A5050394632- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Renal and Vascular Pathologies
- Acute Kidney Injury Research
- Neurological Complications and Syndromes
- Palliative Care and End-of-Life Issues
- Cytomegalovirus and herpesvirus research
- Bipolar Disorder and Treatment
- Transplantation: Methods and Outcomes
- Herpesvirus Infections and Treatments
- Parvovirus B19 Infection Studies
- Healthcare Policy and Management
- Renal Diseases and Glomerulopathies
- Reproductive Health and Technologies
- MRI in cancer diagnosis
- Hemoglobinopathies and Related Disorders
- Geriatric Care and Nursing Homes
- Polyomavirus and related diseases
- Grief, Bereavement, and Mental Health
- Hepatitis C virus research
- Chronic Kidney Disease and Diabetes
- Organ and Tissue Transplantation Research
- Parathyroid Disorders and Treatments
- Liver Disease and Transplantation
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2025
Shanghai University of Traditional Chinese Medicine
2025
Saint Barnabas Medical Center
2015-2024
Rutgers, The State University of New Jersey
2013-2021
University of Pennsylvania
2002-2019
Rutgers Sexual and Reproductive Health and Rights
2014
Children's Hospital of Philadelphia
2007
Philadelphia University
2007
Metabolism and Renal Physiology
2005
Center for Clinical Research (United States)
2005
Posttransplant diabetes mellitus (PTDM) remains a common complication of immunosuppression. Although multiple risk factors have been implicated, none clearly identified as predisposing to the increased PTDM frequency observed in patients on tacrolimus. Hepatitis C virus (HCV) has associated with and is significant renal transplant comorbidity. In this study, records 427 kidney recipients who had no known before transplantation were retrospectively examined. A multivariate logistic regression...
Nonadherence to immunosuppressive medications may partly explain the worse allograft outcomes among black recipients of renal transplants. In a prospective cohort study deceased donor transplants, microelectronic cap monitors were placed on bottles one medication ( 1 ) measure average daily percentage adherence during first posttransplantation year and 2 determine factors associated with adherence. A total 278 transplant who provided sufficient data grouped into four categories adherence: 95...
Assessment of deceased-donor organ quality is integral to transplant allocation practices, but tools more precisely measure donor kidney injury and better predict outcomes are needed. In this study, we assessed associations between biomarkers in urine the following outcomes: AKI (stage 2 or greater), recipient delayed graft function (defined as dialysis first week post-transplant), 6-month eGFR. We measured urinary concentrations microalbumin, neutrophil gelatinase–associated lipocalin...
Among kidney transplant recipients, non-adherence with immunosuppressive medications frequently precedes allograft loss. We sought to determine the prevalence and correlates of medication among recipients. performed a single-center, cross-sectional study recipients who were at least 6 months post-transplant. measured self-reported adherence using Immunosuppressive Therapy Adherence Scale (ITAS, which is scored from 0 12, where higher scores indicate increased adherence) barriers Barriers...
Hypothermic machine perfusion (HMP) is increasingly used in deceased donor kidney transplantation, but controversy exists regarding the value of biomarkers and pump parameters for assessing organ quality. We prospectively determined associations between perfusate (neutrophil gelatinase–associated lipocalin [NGAL], injury molecule 1, IL-18 liver-type fatty acid–binding protein [L-FABP]) (resistance flow) with outcomes delayed graft function (DGF) 6-mo estimated GFR (eGFR). DGF occurred 230...
Background and objectives: Lower rates of living donor kidney transplant (LDKT) among candidates who are black or older may stem from lower likelihoods (1) recruiting potential donors (2) actually donating (donor “conversion”). Design, setting, participants, & measurements: A single-center, retrospective cohort study was performed to determine race, age, gender differences in LDKT, recruitment, conversion. Results: Of 1617 candidates, 791 (48.9%) recruited at least one donor, 452 (28.0%)...
Deceased donor kidneys with AKI are often discarded for fear of poor transplant outcomes. Donor biomarkers that predict post-transplant renal recovery could improve organ selection and reduce discard. We tested whether higher levels urinary YKL-40, a repair phase protein, associate improved recipient outcomes in prospective cohort study involving deceased kidney donors from five procurement organizations. measured YKL-40 concentration 1301 (111 had AKI, defined as doubling serum creatinine)...
Background and objectives The influence of deceased-donor AKI on post-transplant outcomes is poorly understood. few published studies about preimplant biopsy have reported conflicting results regarding associations between recipient outcomes. Design, setting, participants, & measurements This multicenter study aimed to evaluate reports acute tubular necrosis (ATN) delayed graft function (DGF), secondarily for death-censored failure, first adjusting the kidney donor risk index then...
Ischemia-reperfusion injury (IRI) leading to delayed graft function (DGF), defined by the United Network for Organ Sharing as dialysis in first week (UNOS-DGF), associates with poor kidney transplant outcomes. Controversies remain, however, about initiation thresholds and utility other criteria denote less severe IRI, or slow (SGF).Multicenter, prospective study of deceased-donor recipients compare UNOS-DGF a definition that combines impaired creatinine reduction 48 hours greater than 1...
Diagnosing perianal fistulizing Crohn's disease (pfCD) typically depends on costly and time-intensive endoscopic radiographic procedures. Compelling evidence indicates that neutrophil gelatinase-associated lipocalin (NGAL) plays a role in the pathophysiology of (CD) may serve as noninvasive biomarker for its diagnosis. This study aimed to evaluate NGAL's potential diagnostic between pfCD cryptoglandular (CG) fistula, correlation with severity pfCD. Serum, fecal, fistula tissue samples were...
Background. The optimal regimen for prophylaxis of cytomegalovirus (CMV) disease after kidney and/or pancreas transplantation remains unclear. We compared the effectiveness three months oral ganciclovir (3 g/day) versus low-dose valganciclovir (450 mg/day) CMV prophylaxis. Methods. performed a retrospective cohort study patients at our center who received transplants between January 2000 and April 2003. used Cox proportional hazards model to examine relationship baseline covariates,...
Accurate and reliable assessment tools are needed in transplantation. The objective of this prospective, multi-center study was to determine the associations alpha pi iso-enzymes glutathione S-transferase (GST), measured from perfusate solution at start end (base post) kidney allograft machine perfusion, with subsequent delayed graft function (DGF). We also compared GST iso-enzyme levels discarded versus transplanted kidneys. A total 428 kidneys were linked outcomes as recorded by United...
De novo post-transplant diabetes mellitus (PTDM) is a common complication after kidney transplant (KT). Most recent studies are single center with various approaches to outcome ascertainment.In multicenter longitudinal cohort of 632 nondiabetic adult recipients transplanted in 2010-2013, we ascertained outcomes through detailed chart review at 13 centers. We hypothesized that donor characteristics, such as sex, HCV infection, and profile index (KDPI), recipient age, race, BMI, increased HLA...
The best treatment option for end-stage renal disease is usually a transplant, preferably live donor kidney transplant (LDKT). most effective ways to educate candidates about the risks, benefits, and process of LDKT remain unknown. We report protocol Enhancing Living Donor Kidney Transplant Education (ELITE) Study, cluster randomized trial an educational intervention be implemented during initial evaluation at large, suburban U.S. center. Five hundred potential are (by date visit) receive...
Tacrolimus is an immunosuppressant frequently used following solid organ transplantation, including renal transplantation. Peripheral neuropathy uncommon neurological side effect of tacrolimus and has rarely been reported in We report a patient who received living-related donor kidney transplant presented with altered mental status new-onset bilateral foot drop. Laboratory tests cerebrospinal fluid excluded infection, MRI the brain showed chronic microvascular ischaemic changes....
Data reported to the Organ Procurement and Transplantation Network (OPTN) are used in kidney transplant research, policy development, assessment of center quality, but accuracy early post-transplant outcome measures is unknown.The Deceased Donor Study (DDS) a prospective cohort study at five centers. Research coordinators manually abstracted data from electronic records for 557 adults who underwent deceased donor transplantation between April 2010 November 2013. We compared outcomes delayed...