A5067507723- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Systemic Sclerosis and Related Diseases
- Chronic Kidney Disease and Diabetes
- Vasculitis and related conditions
- COVID-19 Clinical Research Studies
- Renal and Vascular Pathologies
- Muscle and Compartmental Disorders
- Blood Pressure and Hypertension Studies
- COVID-19 and healthcare impacts
- Advanced Glycation End Products research
- Long-Term Effects of COVID-19
- Cardiovascular Health and Disease Prevention
- Central Venous Catheters and Hemodialysis
- Erythropoietin and Anemia Treatment
- Autoimmune Bullous Skin Diseases
- Organ Donation and Transplantation
- Renal Transplantation Outcomes and Treatments
- Parathyroid Disorders and Treatments
- Cytomegalovirus and herpesvirus research
- Organ and Tissue Transplantation Research
- Vitamin C and Antioxidants Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sepsis Diagnosis and Treatment
Pamukkale University
2014-2024
Ankara University
2023-2024
Istanbul University
2022
Cukurova University
2022
Trakya University
2022
State Hospital
2022
Mersin Üniversitesi
2022
Hacettepe University
2022
Sakarya University
2022
Sağlık Bilimleri Üniversitesi
2020-2021
Clinical studies demonstrate that acute renal failure (ARF) is associated with increased mortality, which may be due to pulmonary complications. ARF affect the lung via production or impaired clearance of mediators injury, such as proinflammatory cytokines. Bilateral nephrectomy a method examine directly deleterious systemic effects absent in without confounding are ischemia-reperfusion injury (e.g., ischemic ARF) toxicity cisplatin-induced ARF). This study contrasts and bilateral on serum...
Fractalkine (CX3CL1) is expressed on injured endothelial cells and a potent chemoattractant adhesion molecule for macrophages carrying the fractalkine receptor (CX3CR1). The aim of this study was to investigate role CX3CL1, its ligand CX3CR1, in ischemic acute renal failure (ARF) mice. On immunoblotting, CX3CL1 protein expression kidney increased markedly ARF. immunofluorescence staining, intensity staining blood vessels significantly more prominent ARF compared with controls. A specific...
Complement activation in the kidney after ischemia/reperfusion (I/R) seems to occur primarily via alternative complement pathway. The ability of an inhibitory mAb mouse factor B, a necessary component pathway, protect mice from ischemic acute renal failure was tested. Treatment with prevented deposition C3b on tubular epithelium and generation systemic C3a I/R. Treated had significantly lower increases serum urea nitrogen developed less morphologic injury For gaining insight into potential...
Inflammatory mechanisms contribute to cisplatin-induced acute renal failure (CisARF). Our first aim was determine macrophage infiltration in CisARF. A more than 2-fold increase CD11b-positive macrophages the kidney on day 2 preceded blood urea nitrogen (BUN) and serum creatinine (SCr). next chemoattractant for Fractalkine (CX<sub>3</sub>CL1) is expressed activated endothelial cells a potent that express its receptor (CX<sub>3</sub>CR1). Immunoblotting showed whole-kidney CX<sub>3</sub>CL1...
Serum cytokines are increased in patients with acute kidney injury (AKI) and predict mortality. It is widely assumed that renal production of the source serum cytokines; role extra-renal cytokine impaired clearance less well studied. We hypothesized AKI was mononuclear phagocyte dependent, independent by kidneys, would be AKI. Bilateral nephrectomy used as a model to assess production. Mononuclear phagocytes were depleted utilizing intravenous (IV) administration liposome-encapsulated...
Acute kidney injury (AKI) is common in coronavirus disease-2019 (COVID-19) and the severity of AKI linked to adverse outcomes. In this study, we investigated factors associated with in-hospital outcomes among hospitalized patients COVID-19 AKI.
The role of caspases and calpain in cisplatin-induced endothelial cell death is unknown. Thus we investigated whether are mediators apoptosis necrosis cells. Cultured pancreatic microvascular (MS1) cells were exposed to 10 50 microM cisplatin. Apoptosis or was determined by Hoechst 33342 propidium iodide (PI) nuclear staining. Cells treated with cisplatin had normal ATP levels, increased caspase-3-like activity, excluded PI demonstrated morphological characteristics at 24 h. severe...
Accelerated atherosclerosis is the major cause of mortality in patients on chronic haemodialysis (HD). Increased oxidative stress might be factor leading to high cardiovascular rate HD patients. The aim our study was clarify effects uraemia and dialysis parameters explore relation between markers carotid artery intima-media thickness (CIMT) as an indicator atherosclerosis.Twenty patients, 20 predialytic uraemic healthy subjects were included study. Serum thiobarbituric acid reactive...
We aimed to assess the correlation between renal apparent diffusion coefficient (ADC) values measured by diffusion-weighted imaging (DWI) and clinical stages of diabetic nephropathy.DWI (b value, 0 600 s/mm2) was performed in 78 patients with clinically confirmed nephropathy (study group) 22 volunteers without diabetes mellitus or any disease (control group). The mean ADCs were calculated from multiple region-of-interest circles positioned cortex. Diabetic categorized into five based on...
Oxidative stress plays a role in many disease states. These diseases have an increased incidence uremia, and particularly hemodialysis (HD) patients. This suggests exposure to oxidative stress. An imbalance between oxidants antioxidants has been suggested uremic patients on HD. However, the respective influence of uremia dialysis procedure not evaluated. It is postulated that antioxidant capacity reduced, yet mechanism remains unclear. We determined levels lipid peroxidation expressed as...
Objectives: Fabry's disease is an X-linked inherited, rare, progressive, lysosomal storage disorder, affecting multiple organs due to the deficient activity of α-galactosidase A (α-Gal A) enzyme. The prevalence has been reported be 0.15–1% in hemodialysis patients; however, information on chronic kidney not dialysis lacking. This study aimed determine disease.Methods: patients older than 18 years, enclosing KDIGO 2012 definitions, dialysis, were enrolled. Dried blood spots Guthrie papers...
Background. Ischemia reperfusion injury leading to acute renal failure (ARF) and delayed graft function is an important problem in organ transplantation. CD4+ T cells, essential for transplant rejection, may mediate ischemic ARF. We have demonstrated that the caspase-1 mediated production of IL-18 pathogenic ARF mice. A potential source cell. therefore examined effect cell depletion on development activation IL-18. Methods. Functional histological correlates were two groups mice with ARF: 1)...
Acute effects of hemodialysis on oxidative stress parameters in chronic uremic patients: Comparison two dialysis membranes H Ibrahim Varan1, Belda Dursun2, Evrim Dursun3, Tomris Ozben3, Gultekin Suleymanlar41Numune Training Hospital, Division Nephrology, Medical School, Adana; 2Division Pamukkale University, Denizli; 3Department Biochemistry, Akdeniz Antalya; 4Division TurkeyAbstract: Uremic state and hemobioincompatibility are implicated subclinical inflammation progression atherosclerosis...
Hemodialysis (HD) patients have increased risk for short-term adverse outcomes of COVID-19. However, complications and survival at the post-COVID-19 period not been published extensively.We conducted a national, multicenter observational study that included adult maintenance HD recovered from confirmed A control group without COVID-19 was selected in same center. We investigated characteristics follow-up compare them with non-COVID-19 group.A total 1223 (635 group, 588 group) 47 centers were...
Abstract Background The largest data on the epidemiology of primary glomerular diseases (PGDs) are obtained from databases countries or centers. Here, we present extended results Primary Glomerular Diseases Study Turkish Society Nephrology (TSN-GOLD) Working Group. Methods Data patients who underwent renal biopsy and received diagnosis PGD were recorded in database prepared for study. A total 4399 47 centers evaluated between May 2009 2019. at time kidney analyzed. After exclusion without...
Oxidative stress has been defined as a loss of balance between free radical production and the antioxidant systems. There have many reports increased oxidants decreased levels antioxidants in chronic renal failure (CRF) patients. An increase oxidative may contribute to development protein damage CRF. Our aim was reveal modifications plasma proteins by measuring 2,4-dinitrophenylhydrazine reactive carbonyl derivates (PCO), thiol (P-SH) reduced glutathione (GSH) predialytic uraemic...
Abstract The data regarding primary FSGS (pFSGS) from different parts of the world differ. While prevalence pFSGS has been increasing in Western countries like USA, it follows an inconsistent trend Europe and Asia a decreasing Far Eastern such as China last two decades. There are undetermined factors to explain those national geographic discrepancies. Herein, we aimed reveal current with clinical histopathological characteristics Turkish adults. This study includes biopsy-proven patients...
Cardiovascular disease is the major cause of death in chronic kidney (CKD) patients. The main underlying reason inflammation. In CKD, interleukin-6 and hypersensitive C-reactive protein are known to be used for evaluation inflammation serum levels increase with decreased creatinine clearance. Neutrophil gelatinase-associated lipocalin (NGAL) hepcidin also considered effective assessment inflammatory conditions. possible interactions NGAL markers CKD patients including transplants, which have...
<b><i>Background:</i></b> Fabry disease (FD) is an X-linked lysosomal storage disorder resulting from lack of alpha-galactosidase A (AGALA) activity in lysosomes. <b><i>Objective:</i></b> In this multicenter study, we aimed to evaluate the prevalence FD renal transplant (Tx) recipients Turkey. We also screened dialysis patients as a control group. <b><i>Methods:</i></b> All Tx and were regardless presence primary...
Background Oxidative stress is a new risk factor for atherosclerosis. Increased oxidative in hemodialysis (HD) patients may arise from uremia-associated metabolic/humoral abnormalities and bioincompatibility of dialysis. Patients with diabetes mellitus (DM) be subject to an additional risk. Respective influences uremia, diabetes, HD duration accelerated atherosclerosis have not been clarified yet. Methods The study was performed on 24 nondiabetic patients, 23 diabetic 20 stages 3 4 chronic...