A5059163570- Cancer Cells and Metastasis
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Genomics and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Telomeres, Telomerase, and Senescence
- Nutrition and Health in Aging
- Growth Hormone and Insulin-like Growth Factors
- Microfluidic and Bio-sensing Technologies
- Acute Ischemic Stroke Management
- Genetics, Aging, and Longevity in Model Organisms
- Muscle Physiology and Disorders
- Cardiovascular Disease and Adiposity
- Traumatic Brain Injury and Neurovascular Disturbances
- Spaceflight effects on biology
- Neurological Disease Mechanisms and Treatments
- Single-cell and spatial transcriptomics
- Mitochondrial Function and Pathology
- Eicosanoids and Hypertension Pharmacology
- Metastasis and carcinoma case studies
- Sirtuins and Resveratrol in Medicine
- Regulation of Appetite and Obesity
University of Oklahoma Health Sciences Center
2018-2025
University of Southern California
2011-2024
National Institute of Technology Tiruchirappalli
2020-2023
University of Wisconsin–Madison
2017-2023
Ziopharm Oncology (United States)
2021
The Ohio State University
2008-2020
University of Oklahoma
2020
Columbia University
2016-2017
Leidos (United States)
2014-2017
Frederick National Laboratory for Cancer Research
2013-2017
Mutations in growth signaling pathways extend life span, as well protect against age-dependent DNA damage yeast and decrease insulin resistance cancer mice. To test their effect humans, we monitored for 22 years Ecuadorian individuals who carry mutations the hormone receptor (GHR) gene that lead to severe GHR IGF-1 (insulin-like factor-1) deficiencies. We combined this information with surveys identify cause age of death community died before period. The deficiency exhibited only one...
Chronic activation of β3-adrenergic receptors (β3-ARs) expands the catabolic activity both brown and white adipose tissue by engaging uncoupling protein 1 (UCP1)-dependent UCP1-independent processes. The present work examined de novo lipogenesis (DNL) TG/glycerol dynamics in classic brown, subcutaneous "beige," tissues during sustained β3-AR CL 316,243 (CL) also addressed contribution TG hydrolysis to these dynamics. treatment for 7 days dramatically increased DNL turnover similarly all...
Abstract Chemotherapy‐induced cognitive impairment (“chemobrain”) is a frequent side‐effect in cancer survivors treated with paclitaxel (PTX). The mechanisms responsible for PTX‐induced remain obscure, and there are no effective treatments or prevention strategies. Here, we test the hypothesis that PTX induces endothelial senescence, which impairs microvascular function contributes to genesis of decline. We transgenic p16‐3MR mice, allows detection selective elimination senescent cells, (5...
The optimization of a purely negative depletion, enrichment process for circulating tumor cells (CTCs) in the peripheral blood head and neck cancer patients is presented. uses red cell lysis step followed by immunomagnetic labeling, subsequent CD45 positive cells. A number relevant variables are quantified, or attempted to be which control performance process. Six different labeling combinations were evaluated as well significant difference with respect source: buffy coats purchased from Red...
Circulating tumor cells (CTCs) are commonly isolated from the blood by targeting epithelial cell adhesion molecule (EpCAM) through positive selection. However, EpCAM can be downregulated during metastatic progression, or it initially not present. We designed present prospective trial to characterize CTCs as well other circulating populations in samples women with breast cancer without EpCAM-dependent enrichment and/or isolation technology.A total of 32 patients were enrolled, and processed...
There is strong evidence that obesity has deleterious effects on cognitive function of older adults. Previous preclinical studies demonstrate in aging associated with a heightened state systemic inflammation, which exacerbates blood-brain barrier disruption, promoting neuroinflammation and oxidative stress. To test the hypothesis synergistic inflammatory processes exert hippocampal function, young aged C57BL/6 mice were rendered obese by chronic feeding high-fat diet followed assessment...
Over two-thirds of individuals aged 65 and older are obese or overweight in the United States. Epidemiological data show an association between degree adiposity cognitive dysfunction elderly. In this review, pathophysiological roles microvascular mechanisms, including impaired endothelial function neurovascular coupling responses, rarefaction, blood-brain barrier disruption genesis impairment geriatric obesity considered. The potential contribution adipose-derived factors fundamental...
High-fat diets (HFDs) have pervaded modern dietary habits, characterized by their excessive saturated fat content and low nutritional value. Epidemiological studies compellingly linked HFD consumption to obesity the development of type 2 diabetes mellitus. Moreover, synergistic interplay HFD, obesity, expedites aging process prematurely fosters age-related diseases. However, underlying mechanisms driving these associations remain enigmatic. One most conspicuous hallmarks is accumulation...
Objectives: To present and discuss a high-performance negative depletion method for the isolation of circulating tumor cells (CTCs) in blood patients with head neck cancer to determine correlation between presence CTCs early clinical outcome these patients.Design: Prospective follow-up study squamous cell carcinoma (SCCHN) undergoing surgical intervention, who had peripheral examined CTCs. Patients:The population comprised 48 diagnosed as having SCCHN intervention.Intervention: A process...
Epithelial to mesenchymal transition (EMT) has been hypothesized as a mechanism by which cells change phenotype during carcinogenesis, well tumor metastasis. Whether EMT is involved in cancer metastasis specific, practical impact on the field of circulating (CTCs). Since generally accepted definition CTC includes expression epithelial surface markers, such EpCAM, if cell loses its markers (which suggested EMT), it will not be separated and/or identified CTC. We have developed, and previously...