A5072830397- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Aortic Disease and Treatment Approaches
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Aortic aneurysm repair treatments
- Coronary Artery Anomalies
- Coronary Interventions and Diagnostics
- Congenital Heart Disease Studies
- Cardiac Imaging and Diagnostics
- Cancer, Lipids, and Metabolism
- interferon and immune responses
- Lymphoma Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Cardiac Ischemia and Reperfusion
- Peroxisome Proliferator-Activated Receptors
- Immune cells in cancer
- Healthcare Policy and Management
- Adipose Tissue and Metabolism
- Healthcare cost, quality, practices
- Vascular anomalies and interventions
- Anesthesia and Neurotoxicity Research
- Cancer, Hypoxia, and Metabolism
Papworth Hospital
2003-2024
Papworth Hospital NHS Foundation Trust
2014-2024
Royal Victoria Hospital
2018-2024
University of Ulster
2018-2024
Norfolk and Norwich University Hospital
2023-2024
Norfolk and Norwich University Hospitals NHS Foundation Trust
2023-2024
University of East Anglia
2023
Norwich Research Park
2023
Barnet Enfield and Haringey Mental Health Trust
2022
John Radcliffe Hospital
2013-2020
Background— Adiponectin is an adipokine with potentially important roles in human cardiovascular disease states. We studied the role of adiponectin cross-talk between adipose tissue and vascular redox state patients atherosclerosis. Methods Results— The study included 677 undergoing coronary artery bypass graft surgery. Endothelial function was evaluated by flow-mediated dilation brachial vivo vasomotor studies saphenous vein segments ex vivo. Vascular superoxide (O 2 − ) endothelial nitric...
Oxidative stress plays a critical role in the vascular complications of type 2 diabetes. We examined effect diabetes on NADPH oxidase human vessels and explored mechanisms this interaction. Segments internal mammary arteries (IMAs) with their perivascular adipose tissue (PVAT) thoracic were obtained from 386 patients undergoing coronary bypass surgery (127 diabetes). Type was strongly correlated hypoadiponectinemia increased oxidase–derived superoxide anions (O2˙−). The genetic variability...
To explore the role of systemic inflammation in regulation adiponectin levels patients with ischemic heart disease.In a cross-sectional study 575 subjects, serum was compared between healthy coronary artery disease no/mild/severe failure (HF), and nonischemic HF. Adiponectin expression release from femoral, subcutaneous thoracic adipose tissue determined 258 additional bypass grafting. Responsiveness various human depots to interleukin-6, tumor necrosis factor-α, brain natriuretic peptide...
Left ventricular (LV) hypertrophy in aortic stenosis (AS) is characterized by reduced myocardial perfusion reserve due to coronary microvascular dysfunction. However, whether this hypoperfusion leads tissue deoxygenation unknown. We aimed assess oxygenation severe AS without obstructive artery disease, and investigate its association with energetics function. Twenty-eight patients isolated 15 controls underwent cardiovascular magnetic resonance (CMR) for assessment of (myocardial index-MPRI)...
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare cancer, and large international cooperative efforts are needed to evaluate the significance of clinical risk factors immunoarchitectural patterns (IAPs) for all stages pediatric adult patients with NLPHL.
Aortic stenosis (AS) leads to left ventricular (LV) hypertrophy and dysfunction. We hypothesized that cardiac steatosis is involved in the pathophysiology also assessed whether it reversible after aortic valve replacement.Thirty-nine patients with severe AS (symptomatic=25, asymptomatic=14) normal LV ejection fraction no significant coronary artery disease 20 age- sex-matched healthy controls underwent 1H-magnetic resonance spectroscopy imaging for determination of (myocardial triglyceride...
Little data exist regarding the potential of external stents to mitigate long-term disease progression in saphenous vein grafts. We investigated effect on graft disease.A total 184 patients undergoing isolated coronary artery bypass grafting, using an internal thoracic and at least 2 additional grafts, were enrolled 14 European centers. One was randomized stent, 1 nonstented served as control. The primary end point Fitzgibbon patency scale assessed by angiography, secondary intimal...
Background The dose of protamine required following cardiopulmonary bypass (CPB) is often determined by the heparin pre-CPB, expressed as a fixed ratio. Dosing based on mathematical models clearance postulated to improve dosing precision and coagulation. We hypothesised that 2-compartment model would thromboelastography (TEG) parameters reduce administered, relative Methods findings undertook 2-stage, adaptive randomised controlled trial, allocating 228 participants receive dosed according...
Feedback of clinical outcome data to clinicians can promote and enhance patient safety. Surgeon-specific mortality (SSMD) have been released the public for a number specialties. This implies that one individual is culpable all deaths. Debate continues about SSMD because risk-averse behaviour. In USA, improved measures derived from phase care analysis (POCMA) failure rescue (FTR) are replacing SSMD, but they not tested in Europe.Using POCMA FTR analysis, we studied hospital deaths 1558...
Since 1999 important widely publicized issues have affected morale in UK cardiothoracic (CT) surgery. Because more surgeons are needed, we sought to investigate whether these events recruitment and demographic change the specialty between 2014. We collected information on consultant CT using SCTS public portal, GMC Specialist Register NHS Annual Workforce Census via Health & Social Care Information Centre. analysed demographics of with regard country primary medical qualification ethnicity...
Mitochondrial damage-associated molecular patterns (mtDAMPs) include proteins, lipids, metabolites and DNA have various context specific immunoregulatory functions. Cell-free mitochondrial (mtDNA) is recognised via pattern recognition receptors a potent activator of the innate immune system. mtDNA elevated in circulation trauma cancer patients, however functional consequences are largely undefined. Multiple myeloma (MM) relies upon cellular interactions within bone marrow (BM)...
In a post hoc analysis of the VEST III trial, we investigated effect harvesting technique on saphenous vein graft (SVG) patency and disease progression after coronary artery bypass grafting.
Abstract Background The role of aprotinin in modern cardiac surgery is not well defined. While licensed for use isolated coronary artery bypass grafting it more commonly used cases deemed to be at an increased risk bleeding. relative efficacy, and safety profile, as compared other antifibrinolytics these high‐risk uncertain. Study Design Methods A retrospective observational study with propensity matching determine whether versus tranexamic acid reduced bleeding or transfusion requirements...
Objective The primary objective was to investigate the long-term survival of patients who underwent single-vessel coronary revascularization with minimally invasive direct artery bypass surgery or without hybrid revascularization. secondary outcome measures were repeat either by grafting percutaneous intervention and incidence myocardial infarction recurrent angina. Methods This is a retrospective study prospectively collected data procedure in our center between January 2001 December 2015....
Abstract Introduction Cardiovascular events in patients with inherited bleeding disorders are challenging to manage. The risk of secondary antithrombotic treatment must be balanced against the thrombosis haemostatic therapy. Methods Patients coronary artery bypass grafting (CABG), percutaneous intervention (PCI) or atrial fibrillation (AF) from a single centre (2010–2018) included. Results A total 11 undergoing CABG ( n = 3), PCI 5) AF 3) and diagnosis haemophilia 8), B 1), factor XI...
Diffuse cardiac amyloidosis is a significant diagnosis with poor prognosis. Isolated atrial (IAA) the most common form of caused by accumulation alpha-atrial natriuretic peptide. IAA has been associated dysrhythmia, but otherwise remains poorly characterized condition. The impact incidental on postoperative outcome following surgery not previously reported. purpose this study was to examine isolated amyloid patient outcomes surgery.A retrospective analysis performed all patients having...
Veno-venous extracorporeal membrane oxygenation (VV-ECMO) support for ARDS treatment after cardiac surgery has progressed remarkably in the last 20 years. However, one of limitations a successful recover is age, being powerful predictor mortality. In this case report we discuss 78-year-old man who underwent aortic valve and root replacement. The postoperative period was complicated by following aspiration pneumonia treated with VV-ECMO weaned 6 days. At two-year follow up, patient made an...
Background Left ventricular hypertrophy in aortic stenosis (AS) is characterised by reduced myocardial perfusion reserve due to coronary microvascular dysfunction. However, it remains unclear whether the hypoperfusion seen severe AS leads tissue deoxygenation and thus, ischemia during stress. The aim of this study was assess oxygenation patients with but no obstructive artery disease before after valve replacement (AVR).
Introduction: Minimally invasive extracorporeal circulation has developed with the aim of reducing impact adverse effects associated conventional circulation. The this study was to compare outcomes for patients undergoing coronary artery bypass grafting using minimally those performed Methods: A retrospective analysis at a single centre. 2:1 propensity matching identify control grafting. Outcomes were compared univariate analysis. Results: total 354 included in study, 118 Patients well...