A5088883256- Glioma Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Diet and metabolism studies
- Cancer-related cognitive impairment studies
- Brain Metastases and Treatment
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- Telomeres, Telomerase, and Senescence
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Microtubule and mitosis dynamics
- Cardiovascular Health and Disease Prevention
- Advanced Electron Microscopy Techniques and Applications
- Dietary Effects on Health
- Skin Protection and Aging
- Cerebrovascular and genetic disorders
- Biochemical effects in animals
- Hair Growth and Disorders
- MRI in cancer diagnosis
- GDF15 and Related Biomarkers
- Synthesis and Characterization of Heterocyclic Compounds
University of Oklahoma Health Sciences Center
2020-2025
Semmelweis University
2023-2025
Oklahoma Medical Research Foundation
2019-2022
Medical University of Lodz
2016-2022
University of Oklahoma
2022
Abstract Chemotherapy‐induced cognitive impairment (“chemobrain”) is a frequent side‐effect in cancer survivors treated with paclitaxel (PTX). The mechanisms responsible for PTX‐induced remain obscure, and there are no effective treatments or prevention strategies. Here, we test the hypothesis that PTX induces endothelial senescence, which impairs microvascular function contributes to genesis of decline. We transgenic p16‐3MR mice, allows detection selective elimination senescent cells, (5...
Abstract Chemotherapy-related cognitive impairment, commonly referred to as “chemobrain,” significantly affects cancer survivors’ quality of life, yet its underlying mechanisms remain unclear. Most chemotherapeutic agents cannot cross the blood–brain barrier (BBB), they cause central nervous system side effects, suggesting alternative pathways toxicity. Given that these drugs interact with cerebrovascular endothelium at their highest concentrations, it is logical hypothesize endothelial...
High-fat diets (HFDs) have pervaded modern dietary habits, characterized by their excessive saturated fat content and low nutritional value. Epidemiological studies compellingly linked HFD consumption to obesity the development of type 2 diabetes mellitus. Moreover, synergistic interplay HFD, obesity, expedites aging process prematurely fosters age-related diseases. However, underlying mechanisms driving these associations remain enigmatic. One most conspicuous hallmarks is accumulation...
Mild cognitive impairment (MCI) is a prodromal stage of dementia. Understanding the mechanistic changes from healthy aging to MCI critical for comprehending disease progression and enabling preventative intervention.
Abstract The increasing number of cancer survivors has brought heightened attention to the side effects therapies, including chemotherapy-related cognitive impairment (CRCI, commonly referred as “chemobrain”). Cisplatin and methotrexate, used first-line chemotherapeutics in gynecologic oncology for cancers such breast, ovarian, bladder cancer, are clinically associated with long-term deficits. Building on our previous preclinical studies demonstrating that paclitaxel chemotherapy induces...
Abstract Chemotherapy-induced cognitive impairment (CICI), commonly referred to as “chemobrain,” is a frequent and debilitating side effect experienced by cancer survivors treated with paclitaxel (PTX). Preclinical models have shown that PTX promotes cerebromicrovascular endothelial cell senescence, leading chronic blood–brain barrier (BBB) disruption neuroinflammation. Conversely, the elimination of senescent cells through senolytic therapies has been restore BBB integrity, reduce...
Intra-vital visualization of deep cerebrovascular structures and blood flow in the aging brain has been a difficult challenge field neurovascular research, especially when considering key role played by cerebrovasculature pathogenesis both vascular cognitive impairment dementia (VCID) Alzheimer’s disease (AD). Traditional imaging methods face difficulties with thicker skull older brains, making high-resolution cerebral (CBF) assessment challenging. However, functional ultrasound (fUS)...
Abstract Introduction Age‐related blood–brain barrier (BBB) disruption, cerebromicrovascular senescence, and microvascular rarefaction substantially contribute to the pathogenesis of vascular cognitive impairment (VCI) Alzheimer's disease (AD). Previous studies established a causal link between age‐related decline in circulating levels insulin‐like growth factor‐1 (IGF‐1), dysfunction, decline. The aim our study was determine effect IGF‐1 signaling on BBB permeability, density middle‐age old...
Chemotherapy-induced cognitive impairment (CICI), often referred to as "chemobrain," significantly affects the quality of life in cancer survivors. Although traditionally attributed neuronal toxicity, emerging evidence suggests a key role cerebrovascular dysfunction its pathogenesis. We hypothesized that paclitaxel (PTX, Taxol) treatment induces long-term dysfunction, including microvascular rarefaction, impaired neurovascular coupling (NVC), and altered cerebral blood flow (CBF), which...
With advancing age, neurovascular dysfunction manifests as impaired coupling (NVC), microvascular rarefaction, and blood-brain barrier (BBB) disruption, contributing to vascular cognitive impairment (VCI). Our previous research established a causal link between senescence induced cerebromicrovascular decline in accelerated aging models. The present study examines whether chronological promotes endothelial senescence, adversely affecting health, senolytic therapies can enhance function...