A5030727812- Cerebrovascular and Carotid Artery Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Acute Ischemic Stroke Management
- Cardiovascular Disease and Adiposity
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Disease Prevention
- Neurological Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Dementia and Cognitive Impairment Research
- Long-Term Effects of COVID-19
- Central Venous Catheters and Hemodialysis
- Neurological Disease Mechanisms and Treatments
- Optical Imaging and Spectroscopy Techniques
- Blood Pressure and Hypertension Studies
- Diagnosis and Treatment of Venous Diseases
- Retinal Imaging and Analysis
- Peripheral Artery Disease Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Colorectal Cancer Screening and Detection
- COVID-19 Clinical Research Studies
- Vascular Procedures and Complications
- Vagus Nerve Stimulation Research
Veterans Health Administration
2007-2024
University of Oklahoma Health Sciences Center
2015-2024
OU Health
2001-2023
University of Oklahoma
2013-2021
Oklahoma City University
2013-2019
University of Tulsa
1996
Mild cognitive impairment (MCI) is a prodromal stage of dementia. Understanding the mechanistic changes from healthy aging to MCI critical for comprehending disease progression and enabling preventative intervention.
Abstract Impaired cerebrovascular function contributes to the genesis of age‐related cognitive decline. In this study, hypothesis is tested that impairments in neurovascular coupling (NVC) responses and brain network predict dysfunction older adults. Cerebromicrovascular working memory healthy young ( n = 21, 33.2±7.0 years) aged 30, 75.9±6.9 participants are assessed. To determine NVC functional connectivity (FC) during a (n‐back) paradigm, oxy‐ deoxyhemoglobin concentration changes from...
Mild cognitive impairment (MCI) is a prodromal stage to dementia, affecting up 20% of the aging population worldwide. Patients with MCI have an annual conversion rate dementia 15-20%. Thus, conditions that increase from are utmost public health concern. The COVID-19 pandemic poses significant impact on our decline as one leading complications following recovery acute infection. Recent findings suggest increases in older adults. Hence, we aim uncover mechanism for induced and progression pave...
Coated-platelets, a subset of procoagulant platelets observed on dual agonist stimulation with collagen and thrombin, support robust prothrombinase activity provide unique measure platelet thrombotic potential. Coated-platelet levels are increased in large artery stroke, higher associated early stroke recurrence, suggesting potential role for risk stratification asymptomatic patients carotid stenosis.Three-hundred twenty-nine consecutive technically adequate Doppler evaluation without or...
Advanced methods of gait research, including approaches to quantify variability, and orderliness/regularity/predictability, are increasingly used identify patients at risk for the development cognitive impairment. Cerebral small vessel disease (CSVD) is highly prevalent in older adults known contribute vascular impairment dementia (VCID). Studies preclinical models demonstrate that subclinical alterations precede CSVD-related coordination. In humans, CSVD also associates with abnormalities....
Coated-platelets are a subset of platelets with increased procoagulant potential observed upon dual agonist stimulation collagen and thrombin. These prothrombotic elevated in patients non-lacunar ischemic stroke decreased spontaneous intracerebral hemorrhage compared to controls. We now investigated coated-platelet synthesis symptomatic large-artery stenosis explored the association between levels recurrence at 3 months this population. Coated-platelet were determined 60 either acute or...
<h3>Objective:</h3> To evaluate the impact of SARS-CoV-2 infection on rate progression to dementia in patients diagnosed with MCI prior COVID-19 pandemic. <h3>Background:</h3> Older age and vascular risk factors are associated increased for developing more severe forms rates from MCI. We sought determine if affects a cohort <h3>Design/Methods:</h3> Consecutive between June 30, 2019 February 28, 2020 were identified by chart review large academic memory loss clinic. Patients followed at...
To examine the potential for coated-platelets, a subset of highly procoagulant platelets observed on dual agonist stimulation with collagen and thrombin, predicting stroke at 30 days in patients TIA.Consecutive TIA were enrolled followed up prospectively. ABCD2 scores obtained each patient. Coated-platelet levels, reported as percent cells converted to determined baseline. The primary endpoint was occurrence days. Receiver operator characteristic (ROC) analysis used calculate area under...
To examine whether ADAMTS13 activity levels measured at the time of acute SARS-CoV-2 infection predict cognitive impairment after recovery.
Mild cognitive impairment (MCI) affects nearly 20% of older adults worldwide, with no targetable interventions for prevention. COVID-19 adversely cognition, >70% Long COVID presenting complaints. Neurovascular coupling (NVC), an essential mechanism function, declines aging and is further attenuated in neurocognitive disorders. The effect on NVC responses has yet to be addressed who are vulnerable dementia progression. Participants MCI a history (COV+, N = 31) participants infection (COV- 11)...