A5084924216- Growth Hormone and Insulin-like Growth Factors
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Neurological Disease Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Neurogenesis and neuroplasticity mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Pituitary Gland Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
- Regulation of Appetite and Obesity
- Mitochondrial Function and Pathology
- Biochemical effects in animals
- Genomics, phytochemicals, and oxidative stress
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Alzheimer's disease research and treatments
- Spaceflight effects on biology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Hormonal Regulation and Hypertension
- Memory and Neural Mechanisms
- Thyroid Disorders and Treatments
University of Oklahoma Health Sciences Center
2014-2023
University of Oklahoma
2012-2017
Star Center
2011-2016
Wake Forest University
2000-2015
Atrium Health Wake Forest Baptist
1988-2015
Arizona Research Center
2012-2014
University of Illinois Chicago
2012
OU Health
2011
Translational Research in Oncology
2011
Center for Neurosciences
2010
Epidemiological studies suggest that Mediterranean diets rich in resveratrol are associated with reduced risk of coronary artery disease. Resveratrol was also shown to confer vasoprotection animal models type 2 diabetes and aging. However, the mechanisms by which exerts its antioxidative vasculoprotective effects not completely understood. Using a nuclear factor-E(2)-related factor-2 (Nrf2)/antioxidant response element-driven luciferase reporter gene assay, we found cultured arterial...
This paper reviews the key role that Earth Observations (EO) play in achieving Sustainable Development Goals (SDGs) as articulated 2030 Agenda document and monitoring, measuring, reporting on progress towards associated targets. also highlights how Group (GEO) would contribute to ensure actual use of EO support Agenda; Global System Systems meets requirements for efficient investments science technology a good return investment, which is elaborated Addis Ababa Action development financing....
There is growing evidence that obesity has deleterious effects on the brain and cognitive function in elderly population. However, specific mechanisms through which aging interact to promote decline remain unclear. To test hypothesis exacerbates obesity-induced cerebromicrovascular damage neuroinflammation, we compared young (7 months) aged (24 high fat diet–fed obese C57BL/6 mice. Aging exacerbated systemic inflammation blood–brain barrier disruption, as indicated by increased circulating...
There is strong evidence showing that aging associated with vascular oxidative stress, which has been causally linked to the development of cardiovascular diseases. NF-E2-related factor-2 (Nrf2) a transcription factor, activated by reactive oxygen species in vasculature young animals leading upregulation various antioxidant genes. The present study was designed elucidate age-related changes homeostatic role Nrf2-driven free radical detoxification mechanisms vasculature. We found aorta...
Hypertension in the elderly substantially contributes to cerebromicrovascular damage and promotes development of vascular cognitive impairment. Despite importance myogenic mechanism protection, it is not well understood how aging affects functional adaptation cerebral arteries high blood pressure. was induced young (3 months) aged (24 C57/BL6 mice by chronic infusion angiotensin II (AngII). In hypertensive mice, range flow autoregulation extended higher pressure values, pressure-induced tone...
Moment-to-moment adjustment of cerebral blood flow (CBF) via neurovascular coupling has an essential role in maintenance healthy cognitive function. In advanced age, increased oxidative stress and cerebromicrovascular endothelial dysfunction impair coupling, likely contributing to age-related decline higher cortical functions. There is increasing evidence showing that mitochondrial plays a critical range cellular impairments, but its uncoupling remains unexplored. This study was designed...
Several reports have demonstrated that cerebral blood flow decreases with age and may contribute to neurodegenerative changes found in aging animals man. Because GH insulin-like growth factor 1 (IGF-1) decrease an important role vascular maintenance remodeling, we hypothesized the is associated a rarefaction of vessels resulting from decline IGF-1. Measurements density (number vessels/cortical surface area) both Brown-Norway Fisher 344/Brown-Norway rats were made at 5, 13, 29 months using...
Insulin-like growth factor-1 has been found to be involved in the regulation of several aspects brain metabolism, neural transmission, and differentiation. Because decreased insulin-like and/or its receptors are likely contribute age-related abnormalities behavior, strategy replacing this protein is one potential therapeutic alternative. The present study was designed assess whether cognitive deficits with ageing may partially overcome by increasing availability brain. Fischer-344×Brown...
Pulsatile release of GH was compared in young (4-5 months old) and old (18-20 male Sprague-Dawley rats using indwelling atrial cannulae. More than 57% the exhibited pulses greater 300 ng/ml plasma, whereas only 7% animals had similar amplitude. Trough values were not different between rats, but during 10.5-h sampling period, mean concentrations significantly those (175.3 +/- 20.9 vs. 70.2 7.6 ng/ml; P < 0.01). In another experiment, pituitary hypothalamic somatostatin content measured rats....
Journal Article Influence of Age and Long-term Dietary Restriction on Plasma Insulin-like Growth Factor-1 (IGF-1), IGF-1 Gene Expression, Binding Proteins Get access Charles R. Breese, Breese Department Physiology Pharmacology, Bowman Gray School Medicine, Wake Forest University Search for other works by this author on: Oxford Academic PubMed Google Scholar Rhonda L. Ingram, Ingram William E. Sonntag Gerontology, Volume 46, Issue 5, September 1991, Pages B180–B187,...
Aging promotes oxidative stress in vascular endothelial and smooth muscle cells, which contribute to the development of cardiovascular diseases. NF-E2–related factor 2 (Nrf2) is a transcription factor, activated by reactive oxygen species vasculature young animals, leading adaptive upregulation numerous detoxifying antioxidant genes. The present study was designed elucidate age-associated changes homeostatic role Nrf2-driven free radical detoxification mechanisms nonhuman primates. We found...
Leading biologists and clinicians interested in aging convened to discuss biomarkers of aging. The goals were come a consensus, construct an agenda for future research, make appropriate recommendations policy makers the public-at-large. While there was not total agreement on all issues, they addressed number questions, among them whether can be identified used measure physiological age any individual within population, given emerging information about new technological advances. hurdles...
Purpose: Pro-inflammatory environments in the brain have been implicated onset and progression of neurological disorders. In present study, we investigate hypothesis that irradiation induces regionally specific alterations cytokine gene protein expression.Materials methods: Four month old F344 × BN rats received either whole with a single dose 10 Gy γ-rays or sham-irradiation, were maintained for 4, 8, 24 h following irradiation. The mRNA expression levels pro-inflammatory mediators analysed...
Moment-to-moment adjustment of cerebral blood flow (CBF) to neuronal activity via neurovascular coupling is essential for the maintenance normal function. Increased oxidative stress that occurs with aging was shown impair coupling, which likely contributes a significant age-related decline in higher cortical function, increasing risk vascular cognitive impairment. Resveratrol polyphenolic compound exerts antiaging protective effects large vessels, but its on cerebromicrovasculature remain...
Epidemiological studies show that obesity has deleterious effects on the brain and cognitive function in elderly population. However, specific mechanisms through which aging interact to promote decline remain unclear. To test hypothesis exacerbates obesity-induced cerebromicrovascular impairment, we compared young (7 months) aged (24 high-fat diet–fed obese C57BL/6 mice. We found microvascular density both hippocampus cortex. The extent of hippocampal rarefaction impairment...
Shi, L., Adams, M. M., Long, A., Carter, C. C., Bennett, Sonntag, W. E., Nicolle, Robbins, D'Agostino, R., Jr. and Brunso-Bechtold, J. K. Spatial Learning Memory Deficits after Whole-Brain Irradiation are Associated with Changes in NMDA Receptor Subunits the Hippocampus. Radiat. Res. 166, 892–899 (2006).Whole-brain irradiation is used for treatment of brain tumors, but can it also induce neural changes, progressive dementia occurring 20–50% long-term survivors. The present study investigated...
The necessity of including both males and females in molecular neuroscience research is now well understood. However, there relatively limited basic biological data on brain sex differences across the lifespan despite age-related neurological dysfunction disease between females. Whole genome gene expression young (3 months), adult (12 old (24 months) male female C57BL6 mice hippocampus was analyzed. Subsequent bioinformatic analyses confirmations changes hippocampal protein were performed....
Hyperglycemia in diabetes mellitus promotes oxidative stress endothelial cells, which contributes to development of cardiovascular diseases. Nuclear factor erythroid 2-related factor-2 (Nrf2) is a transcription activated by that regulates expression numerous reactive oxygen species (ROS) detoxifying and antioxidant genes. This study was designed elucidate the homeostatic role adaptive induction Nrf2-driven free radical detoxification mechanisms protection under diabetic conditions. Using...