Dimitris Tousoulis

ORCID: 0000-0001-7492-4984
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About
Contact & Profiles
Research Areas
  • Cardiovascular Disease and Adiposity
  • Cardiovascular Health and Disease Prevention
  • Blood Pressure and Hypertension Studies
  • Cardiac Imaging and Diagnostics
  • Cardiovascular Function and Risk Factors
  • Lipoproteins and Cardiovascular Health
  • Cardiac Valve Diseases and Treatments
  • Coronary Interventions and Diagnostics
  • Adipokines, Inflammation, and Metabolic Diseases
  • Atherosclerosis and Cardiovascular Diseases
  • Heart Rate Variability and Autonomic Control
  • Nitric Oxide and Endothelin Effects
  • Acute Myocardial Infarction Research
  • Cerebrovascular and Carotid Artery Diseases
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Atrial Fibrillation Management and Outcomes
  • Infective Endocarditis Diagnosis and Management
  • Hormonal Regulation and Hypertension
  • Cardiac Arrhythmias and Treatments
  • Biomarkers in Disease Mechanisms
  • Liver Disease Diagnosis and Treatment
  • Cardiac pacing and defibrillation studies
  • Nutritional Studies and Diet
  • Cardiac electrophysiology and arrhythmias
  • Diabetes, Cardiovascular Risks, and Lipoproteins

Hippocration General Hospital
2016-2025

National and Kapodistrian University of Athens
2016-2025

Ippokrateio General Hospital of Thessaloniki
2020-2024

Thriasio General Hospital of Elefsina
2022

Minneapolis Heart Institute Foundation
2021-2022

Maria Cecilia Hospital
2022

Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2022

Hopital Universitaire Hedi Chaker
2022

Sotiria General Hospital
2021

Athens Medical Center
2010-2020

Early detection of vascular inflammation would allow deployment targeted strategies for the prevention or treatment multiple disease states. Because is not detectable with commonly used imaging modalities, we hypothesized that phenotypic changes in perivascular adipose tissue (PVAT) induced by could be quantified using a new computerized tomography (CT) angiography methodology. We show inflamed human vessels release cytokines prevent lipid accumulation PVAT-derived preadipocytes vitro, ex...

10.1126/scitranslmed.aal2658 article EN Science Translational Medicine 2017-07-12

Background— Adiponectin is an adipokine with potentially important roles in human cardiovascular disease states. We studied the role of adiponectin cross-talk between adipose tissue and vascular redox state patients atherosclerosis. Methods Results— The study included 677 undergoing coronary artery bypass graft surgery. Endothelial function was evaluated by flow-mediated dilation brachial vivo vasomotor studies saphenous vein segments ex vivo. Vascular superoxide (O 2 − ) endothelial nitric...

10.1161/circulationaha.112.001133 article EN Circulation 2013-04-27

Oxidative stress plays a critical role in the vascular complications of type 2 diabetes. We examined effect diabetes on NADPH oxidase human vessels and explored mechanisms this interaction. Segments internal mammary arteries (IMAs) with their perivascular adipose tissue (PVAT) thoracic were obtained from 386 patients undergoing coronary bypass surgery (127 diabetes). Type was strongly correlated hypoadiponectinemia increased oxidase–derived superoxide anions (O2˙−). The genetic variability...

10.2337/db14-1011 article EN Diabetes 2014-12-31

The cardiovascular system is significantly affected in coronavirus disease-19 (COVID-19). Microvascular injury, endothelial dysfunction, and thrombosis resulting from viral infection or indirectly related to the intense systemic inflammatory immune responses are characteristic features of severe COVID-19. Pre-existing disease load linked myocardial injury worse outcomes. vascular response cytokine production interaction between acute respiratory syndrome coronavirus-2 (SARS-CoV-2)...

10.1093/cvr/cvab298 article EN cc-by Cardiovascular Research 2021-09-11

Myocardial ischemia–reperfusion injury (MIRI) remains a challenge in the context of reperfusion procedures for myocardial infarction (MI). While early revascularization stands as gold standard mitigating injury, recent insights have illuminated paradoxical role reperfusion, giving rise to phenomenon known injury. This comprehensive review delves into intricate pathophysiological pathways involved MIRI, placing particular focus on pivotal endothelium. Beyond elucidating molecular intricacies,...

10.3390/biomedicines12040802 article EN cc-by Biomedicines 2024-04-04
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