A5025989589- Antibiotic Resistance in Bacteria
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- SARS-CoV-2 detection and testing
- Fungal and yeast genetics research
- Bacterial biofilms and quorum sensing
- Social Sciences and Governance
- Orthopedic Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Plant Disease Resistance and Genetics
- French Urban and Social Studies
- Folate and B Vitamins Research
- Synthesis of β-Lactam Compounds
- Bacillus and Francisella bacterial research
- Antifungal resistance and susceptibility
- Antibiotic Use and Resistance
- Infective Endocarditis Diagnosis and Management
- Infectious Diseases and Mycology
- Fungal Infections and Studies
- Plant Pathogens and Fungal Diseases
- Antimicrobial Peptides and Activities
- Mycorrhizal Fungi and Plant Interactions
- Dermatology and Skin Diseases
- Yeasts and Rust Fungi Studies
Université de Poitiers
2019-2024
Centre Hospitalier Universitaire de Poitiers
2019-2024
Inserm
2021-2024
Université de Limoges
2023
Pharmacologie des anti-infectieux et antibiorésistance
2022
Laboratoire de Microbiologie et Génétique Moléculaires
2017
Centre Hospitalier Universitaire de Tours
2017
Laboratoire Techniques, Territoires et Sociétés
2004
is a skin commensal microorganism commonly colonizing healthy humans. Nevertheless,
Currently, no guideline provides recommendations on the duration of empirical antimicrobial treatment (EAT) in prosthetic joint infection (PJI). The aim our study was to describe time growth bacteria involved PJI, rendering possible decreased EAT. Based a French multicentre prospective cohort study, culture data from patients with confirmed hip or knee PJI were analysed. For each patient, five samples processed. Time positivity defined as first positive medium at least one sample for...
A double ampC (AmpCG183D) and ampD (AmpDH157Y) genes mutations have been identified by whole genome sequencing in a Pseudomonas aeruginosa (PaS) that became resistant (PaR) patient treated ceftolozane/tazobactam (C/T). To precisely characterize the respective contributions of these on decreased susceptibility to C/T parallel increased imipenem (IMI), mutants were generated homologous recombination PAO1 reference strain (PAO1- AmpCG183D, PAO1-AmpDH157Y, PAO1-AmpCG183D/AmpDH157Y) PaR...
The inoculum effect (i.e., reduction in antimicrobial activity at large starting inoculum) is a phenomenon described for various pathogens. Given that limited data exist regarding of Acinetobacter baumannii, we evaluated killing A. baumannii by polymyxin B, last-resort antibiotic, several inocula and developed pharmacokinetic-pharmacodynamic (PKPD) model to capture this phenomenon. In vitro static time-kill experiments were performed using B concentrations ranging from 0.125 128 mg/L against...
Abstract Background Meyerozyma guilliermondii is a yeast species responsible for invasive fungal infections. It has high minimum inhibitory concentrations (MICs) to echinocandins, the first‐line treatment of candidemia. In this context, azole antifungal agents are frequently used. However, in recent years, number azole‐resistant strains have been described. Their mechanisms resistance currently poorly studied. Objective The aim study was consequently understand several clinical isolates M. ....
Abstract The Coronavirus pandemic unveiled the unprecedented need for diagnostic tests to rapidly detect presence of pathogens in population. Real-time RT-PCR and other nucleic acid amplification techniques are accurate sensitive molecular that necessitate positive controls. To meet this need, Twist Bioscience has developed released synthetic RNA However, is an inherently unstable molecule needing cold storage, costly shipping, resource-intensive logistics. Imagene provides a solution...
Homocysteine (Hcy) is monitored in a growing number of diseases and requires rapid reliable method to measure its concentration routine practice. We validated new mass spectrometry plasma Hcy determinate our own targeted concentrations according COFRAC (French accreditation committee) recommendations. collected the measured laboratory from 2014 2015 we compared values between different clinical groups. obtained excellent performances reproducibility, sensitivity (coefficient variation <10%)....
Since 2021, 3 variants of concern (VOC) have spread to France, causing successive epidemic waves.To describe the features Alpha, Delta and Omicron VOC circulation in Nouvelle-Aquitaine region, between February 2021 2022.Data from three university hospitals (UH) were used regional SARS-CoV-2 (RT-PCR positive rates identified VOC) as well its consequences (total number hospitalizations admissions intensive care unit). They analyzed according predominant variant compared with national data.A...