A5042577204- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Health and Disease Prevention
- Intracerebral and Subarachnoid Hemorrhage Research
- Mitochondrial Function and Pathology
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Diet and metabolism studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dietary Effects on Health
- Eicosanoids and Hypertension Pharmacology
- Optical Imaging and Spectroscopy Techniques
- Adipose Tissue and Metabolism
- Barrier Structure and Function Studies
- Nitric Oxide and Endothelin Effects
- Cancer, Hypoxia, and Metabolism
- Cerebrovascular and genetic disorders
- Biochemical effects in animals
- Telomeres, Telomerase, and Senescence
- Nutritional Studies and Diet
- Growth Hormone and Insulin-like Growth Factors
- Sirtuins and Resveratrol in Medicine
- Long-Term Effects of COVID-19
- Genetics, Aging, and Longevity in Model Organisms
University of Oklahoma Health Sciences Center
2016-2025
Semmelweis University
2019-2025
Oklahoma State University Oklahoma City
2021-2025
University of Oklahoma
2012-2025
OU Health Stephenson Cancer Center
2021-2024
Oklahoma Medical Research Foundation
2024
Oklahoma City University
2020-2023
University of Szeged
2018-2020
Adjustment of cerebral blood flow (CBF) to neuronal activity via neurovascular coupling (NVC) has an essential role in maintenance healthy cognitive function. In aging increased oxidative stress and cerebromicrovascular endothelial dysfunction impair NVC, contributing decline. There is increasing evidence showing that a decrease NAD+ availability with age plays critical range age-related cellular impairments but its impaired NVC responses remains unexplored. The present study was designed...
Hypertension in the elderly substantially contributes to cerebromicrovascular damage and promotes development of vascular cognitive impairment. Despite importance myogenic mechanism protection, it is not well understood how aging affects functional adaptation cerebral arteries high blood pressure. was induced young (3 months) aged (24 C57/BL6 mice by chronic infusion angiotensin II (AngII). In hypertensive mice, range flow autoregulation extended higher pressure values, pressure-induced tone...
Moment-to-moment adjustment of cerebral blood flow (CBF) via neurovascular coupling has an essential role in maintenance healthy cognitive function. In advanced age, increased oxidative stress and cerebromicrovascular endothelial dysfunction impair coupling, likely contributing to age-related decline higher cortical functions. There is increasing evidence showing that mitochondrial plays a critical range cellular impairments, but its uncoupling remains unexplored. This study was designed...
Abstract Chemotherapy‐induced cognitive impairment (“chemobrain”) is a frequent side‐effect in cancer survivors treated with paclitaxel (PTX). The mechanisms responsible for PTX‐induced remain obscure, and there are no effective treatments or prevention strategies. Here, we test the hypothesis that PTX induces endothelial senescence, which impairs microvascular function contributes to genesis of decline. We transgenic p16‐3MR mice, allows detection selective elimination senescent cells, (5...
Abstract Age-related cognitive impairment and dementia pose a significant global health, social, economic challenge. While Alzheimer’s disease (AD) has historically been viewed as the leading cause of dementia, recent evidence reveals considerable impact vascular (VCID), which now accounts for nearly half all cases. The Mediterranean diet—characterized by high consumption fruits, vegetables, whole grains, fish, olive oil—has widely recognized its cardiovascular benefits may also reduce risk...
Abstract Chemotherapy-related cognitive impairment, commonly referred to as “chemobrain,” significantly affects cancer survivors’ quality of life, yet its underlying mechanisms remain unclear. Most chemotherapeutic agents cannot cross the blood–brain barrier (BBB), they cause central nervous system side effects, suggesting alternative pathways toxicity. Given that these drugs interact with cerebrovascular endothelium at their highest concentrations, it is logical hypothesize endothelial...
Moment-to-moment adjustment of cerebral blood flow (CBF) to neuronal activity via neurovascular coupling is essential for the maintenance normal function. Increased oxidative stress that occurs with aging was shown impair coupling, which likely contributes a significant age-related decline in higher cortical function, increasing risk vascular cognitive impairment. Resveratrol polyphenolic compound exerts antiaging protective effects large vessels, but its on cerebromicrovasculature remain...
Epidemiological studies show that obesity has deleterious effects on the brain and cognitive function in elderly population. However, specific mechanisms through which aging interact to promote decline remain unclear. To test hypothesis exacerbates obesity-induced cerebromicrovascular impairment, we compared young (7 months) aged (24 high-fat diet–fed obese C57BL/6 mice. We found microvascular density both hippocampus cortex. The extent of hippocampal rarefaction impairment...
In rodents, moderate caloric restriction (CR) without malnutrition exerts significant cerebrovascular protective effects, improving cortical microvascular density and endothelium-dependent vasodilation, but the underlying cellular mechanisms remain elusive. To elucidate persisting effects of CR on cerebromicrovascular endothelial cells (CMVECs), primary CMVECs were isolated from young (3 mo old) aged (24 ad libitum-fed F344xBN rats. We found an age-related increase in mitochondrial oxidative...
Summary Recent studies demonstrate that aging exacerbates hypertension‐induced cognitive decline, but the specific age‐related mechanisms remain elusive. Cerebral microhemorrhages ( CMH s) are associated with rupture of small intracerebral vessels and thought to progressively impair neuronal function. To determine whether s young (3 months) aged (24 mice were treated angiotensin II plus L‐ NAME . We found same level hypertension leads significantly earlier onset increased incidence in than...
Obesity has deleterious effects on cognitive function in the elderly adults. In mice, aging exacerbates obesity-induced oxidative stress, microvascular dysfunction, blood–brain barrier (BBB) disruption, and neuroinflammation, which compromise health. However, specific mechanisms through obesity interact to remain elusive. Previously, we have shown that Nrf2 signaling plays a critical role resilience is associated with progressive promoting impairment. To test hypothesis deficiency...