Complications and Syndromes
- Liver Disease and Transplantation
- Cardiac Ischemia and Reperfusion
- Statistical Methods in Clinical Trials
- Congenital Heart Disease Studies
- Metabolism and Genetic Disorders
- Renal function and acid-base balance
- Blood Pressure and Hypertension Studies
- Renal Diseases and Glomerulopathies
- Macrophage Migration Inhibitory Factor
Johns Hopkins Medicine
2018-2025
Johns Hopkins University
2018-2025
University of Catania
2021
AVL (France)
2021
Centre Hospitalier Saint-Nazaire
2021
Yale University
2012-2019
Duke University
2012-2019
University of Michigan
2019
Johns Hopkins All Children's Hospital
2019
Dartmouth Institute for Health Policy and Clinical Practice
2019
Acute kidney injury (AKI) is a frequent complication of cardiac surgery and increases morbidity mortality. The identification reliable biomarkers that allow earlier diagnosis AKI in the postoperative period may increase success therapeutic interventions. Here, we conducted prospective, multicenter cohort study involving 1219 adults undergoing to evaluate whether early measures urine IL-18, neutrophil gelatinase-associated lipocalin (NGAL), or plasma NGAL could identify which patients would...
Objective: To determine the incidence, severity, and risk factors of acute kidney injury in children undergoing cardiac surgery for congenital heart defects. Design: Prospective observational multicenter cohort study. Setting: Three pediatric intensive care units at academic centers. Patients: hundred eleven between ages 1 month 18 yrs surgery. Interventions: None. Measurements Main Results: Acute was defined as a ≥50% increase serum creatinine from preoperative value. Secondary outcomes...
Acute kidney injury (AKI) occurs commonly after pediatric cardiac surgery and associates with poor outcomes. Biomarkers may help the prediction or early identification of AKI, potentially increasing opportunities for therapeutic interventions. Here, we conducted a prospective, multicenter cohort study involving 311 children undergoing congenital lesions to evaluate whether postoperative measures urine IL-18, neutrophil gelatinase-associated lipocalin (NGAL), plasma NGAL could identify which...
Acute kidney injury (AKI) is common in patients with cirrhosis and associated significant mortality. The most etiologies of AKI this setting are prerenal azotemia (PRA), acute tubular necrosis (ATN), hepatorenal syndrome (HRS). Accurately distinguishing the etiology critical, as treatments differ markedly. However, establishing an accurate differential diagnosis extremely challenging. Urinary biomarkers distinguish structural from functional causes may facilitate more rapid diagnoses. We...
Being able to predict whether AKI will progress could improve monitoring and care, guide patient counseling, assist with enrollment into trials of treatment. Using samples from the Translational Research Investigating Biomarker Endpoints in study (TRIBE-AKI), we evaluated kidney injury biomarkers measured at time first clinical diagnosis early after cardiac surgery can forecast severity. Biomarkers included urinary IL-18, albumin creatinine ratio (ACR), plasma neutrophil...
Summary Background and objectives AKI is common novel biomarkers may help provide earlier diagnosis prognosis of in the postoperative period. Design, setting, participants, & measurements This was a prospective, multicenter cohort study involving 1219 adults 311 children consecutively enrolled at eight academic medical centers. Performance two urine biomarkers, kidney injury molecule-1 (KIM-1) liver fatty acid-binding protein (L-FABP), alone or combination with other during perioperative...
Inflammation has an integral role in the pathophysiology of AKI. We investigated associations two biomarkers inflammation, plasma IL-6 and IL-10, with AKI mortality adults undergoing cardiac surgery. Patients were enrolled at six academic centers (n=960). was defined as a ≥50% or ≥0.3-mg/dl increase serum creatinine from baseline. Pre- postoperative IL-10 concentrations categorized into tertiles evaluated for outcomes in-hospital postdischarge all-cause median 3 years after Preoperative not...
Urinary biomarkers of AKI provide prognostic value for in-hospital outcomes, but little is known about their association with longer-term mortality after surgery. We sought to assess the between kidney injury and all-cause in an international, multicenter, prospective long-term follow-up study from six clinical centers United States Canada composed 1199 adults who underwent cardiac surgery 2007 2009 were enrolled Translational Research Biomarker Endpoints cohort. On postoperative days 1–3,...
Background. Knowledge of any harm associated with living kidney donation guides informed consent and donor follow-up. Risk estimates in the literature are variable, most studies did not use a healthy control group to assess outcomes attributable donation. Methods. We observed retrospective cohort using health administrative data for donations which occurred Ontario, Canada between years 1993 2005. There were total 1278 donors 6359 adults who acted as group. Individuals followed mean 6.2...
INTRODUCTION. Acute kidney injury and chronic disease (CKD) are common in hospitalized patients. To inform clinical decision making, more accurate information regarding risk of long-term progression to failure is required.
Acute kidney injury (AKI) after pediatric cardiac surgery is associated with high short-term morbidity and mortality; however, the long-term outcomes are unclear.To assess to determine if perioperative AKI worse outcomes.This prospective multicenter cohort study recruited children between ages 1 month 18 years who underwent cardiopulmonary bypass for survived hospitalization from 3 North American centers July 2007 December 2009. Children were followed up telephone calls an in-person visit at...
Acute kidney injury is a serious complication of elective major surgery. dialysis used to support life in the most severe cases. We examined whether rates and outcomes acute after surgery have changed over time. data from Ontario's universal health care databases study all consecutive patients who had at 118 hospitals between 1995 2009. Our primary were within 14 days surgery, death 90 chronic for did not recover function. A total 552,672 underwent during period, 2231 whom received dialysis....
Assessment of deceased-donor organ quality is integral to transplant allocation practices, but tools more precisely measure donor kidney injury and better predict outcomes are needed. In this study, we assessed associations between biomarkers in urine the following outcomes: AKI (stage 2 or greater), recipient delayed graft function (defined as dialysis first week post-transplant), 6-month eGFR. We measured urinary concentrations microalbumin, neutrophil gelatinase–associated lipocalin...
BACKGROUNDLongitudinal investigations of murine acute kidney injury (AKI) suggest that and inflammation may persist long after the initial insult. However, evolution these processes their prognostic values are unknown in patients with AKI.METHODSIn a prospective cohort 656 participants hospitalized AKI, we measured 7 urine 2 plasma biomarkers injury, inflammation, tubular health at multiple time points from diagnosis to 12 months AKI. We used linear mixed-effect models estimate biomarker...
Recipient outcomes after kidney transplant from deceased donors who received dialysis prior to donation are not well described.