A5073114849- Analytical chemistry methods development
- Heavy metals in environment
- Arsenic contamination and mitigation
- Mercury impact and mitigation studies
- Heavy Metal Exposure and Toxicity
- Radioactive element chemistry and processing
- Mass Spectrometry Techniques and Applications
- Trace Elements in Health
- Hemophilia Treatment and Research
- Environmental Toxicology and Ecotoxicology
- Marine Biology and Environmental Chemistry
- Orthopaedic implants and arthroplasty
- Selenium in Biological Systems
- Analytical Chemistry and Chromatography
- Pelvic floor disorders treatments
- Iron Metabolism and Disorders
- Chromium effects and bioremediation
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Platelet Disorders and Treatments
- Environmental Chemistry and Analysis
- Electrochemical Analysis and Applications
- Pesticide Residue Analysis and Safety
- Toxic Organic Pollutants Impact
- Fluoride Effects and Removal
Prince of Wales Hospital
2025
Supra-Regional Assay Service
2015-2024
Royal Surrey NHS Foundation Trust
2022-2024
University College London
2001-2021
The Royal Free Hospital
2001-2021
Guildford Hospital
2016-2019
Royal Surrey County Hospital
2016
Royal Cornwall Hospital Trust
2016
Duke Medical Center
2016
King's College Hospital
2015
Hemophilia B, an X-linked disorder, is ideally suited for gene therapy. We investigated the use of a new therapy in patients with disorder.We infused single dose serotype-8-pseudotyped, self-complementary adenovirus-associated virus (AAV) vector expressing codon-optimized human factor IX (FIX) transgene (scAAV2/8-LP1-hFIXco) peripheral vein six severe hemophilia B (FIX activity, <1% normal values). Study participants were enrolled sequentially one three cohorts (given high, intermediate, or...
Summary. This paper reports the findings of a global survey practice patterns for management patients with haemophilia A. A total 147 treatment centres worldwide responded to questionnaire, supplying data 16 115 From these responses, 38% (range: 25–48%) were under 18 years old. Almost half (47%) reported have mild or moderate A, 48% had severe (no inhibitor) and 5% inhibitor patients. Less than received prophylactic therapy (37%, excluding patients) 54% on‐demand treatment; remaining 9%...
This is the twenty-first annual review published in JAAS of application atomic spectrometry to chemical analysis environmental samples. In air, there ongoing development instrumentation for interrogation particles at nanometre scale. It would seem that continuing interest measurement trace levels mercury species atmosphere, particularly those emissions from point sources such as coal-fired power stations. water, elemental speciation protocols have again received considerable attention and a...
Mining activities may affect the health of miners and communities living near mining sites, these effects persist even when mine is abandoned. During processes various toxic wastes are produced released into surrounding environment, resulting in contamination air, drinking water, rivers, plants, soils. In a geochemical sampling campaign undertaken Panasqueira Mine area central Portugal, an anomalous distribution several metals arsenic (As) was identified environmental media. Several...
We demonstrate that the non-living, dried roots of water hyacinth plant [Eichhornia crassipes(Mart.) Solms] can rapidly remove arsenic from water. Atomic absorption spectrometry was used to more than 93% arsenite (As(iii)) and 95% arsenate (As(v)) were removed a solution containing 200 microg As l(-1) within 60 minutes exposure powder produced roots. No difference in removal efficiency observed between two oxidation states studied. The amount remaining found be less 10 which is WHO guideline...
A pilot study was conducted to determine the applicability of toenails as a biomarker exposure elevated environmental arsenic (As) levels. total 17 individuals were recruited for study: 8 residents living near former As mine, Devon, UK, forming exposed group, plus 9 from Nottinghamshire, with no anticipated who used comparison control group. All toenail samples thoroughly washed prior analysis and wash solutions retained determination via ICP-MS provide an indication background levels each...
The arsenic species present in a range of commercially available dried-algal food products were characterized by HPLC–ICP–MS. marine origin contain up to four dimethylarsinylribosides (1) the 8–49 ppm and some also dimethylarsinic acid (DMAA). These are easily extracted account for most burden. One sample freshwater alga Nostoc sp. was found lower concentration arsenic, 3 ppm, only 34% this extractable. extract representing 1 contained one arsenosugars samples (93%), rest being DMAA. This is...
The relationship between the total arsenic concentration and chemical speciation of in two species earthworm (Lumbricus rubellus Dendrodrilus rubidus) relation to host soil, was investigated for 13 sites varying content, including a background level garden soil former mine site at Devon Great Consols, UK. Earthworms were collected with (As range 16–12, 466 mg kg−1 dry weight) measured their (concentration 7–595 using inductively coupled plasma mass spectrometry (ICP-MS). A methanol–water...
This review covers advances in elemental speciation by a range of coupled techniques, including HPLC-ICP-MS, HPLC-HG-AFS and GC-ICP-MS.
This review covers advances in elemental speciation by a range of coupled techniques, including HPLC-ICP-MS, HPLC-HG-AFS and GC-ICP-MS.
This review covers advances in elemental speciation by a range of coupled techniques, including HPLC-ICP-MS, HPLC-HG-AFS and GC-ICP-MS.
ABSTRACT Introduction Central serous chorioretinopathy (CSCR) is a common cause of acute, monocular vision loss amongst men aged 40–50 years. Diagnosis typically multimodal, requiring advanced ophthalmic imaging. These techniques are not readily available in acute care settings. Methods We report the first case CSCR diagnosed by an emergency practitioner–performed ocular point‐of‐care ultrasonography (POCUS). Results was identified presence dome‐shaped, hypoechoic elevation neurosensory...
The practice of prophylactic treatment boys with severe haemophilia has been evaluated in our centre. Prophylaxis was started at the median age 3.7 years (range 0.4-12.7 years) 38/41 children (93%) under 17 age. Median follow-up 4.1 years). criteria primary prophylaxis according to definition by European Paediatric Network Haemophilia Management fulfilled 9/38 (24%). Although a majority [76%, 29/38] after number joint bleeds 3.5, 70% this group had clinical scores 0. Intravenous catheter...