A5074390948- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- scientometrics and bibliometrics research
- CRISPR and Genetic Engineering
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Cancer-related molecular mechanisms research
- Protein Tyrosine Phosphatases
- Nutritional Studies and Diet
- Cancer Immunotherapy and Biomarkers
- Consumer Attitudes and Food Labeling
- Virus-based gene therapy research
- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- Cancer Cells and Metastasis
- Hungarian Social, Economic and Educational Studies
- Advanced Proteomics Techniques and Applications
- Big Data and Digital Economy
- Doctoral Education Challenges and Solutions
Semmelweis University
2016-2025
HUN-REN Research Centre for Natural Sciences
2015-2025
Institute of Molecular Life Sciences
2020-2023
Molecular Oncology (United States)
2016
University of Girona
2016
NYU Langone Health
2016
Hungarian Academy of Sciences
2009
Abstract Cancer hallmark genes are responsible for the most essential phenotypic characteristics of malignant transformation and progression. In this study, our aim was to estimate prognostic effect established cancer in multiple distinct types. RNA-seq HTSeq counts survival data from 26 different tumor types were acquired TCGA repository. DESeq used normalization. Correlations between gene expression computed using Cox proportional hazards regression by plotting Kaplan–Meier plots. The...
ABSTRACT Cancer hallmark genes are responsible for the most essential phenotypic characteristics of malignant transformation and progression. In this study, our aim was to estimate prognostic effect established cancer in multiple distinct types. RNA-seq HTSeq counts survival data from 26 different tumor types were acquired TCGA repository. DESeq used normalization. Correlations between gene expression computed using Cox proportional hazards regression by plotting Kaplan-Meier plots. The...
Abstract Age-related cognitive impairment and dementia pose a significant global health, social, economic challenge. While Alzheimer’s disease (AD) has historically been viewed as the leading cause of dementia, recent evidence reveals considerable impact vascular (VCID), which now accounts for nearly half all cases. The Mediterranean diet—characterized by high consumption fruits, vegetables, whole grains, fish, olive oil—has widely recognized its cardiovascular benefits may also reduce risk...
Hyperthermia, the raising of tumor temperature (≥39°C), holds great promise as an adjuvant treatment for cancer therapy. This review focuses on 2 key aspects hyperthermia: its molecular and cellular effects impact immune system. Hyperthermia has profound critical biological processes. Increased temperatures inhibit DNA repair enzymes, making cells more sensitive to chemotherapy radiation. Elevated also induce cell cycle arrest trigger apoptotic pathways. Furthermore, hyperthermia modifies...
// Hajnalka Harami-Papp 1, * , Lőrinc S. Pongor 3, Gyöngyi Munkácsy 1 Gergő Horváth 2 Ádám M. Nagy Attila Ambrus Péter Hauser 3 András Szabó László Tretter Balázs Győrffy MTA TTK Lendület Cancer Biomarker Research Group, H-1117, Budapest, Hungary Semmelweis University, Department of Medical Biochemistry, H-1094, Second Pediatrics, These authors have contributed equally to this work Correspondence to: Győrffy,...
Abstract Stroke is a leading cause of morbidity and mortality worldwide, dietary patterns have emerged as significant modifiable factor in stroke prevention. The Mediterranean diet, characterized by high intake fruits, vegetables, whole grains, nuts, olive oil, fish, has been widely recognized for its cardiovascular benefits. However, specific impact on risk requires further elucidation. We conducted comprehensive meta-analysis 30 studies, including both cohort case–control designs, to...
Abstract The link between abnormal sleep duration and stroke outcomes remains contentious. This meta-analysis quantifies how both short long durations impact incidence mortality. A comprehensive search was conducted in PubMed, Web of Science, Cochrane Library, Embase, Google Scholar up to November 1, 2024, identify cohort studies evaluating outcomes. Meta-analysis performed using MetaAnalysisOnline.com a random-effects model estimate pooled hazard ratios (HRs). Results were visualized...
To date individual markers have failed to correctly predict resistance against anticancer agents in breast cancer. We used gene expression patterns attributable chemotherapy-resistant cells detect potential new biomarkers related anthracycline resistance. One of the genes, PSMB7, was selected for further functional studies and clinical validation.We contrasted profiles four pairs different human tumour cell lines their counterparts resistant doxorubicin. Observed overexpression PSMB7...
// Otília Menyhart 1 , Jan Budczies 2 Gyöngyi Munkácsy Francisco J. Esteva 3 András Szabó Teresa Puig Miquel 4 and Balázs Győrffy 1, 5 Semmelweis University 2nd Department of Pediatrics, Budapest, Hungary Institute Pathology, Charité Hospital, Berlin, Germany Clinical Cancer Center, NYU Langone Medical New York, NY, USA Terapeutics Targets Laboratory (TargetsLab), Sciences, Girona, Spain MTA TTK Lendület Biomarker Research Group, Enzymology, Correspondence to: Győrffy, email:...
No independent cross-validation of success rate for studies utilizing small interfering RNA (siRNA) gene silencing has been completed before. To assess the influence experimental parameters like cell line, transfection technique, validation method, and type control, we have to validate these in a large set studies. We utilized chip data published siRNA experiments compare methods used experiments. searched NCBI GEO samples with whole transcriptome analysis before after evaluated efficiency...
Abstract Tumor heterogeneity is a consequence of clonal evolution, resulting in fractal-like architecture with spatially separated main clones, sub-clones and single-cells. As sequencing an entire tumor not feasible, we ask the question whether there optimal clinical sampling strategy that can handle hypermutations? Here, tested effect sample size, pooling as well depth using whole-exome ovarian specimens paired normal blood samples. Our study has emphasis on application—hence compared...
Introduction PhD is the highest awarded degree offered by universities in different disciplines. Owners of a can teach at universities, start independent research and receive higher salary while further building scientific career. We examined whether publication output before has correlation with subsequent activities. Methods downloaded citation data from Hungarian Scientific Bibliography for researchers who obtained between ages 24 45. The were grouped into eleven sections. number Q1...
Clear cell renal carcinoma is the most frequent type of kidney cancer, with an increasing incidence rate worldwide. In this research, we used a proteotranscriptomic approach to differentiate normal and tumor tissues in clear (ccRCC). Using transcriptomic data patients malignant paired tissue samples from gene array cohorts, identified top genes over-expressed ccRCC. We collected surgically resected ccRCC specimens further investigate results on proteome level. The differential protein...
The identification of targets that are expressed on the cell membrane is a main goal in cancer research. Lymphocyte Antigen 6 Family Member G6D (LY6G6D) gene codes for protein mainly present surface colorectal (CRC) cells. Therapeutic strategies against this like development T engagers (TCE) currently early clinical stage. In work, we interrogated public genomic datasets including TCGA to evaluate and immunologic profile tumors with high expression LY6G6D. We used data from TCGA, among...
<p xmlns="http://www.ncbi.nlm.nih.gov/JATS1">When evaluating the publication performance of a scientist one has to consider not only difference in norms different scientific fields, but also length academic career investigated researcher. Here, our goal was establish database suitable as reference for ranking by normalizing researchers output those with same and active field. By using complete citation data 17,072 Hungarian researchers, we established framework enabling quick assessment...