A5002712288- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Estrogen and related hormone effects
- Radiopharmaceutical Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Hormonal and reproductive studies
- Vitamin D Research Studies
- Prostate Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Cancer, Hypoxia, and Metabolism
- Adenosine and Purinergic Signaling
- Peptidase Inhibition and Analysis
- Tissue Engineering and Regenerative Medicine
- Bone Tissue Engineering Materials
- Radiomics and Machine Learning in Medical Imaging
- Adipose Tissue and Metabolism
- Carbon and Quantum Dots Applications
- Gene expression and cancer classification
- Bone health and osteoporosis research
- GDF15 and Related Biomarkers
- Metabolism, Diabetes, and Cancer
- Lung Cancer Research Studies
- Caveolin-1 and cellular processes
Beth Israel Deaconess Medical Center
2014-2019
University of Delaware
2012-2019
Harvard University
2014-2017
Charité - Universitätsmedizin Berlin
2009-2012
Semmelweis University
2012
Hungarian Academy of Sciences
2012
Abstract Purpose: The CYP17A1 inhibitor abiraterone markedly reduces androgen precursors and is thereby effective in castration-resistant prostate cancer (CRPC). However, increases progesterone, which can activate certain mutant receptors (AR) identified previously flutamide-resistant tumors. Therefore, we sought to determine if treatment selects for progesterone-activated ARs. Experimental Design: AR was examined by targeted sequencing metastatic tumor biopsies from 18 patients with CRPC...
Purpose: Programmed cell death ligand-1 (PD-L1)/programmed death-1 (PD-1) blockade has been unsuccessful in prostate cancer, with poor immunogenicity and subsequent low PD-L1 expression cancer being proposed as an explanation. However, recent studies indicate that a subset of may express significant levels PD-L1. Furthermore, the androgen antagonist enzalutamide shown to upregulate preclinical models. In this study, we evaluated effect neoadjuvant deprivation therapy abiraterone acetate plus...
Primary prostate cancer can have extensive microheterogeneity, but its contribution to the later emergence of metastatic castration-resistant (mCRPC) remains unclear. In this study, we microdissected residual foci in radical prostatectomies from 18 men treated with neoadjuvant-intensive androgen deprivation therapy (leuprolide, abiraterone acetate, and prednisone) analyzed them for resistance mechanisms. Transcriptome profiling showed reduced persistent receptor (AR) activity tumors, no...
Despite decreased screening-based detection of clinically insignificant tumors, most diagnosed prostate cancers are still indolent, indicating a need for better strategies significant disease before treatment. We hypothesized that patients with detectable circulating tumor DNA (ctDNA) were more likely to harbor aggressive disease.
Abstract Purpose: The molecular features that account for the distinct histology and aggressive biological behavior of Gleason pattern 4 (Gp4) versus Gp3 prostate cancer, whether tumors progress directly to Gp4, remain be established. Experimental Design: Whole-exome sequencing transcriptome profiling laser capture–microdissected adjacent cribiform Gp4 were used determine relationship between these entities. Results: Sequencing confirmed clonal based on multiple shared genomic alterations....
1,25 dihydroxyvitamin D3 (Calcitriol), one of the active forms Vitamin D, plays a vital role not only in calcium absorption but also during neuromuscular function and regulation inflammation. Epidemiological studies suggest preventive effect Calcitriol breast, colon prostate cancer, however high concentrations are necessary. Therefore targeted biologically probes must be designed to determine distribution dynamics vitro vivo. Our probe remained stable over 2 days at 37 degrees C. When added...
ABSTRACT Despite decreased screening-based detection of clinically insignificant tumors, most diagnosed prostate cancers are still indolent, indicating a need for better strategies significant disease prior to treatment. We hypothesized that patients with detectable circulating tumor DNA (ctDNA) were more likely harbor aggressive disease. applied ultra-low pass whole genome sequencing profile cell-free from 112 localized cancer and performed targeted resequencing plasma somatic mutations...
It was hypothesized that intermittent umbilical cord occlusion (UCO) would inhibit ovine fetal breathing movements (FBM) in association with increased cerebral adenosine levels. To test this hypothesis, on two successive days during late gestation (133–134 days; term = 146 days), microdialysis samples were collected from the brains of 10 chronically instrumented sheep 2-h periods complete UCO induced every 30 min (Day 1: 2-min UCOs; Day 2: 4-min UCOs). Control fetuses (n 10) underwent no...
Quantum dots ( QD s) conjugated with 1,25 dihydroxyvitamin D3 (calcitriol) and Mucin‐1 MUC ‐1) antibodies SM 3) have been found to target inflammatory breast cancer IBC ) tumors reduce proliferation, migration, differentiation of these in mice. A physiologically‐based pharmacokinetic model has constructed optimized match experimental data for multiple s: control s, s calcitriol, both calcitriol 3 1 antibodies. The predicts continuous concentration key tissues mice distinguished by stage...
Inflammatory Breast Cancer (IBC) is arguably the most severe form of breast cancer with a very high mortality rate. IBC distinct from other forms expressing unique cell surface markers such as hypoglycosylated MUC1. However, treatment options for are limited. Calcitriol potential due to its role therapeutic in cancer. Our previous research demonstrated that calcitriol inhibits metastatic ability SUM149 line. concentration would be required treatment. This may result I serious side effects...
Vitamin D3 is an essential vitamin that has been extensively studied due to its potential role as therapeutic for many diseases, including breast cancer. Previous research indicated calcitriol, the active form of a negative effect on metastatic ability Inflammatory Breast Cancer (IBC) cells however mechanism not fully understood. The calcitriol IBC starting from cellular uptake must be investigated in order understand these effects. Calcitriol bound Quantum Dots (CalQDs) are novel...
<div>Abstract<p>Primary prostate cancer can have extensive microheterogeneity, but its contribution to the later emergence of metastatic castration-resistant (mCRPC) remains unclear. In this study, we microdissected residual foci in radical prostatectomies from 18 men treated with neoadjuvant-intensive androgen deprivation therapy (leuprolide, abiraterone acetate, and prednisone) analyzed them for resistance mechanisms. Transcriptome profiling showed reduced persistent receptor...
<p>Figure S1: Assessment for neuroendocrine features by histology and IHC; Figure S2: Scatter plots depicting relationships between the 267-gene AR activity ssGSEA score 131-gene proliferation multiple genesets; S3: Plots correlations with score, assessing GR expression; S4: Segmented read depth array CGH-style chromosomes showing alterations to cancer-related genes; S5: Euler diagrams shared distinct somatic genomic events cases 003, 007, 501, 503, 506, 507, 509, 512, 520.</p>
<p>Supplemental Methods, Figure Legends, Table References</p>
<p>Supplementary Figure S2. Read depth and SNP ratio for PTEN CHD1.</p>