A5063925465- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Neurological diseases and metabolism
- Cholinesterase and Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Metabolism and Genetic Disorders
- Early Modern Spanish Literature
- Ubiquitin and proteasome pathways
- Biochemical Acid Research Studies
- Alzheimer's disease research and treatments
- Polyomavirus and related diseases
- Historical and Literary Analyses
- Dermatology and Skin Diseases
- Cancer and Skin Lesions
- Synthetic Organic Chemistry Methods
- Prion Diseases and Protein Misfolding
- Full-Duplex Wireless Communications
- Antenna Design and Analysis
- Folate and B Vitamins Research
- Nerve injury and regeneration
- Computational Drug Discovery Methods
- Drug Solubulity and Delivery Systems
Centre Hospitalier Universitaire de Tours
2015-2024
Université de Tours
2015-2024
Inserm
2015-2024
Hôpital Bretonneau
2008-2024
Marien Ngouabi University
2024
Laboratoire de Microbiologie et Génétique Moléculaires
2008-2023
Imagerie et Cerveau
2009-2021
Clinical Investigation Center Plurithematic Tours
2002-2019
Laboratoire de Biochimie
2009-2019
Daimler (Germany)
2019
To investigate the relation between decreased maternal food intake and risk factors for coronary heart disease in adult life.Cross sectional study.169 subjects exposed to malnutrition utero (intrauterine group) during siege of Leningrad (now St Petersburg) 1941-4; 192 born just before rationing began, (infant group); 188 concurrently with first two groups but outside area (unexposed group).Ott Institute Obstetrics Gynaecology, Petersburg.Development diabetes mellitus-obesity, blood pressure,...
Signatures from patients with both psoriasis and eczema contribute to understanding disease pathogenesis diagnosis.
Autism is a complex, largely genetic psychiatric disorder. In the majority of cases, cause autism not known, but there strong evidence for etiology. To identify candidate genes, physical mapping balanced chromosomal aberrations powerful strategy, since several genes have been characterized in numerous disorders. this study, authors analyzed reciprocal translocation arising de novo subject with and mental retardation.The performed 9q23/10q22 by fluorescent situ hybridization experiments using...
Ubiquitin (Ub)-conjugating enzymes (E2) are key in ubiquitination or Ub-like modifications of proteins. We searched for all proteins belonging to the E2 enzyme super-family seven species (Homo sapiens, Mus musculus, Drosophila melanogaster, Caenorhabditis elegans, Schizosaccharomyces pombe, Saccharomyces cerevisiae, and Arabidopsis thaliana) identify families reconstruct each family's phylogeny. Our phylogenetic analysis 207 genes led us define 17 families, with 37 genes, human genome. The...
Abstract We have previously shown higher-than-expected rates of schizophrenia in relatives patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate genetic ALS and using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, estimate correlation to be 14.3% (7.05–21.6; P =1 × 10 −4 ) polygenic risk scores explaining up 0.12% variance ( =8.4 −7 ). A...
Abstract Amyotrophic lateral sclerosis (ALS), the commonest adult-onset motor neuron disorder, is characterized by a survival span of only 2–5 years after onset. Relevant biomarkers or specific metabolic signatures would provide powerful tools for management ALS. The main objective this study was to investigate cerebrospinal fluid (CSF) lipidomic signature ALS patients mass spectrometry evaluate diagnostic and predictive values profile. We showed that (n = 40) displayed highly significant...
Abstract The biological mechanisms involved in SARS-CoV-2 infection are only partially understood. Thus we explored the plasma metabolome of patients infected with to search for diagnostic and/or prognostic biomarkers and improve knowledge metabolic disturbance this infection. We analyzed 55 45 controls by LC-HRMS at time viral diagnosis (D0). first evaluated ability predict from metabotype D0 an independent population. Next, assessed feasibility predicting disease evolution 7th 15th day....
Abstract Background: Pathophysiological mechanisms that contribute to neurodegeneration in Amyotrophic Lateral Sclerosis (ALS) include oxidative stress and inflammation. We conducted a preliminary study explore these mechanisms, discuss their link ALS, determine the feasibility of incorporating this combined analysis into current biomarkers research. Methods: enrolled 10 ALS patients controls. measured activities glutathione peroxidase, reductase, superoxyde dismutase (SOD), levels serum...
Abstract Inflammation is a major risk factor for neonatal white matter injury (NWMI), which associated with later development of cerebral palsy. Although recent studies have demonstrated maturation arrest oligodendrocyte progenitor cells (OPCs) in NWMI, the identity inflammatory mediators direct effects on OPCs has been unclear. Here, we investigated downstream pro‐inflammatory IL‐1β to induce cyclooxygenase‐2 (COX2) and prostaglandin E2 (PGE2) production matter. First, assessed COX2...
Autism spectrum disorder (ASD) is a neurodevelopmental with no clinical biomarker. The aims of this study were to characterize metabolic signature ASD and evaluate multiplatform analytical methodologies in order develop predictive tools for diagnosis disease follow-up. Urine samples analyzed using (1)H (1)H-(13)C NMR-based approaches LC-HRMS-based (ESI+ ESI- on HILIC C18 chromatography columns). Data tables obtained from the six modalities training set 46 urine (22 autistic children 24...
Pathophysiological mechanisms involved in amyotrophic lateral sclerosis (ALS) are complex and none has identified reliable markers useful routine patient evaluation. The aim of this study was to analyze the CSF patients with ALS by (1)H NMR (Nuclear Magnetic Resonance) spectroscopy order identify biomarkers early stages disease, evaluate biochemical factors ALS.CSF samples were collected from at time diagnosis without neurodegenerative diseases. One two-dimensional analyses performed...
Merkel cell polyomavirus (MCPyV) is the likely causative agent of carcinoma (MCC). However, prevalence MCPyV in non-MCC population and its possible role pathogenesis other skin cancers are not known yet.A molecular pathology study was performed 33 MCC samples age- sex-matched sun exposed tumors [12 seborrheic keratoses (SK), 11 basal carcinomas (BCC) 10 lentigo maligna melanomas (LMM)]. All were analyzed for presence MCPyV-DNA by polymerase chain reaction (PCR) Southern-Blot hybridization...