A5077912586- Nitric Oxide and Endothelin Effects
- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Renin-Angiotensin System Studies
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular and exercise physiology
- Cardiac Imaging and Diagnostics
- Cardiovascular Issues in Pregnancy
- Acute Myocardial Infarction Research
- Receptor Mechanisms and Signaling
- Blood Pressure and Hypertension Studies
- Cardiac Ischemia and Reperfusion
- Neurological Disease Mechanisms and Treatments
- Cardiovascular Function and Risk Factors
- Hormonal Regulation and Hypertension
- Folate and B Vitamins Research
- Thermoregulation and physiological responses
- Cardiovascular Disease and Adiposity
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Adipose Tissue and Metabolism
- Pregnancy and preeclampsia studies
- Cardiovascular Effects of Exercise
New York Medical College
2016-2025
Semmelweis University
2016-2025
Hungarian School Sport Federation
2016-2025
GTx (United States)
2025
University of Pecs
2015-2024
Morpho (United States)
2020-2024
Hungarian Research Network
2023
Creative Commons
2023
Weatherford College
2023
Hungarian University of Sports Science
2015-2021
We aimed to elucidate the possible role of phenotypic alterations and oxidative stress in age-related endothelial dysfunction coronary arterioles. Arterioles were isolated from hearts young adult (Y, 14 weeks) aged (A, 80 male Sprague-Dawley rats. For videomicroscopy, pressure-induced tone Y A arterioles their passive diameter did not differ significantly. In A, L-NAME (a NO synthase blocker)–sensitive flow-induced dilations significantly impaired (Y: 41±8% versus A: 3±2%), which could be...
There is growing evidence that obesity has deleterious effects on the brain and cognitive function in elderly population. However, specific mechanisms through which aging interact to promote decline remain unclear. To test hypothesis exacerbates obesity-induced cerebromicrovascular damage neuroinflammation, we compared young (7 months) aged (24 high fat diet–fed obese C57BL/6 mice. Aging exacerbated systemic inflammation blood–brain barrier disruption, as indicated by increased circulating...
Hypertension in the elderly substantially contributes to cerebromicrovascular damage and promotes development of vascular cognitive impairment. Despite importance myogenic mechanism protection, it is not well understood how aging affects functional adaptation cerebral arteries high blood pressure. was induced young (3 months) aged (24 C57/BL6 mice by chronic infusion angiotensin II (AngII). In hypertensive mice, range flow autoregulation extended higher pressure values, pressure-induced tone...
Background Women with ST ‐segment–elevation myocardial infarction ( STEMI ) have higher mortality rates than men. We investigated whether sex‐related differences in timely access to care among patients may be a factor associated excess risk of early women. Methods and Results identified 6022 who had information on time symptom onset hospital presentation at 41 hospitals participating the ISACS ‐TC (International Survey Acute Coronary Syndromes Transitional Countries) registry NCT 01218776)...
We have studied the effect of changes in shear stress on diameter isolated arterioles rat cremaster muscle. The steady-state active at a constant perfusion pressure (60 mm Hg) was 80 +/- 1.2 microns. vessels' passive (Ca(2+)-free solution) 156 1.8 Changes were induced either by an increase flow (velocity) or viscosity solution. At pressure, stepwise (0-80 microliters/min 10-microliters/min steps) elicited, with delay approximately 20 seconds, gradual up to 46%. 20-microliters/min rate,...
Objective— In coronary arteries, hyperhomocysteinemia (HHcy, a known risk factor for heart disease) impairs flow-induced dilations, which can be reversed by superoxide dismutase (SOD). To evidence increased O 2 .− generation and elucidate its source, we characterized changes in activity (lucigenin chemiluminescence, hydroethidine staining) expression of arterial pro- antioxidant systems (Western blotting, immunohistochemistry, cDNA microarray, reverse-transcription polymerase chain reaction)...
The phenotypic and functional changes of coronary arteries with aging promote ischemic heart disease. We hypothesized that these alterations reflect an aging-induced proinflammatory shift in vascular regulatory mechanisms. Thus, isolated young (3-month-old) aged (25-month-old) male Fischer 344 rats the expression 96 cytokines, chemokines, their receptors were screened by a cDNA-based microarray technique. In vessels expressions tumor necrosis factor (TNF)-alpha (3.3x), interleukin (IL)-1beta...
Abstract We aimed to test the hypothesis that as a consequence of short-term daily exercise, flow (shear stress)–dependent dilation and its mediation by endothelium are altered in skeletal muscle arterioles. After initial familiarization with protocol, rats ran on treadmill once day (with gradually increasing intensity up 40 minutes 28 m/min) for ≈3 weeks (EX group); control group remained sedentary (SED group). The active (internal) diameters isolated gracilis arterioles SED EX at 80 mm Hg...
We have studied the mechanisms responsible for mediation of flow (shear stress)-induced dilation isolated arterioles rat gracilis muscle. Active diameter at a constant perfusion pressure (PP, 80 mmHg) was approximately 92 microns, while their passive (Ca(2+)-free solution) 165 microns. At PP stepwise increase in solution (PS, 0-60 microliters/min 10-microliters/min steps) elicited gradual up to 140 Flow-induced dilations were eliminated by removal endothelium (by air). Dilations...
In the presence of intact endothelium, in control conditions, calculated wall shear rate (WSR) (means +/- SE: 2,658 123 s-1; n = 21) was independent arteriolar diameter (16.2-27.2 microns; correlation coefficient: r 0.12, P greater than 0.05) cremaster muscle pentobarbital-anesthetized rats. An increase blood flow velocity (due to parallel occlusion) elicited a significant WSR (to 4,981 253 s-1) followed by delayed (6-15 s) (from: 22.5 0.6 29.5 0.8 microns), which consequently resulted...
Recent studies suggest that bone morphogenetic protein-2 (BMP-2), a transforming growth factor-beta superfamily member cytokine, plays an important role both in vascular development and pathophysiological processes, including endothelial activation is likely to contribute the of coronary atherosclerosis, yet factors regulate arterial expression BMP-2 are completely unknown. We tested hypothesis cells governed by H2O2 nuclear factor (NF)-kappaBeta-dependent pathway can be activated...
Previously we demonstrated that aging in coronary arteries is associated with proinflammatory phenotypic changes and decreased NO bioavailability, which, hypothesized, promotes vascular disease by enhancing endothelial apoptosis. To test this hypothesis characterized proapoptotic alterations the phenotype of aged (26 mo old) young (3 F344 rats. DNA fragmentation analysis TUNEL assay showed vessels there was an approximately fivefold increase number apoptotic cells. In increased expression...
Oxidative stress seems to be present in all forms of hypertension. Thus, we tested the hypothesis that high intraluminal pressure (Pi) itself, by activating vascular oxidases, elicits increased superoxide (O2*-) production interfering with flow-induced dilation.Isolated, cannulated rat femoral arterial branches were exposed vitro (for 30 minutes) normal Pi (80 mm Hg) or (160 Hg). High significantly O2*- (as measured lucigenin chemiluminescence and ethidium bromide fluorescence) impaired...
Moment-to-moment adjustment of cerebral blood flow (CBF) to neuronal activity via neurovascular coupling is essential for the maintenance normal function. Increased oxidative stress that occurs with aging was shown impair coupling, which likely contributes a significant age-related decline in higher cortical function, increasing risk vascular cognitive impairment. Resveratrol polyphenolic compound exerts antiaging protective effects large vessels, but its on cerebromicrovasculature remain...
We aimed to test the hypothesis that as a consequence of short-term daily bouts exercise control arteriolar smooth muscle by endothelium is altered. Rats ran on treadmill once day, 5 days/wk, for 2–4 wk (with gradually increasing intensity, up 26 min at 22 m/min 1% grade beginning 3rd and 38 28 2% 4th wk) while group remained sedentary (SED). Cannulated pressurized arterioles rat gracilis developed spontaneous myogenic tone, which was slightly enhanced in exercised (EX) compared with SED...