A5101688610- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Oral Health Pathology and Treatment
- Lung Cancer Treatments and Mutations
- Enzyme Structure and Function
- Ear and Head Tumors
- Cancer Cells and Metastasis
- Tracheal and airway disorders
- Cancer Treatment and Pharmacology
- Research Data Management Practices
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Regional Economic Development and Innovation
- Mesenchymal stem cell research
- Clinical practice guidelines implementation
- Mathematical Biology Tumor Growth
- Tumors and Oncological Cases
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Advances in Oncology and Radiotherapy
- Biochemical and Molecular Research
- Boron Compounds in Chemistry
- Gene expression and cancer classification
Cornell University
2017-2021
The Ohio State University
1992-2020
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
1996-2020
Cleveland Clinic
2009
McGill University
2007
Nashville Oncology Associates
2004-2005
Institute of Social and Preventive Medicine
1996
University of California, Irvine
1995
Wayne State University
1994
Carl von Ossietzky Universität Oldenburg
1993
The optimization of a purely negative depletion, enrichment process for circulating tumor cells (CTCs) in the peripheral blood head and neck cancer patients is presented. uses red cell lysis step followed by immunomagnetic labeling, subsequent CD45 positive cells. A number relevant variables are quantified, or attempted to be which control performance process. Six different labeling combinations were evaluated as well significant difference with respect source: buffy coats purchased from Red...
A completely negative enrichment technology was used to detect circulating tumor cells, CTCs, in the peripheral blood of head and neck cancer patients. Of 32 samples, 63% contained CTCs number identified per mL collected ranged from 0 214. The final purity 1 CTC 9 total cells 20,000 being both a function performance specific enrichment. Consistent with previous reports, were positively if: (1) they nucleus based on DAPI stain, (2) stained positive for cytokeratins, (3) have high nuclei...
Cancer cells frequently exhibit uncoupling of the glycolytic pathway from TCA cycle (i.e., "Warburg effect") and as a result, often become dependent on their ability to increase glutamine catabolism. The mitochondrial enzyme Glutaminase C (GAC) helps satisfy this 'glutamine addiction' cancer by catalyzing hydrolysis glutamate, which is then converted TCA-cycle intermediate α-ketoglutarate. This makes GAC an intriguing drug target spurred molecules derived...
To identify predictors of overall survival (OS) and to stratify patients according significant prognostic variables.A retrospective study 274 consecutive with primary Oral Cavity Squamous Cell Carcinoma. Kaplan-Meier, Cox proportional hazard models, recursive partitioning analysis (RPA) were used for OS. These results further validated using National Cancer Database cohort 21 895 patients.Median OS was 3.65 years. T-classification N-classification, alcoholic beverages/week, age, adjuvant...
Research Articles| September 03 2010 Necropsy Survey of Atherosclerosis in the Jewish Population Israel: Preliminary Report Subject Area: Further Areas , Oncology Pathology and Cell Biology H. Ungar; Ungar From Department Pathology, The Hebrew University-Hadassah Medical School Hadassah-University Hospital, Jerusalem, Israel Search for other works by this author on: This Site PubMed Google Scholar A. Laufer Pathologia et Microbiologia (1961) 24 (4): 711–717. https://doi.org/10.1159/000161187...
5541 Background: OSI-774 is an inhibitor of the epidermal growth factor receptor tyrosine kinase that has activity in SCCHN. Docetaxel active SCCHN and moderate toxicity when administered on a weekly schedule. We sought to determine maximum tolerated dose (MTD) OSI-774/weekly docetaxel Methods: Patient (pt) eligibility: measurable recurrent or metastatic considered incurable by surgery radiation; ≤ 1 prior chemotherapy; ECOG performance status (PS) 2. Treatment regimen: oral daily for 28 day...
Precise reporting of surgical staging and operative data in multi-institutional protocol studies could provide a number benefits: 1) fewer cases would be discarded because inadequate data, 2) staff review time reduced, 3) there assurance that participating surgeons were performing similar operations on tumors, 4) the resulting precision stratification should improve likelihood achieving accurate comparison treatment options under study, 5) by comparing parameters with local-regional control...
Many studies have been performed to identify prognostic factors of malignant melanoma using multivariate regression models. In these models, it is generally assumed that quantitative predictors such as age or tumor thickness enter linearly into the model, they are categorized.The purpose present study investigate possible curvature (nonlinearity) 'death from MM within 5 years after diagnosis' and 'survival time avoiding known shortcomings categorizing predictors.Our analyses based on data...
5541 Background: OSI-774 is an inhibitor of the epidermal growth factor receptor tyrosine kinase that has activity in SCCHN. Docetaxel active SCCHN and moderate toxicity when administered on a weekly schedule. We sought to determine maximum tolerated dose (MTD) OSI-774/weekly docetaxel Methods: Patient (pt) eligibility: measurable recurrent or metastatic considered incurable by surgery radiation; ≤ 1 prior chemotherapy; ECOG performance status (PS) 2. Treatment regimen: oral daily for 28 day...
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