A5072950865- Tryptophan and brain disorders
- Pharmacological Effects and Toxicity Studies
- Parkinson's Disease Mechanisms and Treatments
- Pharmacogenetics and Drug Metabolism
- Epigenetics and DNA Methylation
- Telomeres, Telomerase, and Senescence
- Epilepsy research and treatment
- Chromosomal and Genetic Variations
- Bipolar Disorder and Treatment
- Drug Transport and Resistance Mechanisms
- Schizophrenia research and treatment
- Bioinformatics and Genomic Networks
- Nicotinic Acetylcholine Receptors Study
- CRISPR and Genetic Engineering
- dental development and anomalies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Nuclear Receptors and Signaling
- Pluripotent Stem Cells Research
- Genetics and Neurodevelopmental Disorders
- Alzheimer's disease research and treatments
- Drug-Induced Adverse Reactions
- Mental Health Research Topics
- Cannabis and Cannabinoid Research
Instituto Nacional de Neurología y Neurocirugía
2016-2025
The University of Texas Health Science Center at Houston
2016-2017
Universidad Autónoma Metropolitana
2014
Max Planck Research Unit for Neurogenetics
2013
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2005-2008
Institut de génétique et de biologie moléculaire et cellulaire
2006
Canadian Nautical Research Society
2006
Inserm
2006
Eurométropole de Strasbourg
2006
Collège de France
2006
In eukaryotic cells, phosphoinositides are lipid second messengers important for many cellular processes and have been found dysregulated in several human diseases. X-linked myotubular (centronuclear) myopathy is a severe congenital caused by mutations phosphatidylinositol 3-phosphate (PtdIns3P) phosphatase called myotubularin, dominant centronuclear (CNM) cases were identified the dynamin 2 gene. The genes mutated autosomal recessive of CNMs not found. We novel phosphoinositide (hJUMPY)...
Several HLA alleles have been associated with antiepileptic drugs (AEDs)-induced cutaneous adverse drug reactions (cADRs) in different populations; however, this has not investigated Mexican Mestizos (MM). Thus, the purpose of preliminary study was to determine association class I AED-induced cADRs MM patients.This case-control included 21 patients phenytoin (PHT)-, carbamazepine (CBZ)-, or lamotrigine (LTG)-induced maculopapular exanthema (MPE) Stevens-Johnson syndrome (SJS); 31 tolerant...
Pharmacogenetic variation in Latin Americans is understudied, which sets a barrier for the goal of global precision medicine. The RIBEF-CEIBA Network Consortium was established to characterize interindividual and between population variations CYP2D6, CYP2C9, CYP2C19 drug metabolizing enzyme genotypes, were subsequently utilized catalog their "predicted metabolism phenotypes" across Native American Ibero populations. Importantly, we report this study, total 6060 healthy individuals from...
Background/Objectives: Antiseizure drugs (ASDs) are the primary therapy for epilepsy, and choice varies according to seizure type. Epilepsy patients experience chronic mitochondrial oxidative stress increased levels of pro-inflammatory mediators, recognizable hallmarks biological aging; however, few studies have explored aging markers in epilepsy. Herein, we addressed first time impact ASDs on molecular by measuring telomere length (TL) mtDNA copy number (mtDNA-CN). Methods: We used...
Parkinson's disease (PD) pathophysiology includes mitochondrial dysfunction, neuroinflammation, and aging as its biggest risk factors. Mitochondrial DNA copy number (mtDNA-CN) telomere length (TL) are biological markers with inconclusive results regarding their association PD. A case-control study was used to measure TL mtDNA-CN using qPCR in PBMCs. PD patients were naive at baseline (T0) followed-up one (T1) two (T2) years after the dopaminergic treatment (DRT). Plasmatic cytokines...
Suicide represents a major health concern, especially in developing countries. While many demographic risk factors have been proposed, the underlying molecular pathology of suicide remains poorly understood. A body evidence suggests that aberrant DNA methylation and expression is involved. In this study, we examined profiles concordant gene changes prefrontal cortex Mexicans who died by suicide.In collaboration with coroner's office Mexico City, brain samples males (n = 35) age-matched...
Abstract Background: Parkin mutations in patients with early‐onset Parkinson's disease (EOPD) are estimated to occur 49% of familial cases and 18% sporadic cases. Methods: We analyzed the entire sequence‐coding region dosage parkin 63 Mexican‐mestizo EOPD 120 controls. Results: were present 34 (54.0%). Exon rearrangements, predominantly spanning exons 9 12 (31.7% 19.0%, respectively) 32 patients, 17.5% carrying simple heterozygous 25.4% compound mutations. Conclusions: A higher frequency...
Although individuals with substance use disorder (SUD) are at high risk of committing suicide, most studies postmortem gene expression exclude subjects SUD due to the potential confounding effect drugs in transcriptome. Thus, little is known about profile suicides SUD. The identification altered biological processes crucial comprehension interaction between both pathologies.We evaluated dorsolateral prefrontal area and nonsuicides without by microarrays.We identified 222 differentially...
Mutations in PARK2 , PINK1 and DJ‐1 have been associated with autosomal recessive early‐onset Parkinson's disease. Here, we report the prevalence of sequence structural mutations these three main genes Mexican Mestizo patients. The complete sequences were analyzed by homo/heteroduplex DNA formation direct sequencing; exon dosage was determined multiplex ligation‐dependent probe amplification real‐time PCR 127 patients belonging to 122 families 120 healthy controls. All individuals had...
Alzheimer’s disease (AD) is characterized by the presence of neuropsychiatric or behavioral and psychological symptoms dementia (BPSD). BPSD have been associated with APOE_ε4 allele, which also major genetic AD risk factor. Although involvement some circadian genes orexin receptors in sleep disorders has studied psychiatric pathologies, including AD, there are no studies considering gene–gene interactions. The associations one variant PER2, two PER3, OX2R APOE were evaluated 31 patients...