A5058843042- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Imaging and Diagnostics
- Acute Kidney Injury Research
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Ultrasound in Clinical Applications
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac and Coronary Surgery Techniques
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hemodynamic Monitoring and Therapy
- Transplantation: Methods and Outcomes
- COVID-19 and healthcare impacts
- Congenital Heart Disease Studies
- Health and Medical Research Impacts
- Coronary Interventions and Diagnostics
- Cardiac pacing and defibrillation studies
- Diversity and Career in Medicine
- Chronic Kidney Disease and Diabetes
- Heart Failure Treatment and Management
- Pulmonary Hypertension Research and Treatments
Duke Medical Center
2014-2025
Duke University Hospital
2009-2024
Duke University
2014-2024
Atrium Health Wake Forest Baptist
2024
Mount Sinai Medical Center
2024
Christ Hospital
2024
Health Net
2024
Inspire Institute
2021
Icahn School of Medicine at Mount Sinai
2020
Durham Technical Community College
2008-2020
Acute kidney injury (AKI) is a frequent complication of cardiac surgery and increases morbidity mortality. The identification reliable biomarkers that allow earlier diagnosis AKI in the postoperative period may increase success therapeutic interventions. Here, we conducted prospective, multicenter cohort study involving 1219 adults undergoing to evaluate whether early measures urine IL-18, neutrophil gelatinase-associated lipocalin (NGAL), or plasma NGAL could identify which patients would...
Background Pythia is an automated, clinically curated surgical data pipeline and repository housing all patient electronic health record (EHR) from a large, quaternary, multisite institute for science initiatives. In effort to better identify high-risk patients complex data, machine learning project trained on was built predict postoperative complication risk. Methods findings A of outcomes created using automated SQL R code that extracted processed clinical across 37 million encounters the...
Intraoperative transesophageal echocardiography is a standard diagnostic and monitoring tool employed in the management of patients undergoing an entire spectrum cardiac surgical procedures, ranging from "routine" coronary revascularization to complex valve repair, combined organ transplantation. Utilizing protocol as starting point for imaging all procedures enables standardization image acquisition, reduction variability quality reporting, ultimately better patient care. Clear...
Aprotinin has recently been associated with adverse outcomes in patients undergoing cardiac surgery. We reviewed our experience this agent surgery at Duke University Medical Center.We retrieved data on 10,275 consecutive surgical coronary revascularization between January 1, 1996, and December 31, 2005. fit to a logistic-regression model predicting each patient's likelihood of receiving aprotinin the basis preoperative characteristics models long-term survival (up 10 years) decline renal...
Changes in heart transplantation (HT) donor and recipient demographics may influence the incidence of primary graft dysfunction (PGD). We conducted a retrospective study to evaluate PGD incidence, trends, associated risk factors by analyzing consecutive adult patients who underwent HT between January 2009 December 2014 at our institution. Patients were categorized as having using International Society for Heart & Lung Transplantation (ISHLT)-defined criteria. Variables, including clinical...
AKI after cardiac surgery remains strongly associated with mortality and lacks effective treatment or prevention. Preclinical studies suggest that cell-based interventions may influence functional recovery. We conducted a phase 2, randomized, double-blind, placebo-controlled trial in 27 centers across North America to determine the safety efficacy of allogeneic human mesenchymal stem cells (MSCs) reducing time recovery from surgery. randomized 156 adult subjects undergoing evidence early...
Background: Acute kidney injury (AKI) affects up to 30% of patients undergoing cardiac surgery, leading increased in-hospital and long-term morbidity mortality. Teprasiran is a novel small interfering RNA that temporarily inhibits p53-mediated cell death underlies AKI. Methods: This prospective, multicenter, double-blind, randomized, controlled phase 2 trial evaluated the efficacy safety single 10 mg/kg dose teprasiran versus placebo (1:1), in reducing incidence, severity, duration AKI after...
Innovations in cardiac imaging have fundamentally advanced the understanding and treatment of cardiovascular disease. These advances noninvasive also expanded role imager dramatically increased demand for imagers who are cross-trained multiple modalities. However, we hypothesize that there is significant variation availability expertise a disparity adoption technologies across United States. To evaluate this, brought together leaders societies, trainees, as well collaborated with national...
Using either an angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) the morning of surgery may lead to 'functional' postoperative acute kidney injury (AKI), measured by abrupt increase in serum creatinine. Whether same is true for 'structural' AKI, with new urinary biomarkers, unknown. The TRIBE-AKI study was a prospective cohort 1594 adults undergoing cardiac at six hospitals between July 2007 and December 2010. We classified degree exposure ACEi/ARB into...
Background— Acute kidney injury (AKI) after cardiac surgery is associated with poor outcomes and difficult to predict. We conducted a prospective study evaluate whether preoperative brain natriuretic peptide (BNP) levels predict postoperative AKI among patients undergoing surgery. Methods Results— The Translational Research Investigating Biomarker Endpoints in Kidney Injury (TRIBE-AKI) enrolled 1139 adults at 6 hospitals from 2007 2009 who were selected for high risk. Preoperative BNP was...
Background and Purpose— Neurocognitive decline occurs frequently after cardiac surgery persists in a significant number of patients. Magnesium is thought to provide neuroprotection by preservation cellular energy metabolism, blockade the N-methyl-D-aspartate receptor, diminution inflammatory response, inhibition platelet activation. We therefore hypothesized that intraoperative magnesium administration would decrease postoperative cognitive impairment. Methods— After approval Duke University...