A5000420787- Pneumonia and Respiratory Infections
- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- HIV/AIDS drug development and treatment
- Tuberculosis Research and Epidemiology
- Olfactory and Sensory Function Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Fungal Infections and Studies
- HIV Research and Treatment
- Streptococcal Infections and Treatments
- Infectious Diseases and Tuberculosis
- Respiratory Support and Mechanisms
- HIV-related health complications and treatments
- Long-Term Effects of COVID-19
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Allergic Rhinitis and Sensitization
- Antimicrobial Resistance in Staphylococcus
- Intensive Care Unit Cognitive Disorders
- Bacterial Identification and Susceptibility Testing
- Legionella and Acanthamoeba research
- Polyomavirus and related diseases
- Essential Oils and Antimicrobial Activity
- Antifungal resistance and susceptibility
- Mycobacterium research and diagnosis
Centre Hospitalier Universitaire de Nice
2014-2024
Johns Hopkins Hospital
2024
Hôpital l'Archet
2008-2023
Université Côte d'Azur
2013-2023
All India Institute of Medical Sciences Rishikesh
2023
Hôpital Pasteur
2010-2023
All India Institute of Medical Sciences Raipur
2023
Institut Pasteur
2021-2022
Inserm
2020
Université Toulouse III - Paul Sabatier
2020
<h3>Importance</h3> Bronchiolitis obliterans syndrome has been associated with increased morbidity and mortality after allogeneic hematopoietic stem cell transplant (HSCT). Previous studies have suggested that azithromycin may reduce the incidence of post–lung bronchiolitis syndrome. <h3>Objective</h3> To evaluate if early administration can improve airflow decline–free survival HSCT. <h3>Design, Setting, Participants</h3> The ALLOZITHRO parallel-group trial conducted in 19 French academic...
Abstract Background With the lack of effective therapy, chemoprevention, and vaccination against SARS-CoV-2, focusing on immediate repurposing existing drugs gives hope curbing COVID-19 pandemic. A recent unbiased genomics-guided tracing SARS-CoV-2 targets in human cells identified vitamin D among three top-scoring molecules manifesting potential infection mitigation patterns. Growing pre-clinical epidemiological observational data support this assumption. We hypothesized that...
The French National Reference Center for Invasive Mycoses and Antifungals leads an active sustained nationwide surveillance program on probable proven invasive fungal diseases (IFDs) to determine their epidemiology in France. Between 2012 2018, a total of 10,886 IFDs were recorded. incidence increased slightly over time (2.16 2.36/10,000 hospitalization days, P = 0.0562) relation with increase fungemia (1.03 1.19/10,000, 0.0023), while that other remained stable. proportion ≥65-year-old...
Background COPD is a frequent and significant cause of respiratory morbidity in HIV-infected patients despite the control HIV. We aimed to analyze factors correlated with this population evaluate existence specific indicators vulnerability population. Methods Findings 623 outpatients were enrolled during one year. This was characterised by dedicated questionnaire electronic patient records. screening performed according recommended spirometric criteria. The prevalence 9.0%. Age smoking...
(1) Background: Persistent post-viral olfactory disorders (PPVOD) are estimated at 30% of patients one year after COVID-19 infection. No treatment is, to date, significantly effective on PPVOD with the exception training (OT). The main objective this work was evaluate OT efficiency post-COVID-19 PPVOD. (2) Methods: Consecutive consulting ENT department were included completing clinical examination, complete Sniffin’ Stick Test (TDI), short version Questionnaire and SF-36. Patients trained...
We report a case of pulmonary penicilliosis due to Penicillium marneffei in an immunocompetent French patient with chronic obstructive disease, who had traveled endemic countries several years before. The long interval between exposure and initial symptoms infection, relapse despite prolonged voriconazole treatment are unusual features.
As CD4/CD8 ratio inversion has been associated with non-AIDS morbidity and mortality, predictors of normalization after cART need to be studied. Here, we aimed investigate the association antiretroviral regimens within an observational cohort.We selected, from a French cohort at Nice University Hospital, HIV-1 positive treatment-naive patients who initiated between 2000 2011 <1. Association (>1) in first year was assessed using multivariate logistic regression models. Specific...
Background: One of the main symptoms COVID-19 is hyposmia or even anosmia. Olfactory identification most often affected. In addition, some cognitive disorders tend to appear following infection, particularly regarding executive functions, attention, and memory. Olfaction, especially olfactory identification, related semantic memory which manages general knowledge about world. The objective this study was determine whether impaired in case persistent post disorders. Methods: 84 patients...
Bacteremia of unknown origin (BUO) are associated with increased mortality compared to those identified sources. Microbiological data patients could help characterize an appropriate empirical antibiotic treatment before bloodcultures results available during sepsis origin. Based on the dashboard our ward that prospectively records several parameters from each hospitalization, we report 101 community-acquired BUO selected among 1989 bacteremic July 2005 April 2016, being defined by absence...
Risk factors for progressive multifocal leukoencephalopathy (PML) in individuals with human immunodeficiency virus (HIV) infection are poorly documented the era of combination antiretroviral therapy (cART).We studied HIV-1-infected aged ≥15 years who had no history PML and were prospectively followed up between 1997 2011 French Hospital Database on HIV (FHDH-ANRS CO4) cohort. Cox models used to calculate adjusted hazard ratios (HRs), focusing sub-Saharan origin, suggested be protective,...
Background: Sudden olfactory loss is a major symptom of SARS-CoV-2 infection and has negative impact on daily life quality. Almost 80% disorders regress spontaneously. No precise characterization the medium- long-term symptoms been carried out yet, apart from self-assessments. The main objective this work was to characterize persistent smell in population. Methodology: Consecutive patients consulting ENT department with post-Covid19 were included. clinical examination included an analog...
Abstract Background Staphylococcus saccharolyticus is a rarely encountered coagulase-negative, which grows slowly and its strictly anaerobic staphylococcus from the skin. It usually considered contaminant, but some rare reports have described deep-seated infections. Virulence factors remain poorly known, although, genomic analysis highlights pathogenic potential. Case presentation We report case of spondylodiscitis that followed kyphoplasty, procedure associated with low rate possible severe...
ABSTRACT Background Persistent post-viral olfactory disorders (PPVOD) are widely reported after a COVID-19 and estimate to 30% one year infection. Parosmias the main qualitative dysosmia associated with olfaction recovery. No treatment is, date, significantly efficient on PPVOD except training (OT). The objective of this work was evaluate OT efficiency post-COVID-19 PPVOD. Methods Consecutive patients consulting ENT department were included mainly clinical examination, complete Sniffin’...
Abstract Background Recent studies report very low adherence of practitioners to ATS/IDSA recommendations for the treatment nontuberculous mycobacteria pulmonary disease (NTM-PD), as well a great variability practices. Type management could impact prognosis. Methods To evaluate and prognosis patients with NTM-PD cases respect ATS recommendations, we conducted multicenter retrospective cohort study (18 sentinel sites distributed throughout France), over period six years. We collected...
ABSTRACT Background Olfactory impairment is a major sequela of SARS-CoV-2 infection and has negative impact on daily life quality. loss can be assessed in many ways but seems to little realized clinical practice. The sniffin Sticks test – 12 items (SST-12) used quick olfactory disorders screening. Its use post-covid19 situation was the main objective this work. Methodology Consecutive patients consulting ENT department with post-Covid-19 were included. examination included an analog scale...