A5087077036- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
- Multiple Sclerosis Research Studies
- Neonatal Respiratory Health Research
- Preterm Birth and Chorioamnionitis
University of California, San Francisco
2017-2018
Broad Center
2017-2018
Abstract Inflammation is a major risk factor for neonatal white matter injury (NWMI), which associated with later development of cerebral palsy. Although recent studies have demonstrated maturation arrest oligodendrocyte progenitor cells (OPCs) in NWMI, the identity inflammatory mediators direct effects on OPCs has been unclear. Here, we investigated downstream pro‐inflammatory IL‐1β to induce cyclooxygenase‐2 (COX2) and prostaglandin E2 (PGE2) production matter. First, assessed COX2...
Glial support is critical for normal axon function and can become dysregulated in white matter (WM) disease. In humans, loss-of-function mutations of KCNJ10, which encodes the inward-rectifying potassium channel KIR4.1, causes seizures progressive neurological decline. We investigated Kir4.1 functions oligodendrocytes (OLs) during development, adulthood after WM injury. observed that channels localized to perinodal areas inner myelin tongue, suggesting roles juxta-axonal K+ removal....