A5071997873- Cytomegalovirus and herpesvirus research
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Parvovirus B19 Infection Studies
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Herpesvirus Infections and Treatments
- HIV Research and Treatment
- SARS-CoV-2 detection and testing
- Mycobacterium research and diagnosis
- Viral-associated cancers and disorders
- COVID-19 Clinical Research Studies
- HIV/AIDS drug development and treatment
- Dermatological and COVID-19 studies
- Animal Virus Infections Studies
- Blood groups and transfusion
- Inflammatory Bowel Disease
- Influenza Virus Research Studies
- Hepatitis Viruses Studies and Epidemiology
- HIV-related health complications and treatments
- Immunodeficiency and Autoimmune Disorders
- HIV/AIDS Research and Interventions
- Mosquito-borne diseases and control
Centre Hospitalier Universitaire de Saint-Étienne
2015-2024
Centre International de Recherche en Infectiologie
2020-2024
Université Claude Bernard Lyon 1
2015-2024
Inserm
1999-2024
Centre National de la Recherche Scientifique
2020-2024
Hôpital Nord
2012-2024
Assistance Publique – Hôpitaux de Paris
2002-2024
Hôpital Ambroise-Paré
2024
Université Jean Monnet
2010-2023
École Normale Supérieure de Lyon
2020-2023
Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and, thus, for public health policy and vaccine development COVID-19. In this study, using either live particles or retroviruses pseudotyped with S viral surface protein (Spike), we studied neutralizing antibody (nAb) response serum samples from a cohort 140 qPCR-confirmed infections, including patients mild symptoms also more severe forms, those that required intensive...
Previous studies have suggested an association between cytomegalovirus (CMV) infection and steroid-refractory inflammatory bowel disease. In this study, the use of CMV DNA load during acute flare-ups ulcerative colitis (UC) to predict resistance immunosuppressive therapy was evaluated in intestinal tissue. Forty-two consecutive patients (sex ratio M/F: 0.9, mean age: 43.6 years) hospitalized for moderate severe UC treated with IV steroids were included prospectively. A colonoscopy performed...
The Rhône-Loire metropolitan areas’ 2020/21 respiratory syncytial virus (RSV) epidemic was delayed following the implementation of non-pharmaceutical interventions (NPI), compared with previous seasons. Very severe lower tract infection incidence among infants ≤ 3 months decreased twofold, proportion cases children aged > to 5 years increased, and adults 65 were markedly reduced. NPI appeared reduce RSV burden at-risk groups, should be promoted minimise impact future outbreaks.
Human enteroviruses (HEV) are among the most common viruses infecting humans. Their circulation has been widely studied in parts of world but not sub-Saharan Africa, where poliomyelitis remains prevalent. We report here molecular characterization 98 nonpoliovirus (non-PV) HEV strains isolated from 93 randomly selected cell culture-positive supernatants stool samples collected 1997 through 2006 children with acute flaccid paralysis living Central African Republic (CAR). The isolates were...
The molecular diagnosis of respiratory infection can be performed using different commercial multiplex-based PCR kits whose performances have been previously compared individually to those conventional techniques. This study the practicability and diagnostic six CE-marked available in 2011 on French market, including 2 detecting viruses atypical bacteria (from Pathofinder Seegene companies) 4 only Abbott, Genomica, Qiagen companies). respective sensitivity, specificity, accuracy agreement...
ABSTRACT Monocytes are precursors of tissue macrophages, which major targets human immunodeficiency virus type 1 (HIV-1) infection. Although few blood monocytes infected, their resulting activation could play a key role in the pathogenesis HIV disease by modulating transendothelial migration and inducing production reactive oxygen species (ROS). ROS participate chronic inflammation, replication, apoptosis immune system cells seen HIV-infected subjects. Published data on monocyte...
Summary Background Consequences of latent cytomegalovirus ( CMV ) infection reactivation on inflammatory bowel disease IBD flare, as a flare‐worsening factor or simple bystander, are debated. Impact anti‐viral treatment course is poorly known. Aim To assess the impact patients hospitalised for flare and effect in with reactivation. Methods First, population UC from Saint‐Antoine hospital, positive blood PCR without n = 26), were compared to matched negative case–control study. Secondly,...
Abstract Background Enteroviruses (EV) cause yearly outbreaks with severe infections, particularly in young children. This study investigates EV circulation, age-distribution, and clinical presentations Europe from 2018-2023. Methods Aggregated data were requested ECDC National Focal Points for Surveillance European Non-Polio Enterovirus Network. Data included detection month, specimen type, age-group, presentation the ten most commonly reported types per year. Findings Twenty-eight...
ABSTRACT The sequencing of the VP1 hypervariable region human enterovirus (HEV) genome has become reference test for typing field isolates. This study describes a new strategy HEV at serotype level that uses reverse transcription-PCR assay targeting central part VP2 capsid protein. Two pairs primers were used to amplify fragment 584 bp (with PV-1 sequence) or it (368 bp) typing. For few strains not amplified by first PCR, seminested enhanced sensitivity (which was found be approximately 10...
In 2014, the United States (US) experienced a nationwide outbreak of enterovirus D68 (EV-D68) infection with 1,152 cases reported mainly in hospitalised children severe asthma or bronchiolitis. Following US alert, 11 laboratories French (EV) surveillance network participated an EV-D68 survey. A total 6,229 respiratory samples, collected from 1 July to 31 December were screened for resulting 212 EV-D68-positive samples. These samples corresponded 200 cases. The overall positivity rates among...
Background: Rotaviruses are the major cause of acute gastroenteritis in young children worldwide, and require careful surveillance, especially context vaccination programs. Prospective surveillance is required to monitor characterize rotavirus infections, including viral clinical data, detect emergence potentially epidemic strains. Methods: Between 2006 2009, stool samples records were collected from 2044 with diarrhea admitted pediatric emergency units 13 French university hospitals....
Immunosuppressive therapies used for treating ulcerative colitis are known to favor chronic and latent viral diseases. This study aimed at evaluating prospectively the association between colonic cytomegalovirus (CMV) reactivation anti-tumor necrosis factor (TNF) monoclonal antibodies (mabs) by comparison azathioprine (AZA) in a series of flare-ups occurring consecutive patients. A total 109 were recorded 73 patients receiving maintenance therapy anti-TNF mabs (n = 69) or AZA 40). The CMV...
This study aimed to evaluate the immunochromatographic coronavirus disease 2019 (COVID-19) speed antigen test (BioSpeedia, France) as an point-of-care (AgPOCT) detect severe acute respiratory syndrome 2 (SARS-CoV-2) infection at paediatric emergency department of University Hospital Saint-Etienne in France. Between 15 January and 28 May, 2021, children presenting with symptoms compatible COVID-19 (symptomatic group) or those requiring hospitalization for any reason (asymptomatic were...