A5015318239- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Neurogenesis and neuroplasticity mechanisms
- Preterm Birth and Chorioamnionitis
- Hypothalamic control of reproductive hormones
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Neurotoxicity Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Receptor Mechanisms and Signaling
- Infant Nutrition and Health
- Genomics and Chromatin Dynamics
- Genetics and Neurodevelopmental Disorders
- Infant Development and Preterm Care
- RNA Research and Splicing
- Congenital heart defects research
- S100 Proteins and Annexins
- Effects and risks of endocrine disrupting chemicals
- RNA regulation and disease
- Fatty Acid Research and Health
- Healthcare Systems and Practices
- Hidradenitis Suppurativa and Treatments
- Nuclear Receptors and Signaling
- Sexual Differentiation and Disorders
- Neonatal and Maternal Infections
Université Paris Cité
2015-2024
Centre de Recherche Épidémiologie et Statistique
2020-2024
Inserm
2013-2024
Sorbonne Paris Cité
2012-2024
Epigénétique et Destin Cellulaire
2015-2024
NeuroDiderot
2016-2023
Hôpital Robert-Debré
2012-2022
John Wiley & Sons (United States)
2021
Hudson Institute
2021
Centre de Recherche de l'Institut de Démographie de l'Université Paris 1
2012-2019
Microglia of the developing brain have unique functional properties but how their activation states are regulated is poorly understood. Inflammatory microglia in still-developing preterm-born infants associated with permanent neurological sequelae 9 million every year. Investigating regulators microglial across models neuroinflammation-mediated injury (mouse, zebrafish) and primary human mouse we found using analysis genes proteins that a reduction Wnt/β-catenin signalling necessary...
Abstract Inflammation is a major risk factor for neonatal white matter injury (NWMI), which associated with later development of cerebral palsy. Although recent studies have demonstrated maturation arrest oligodendrocyte progenitor cells (OPCs) in NWMI, the identity inflammatory mediators direct effects on OPCs has been unclear. Here, we investigated downstream pro‐inflammatory IL‐1β to induce cyclooxygenase‐2 (COX2) and prostaglandin E2 (PGE2) production matter. First, assessed COX2...
Preterm birth places infants in an adverse environment that leads to abnormal brain development and cerebral injury through a poorly understood mechanism known involve neuroinflammation. In this study, we integrate human mouse molecular neuroimaging data investigate the role of microglia preterm white matter damage. Using model where encephalopathy prematurity is induced by systemic interleukin-1β administration, undertake gene network analysis microglial transcriptomic response injury,...
Abstract A leading cause of preterm birth is the exposure to systemic inflammation (maternal/fetal infection), which leads neuroinflammation and white matter injury (WMI). wide range cytokines chemokines are expressed upregulated in oligodendrocytes (OLs) response numerous reports show that OLs express several receptors for immune related molecules, enable them sense react. However, role OL WMI unclear. Here, we focus our study on toll-like receptor-3 (TLR3) activated by double-strand RNA...
Preterm birth is very strongly associated with maternal/foetal inflammation and leads to permanent neurological deficits. These deficits correlate the severity of white matter injury, including maturational arrest oligodendrocytes hypomyelination. exposure causes hypothyroxinemia. As such, supplementation thyroxine (T4) seems a good candidate therapy for reducing damage in preterm infants as oligodendrocyte maturation myelination regulated by thyroid hormones. We report on model...
Abstract In the pituitary of mammals, GnRH receptor (GnRHR) plays a primary role in control reproductive function. It is further expressed hippocampus, where its function, however, not well defined. By quantitative RT-PCR analyses, we demonstrate herein that onset GnRHR gene (Gnrhr) expression rat hippocampus was unexpectedly delayed as compared to and only occurred after birth. Using previously described transgenic mouse model bearing human placental alkaline phosphatase reporter under...
Objectives In the premature newborn, perinatal inflammation mediated by microglia contributes significantly to neurodevelopmental injuries including white matter injury (WMI). Brain alters development through neuroinflammatory processes activation of homeostatic toward a pro‐inflammatory and neurotoxic phenotype. Investigating immune regulators microglial is crucial find effective strategies prevent treat WMI. Methods Ex vivo cultures mouse model WMI induced (interleukin‐1‐beta [IL‐1β]...
Abstract Prenatal inflammatory insults accompany prematurity and provoke diffuse white matter injury (DWMI), which is associated with increased risk of neurodevelopmental pathologies, including autism spectrum disorders. DWMI results from maturation arrest oligodendrocyte precursor cells (OPCs), a process that poorly understood. Here, by using validated mouse model OPC blockade, we provide the genome-wide ID card effects neuroinflammation on OPCs reveals architecture global cell fate issues...
GATA2 transcription factor and LIM homeodomain proteins Islet1 (ISL1) homeobox 3 (LHX3) are suspected to be involved in gonadotrope cell fate maintenance. The GnRH receptor gene (Gnrhr), crucial for function, is expressed the pituitary gland from embryonic day 13.5 onward, well before LH FSH β-subunits. This expression pattern together with presence of WGATAR TAAT motifs Gnrhr promoter sequences suggests involvement early factors activation. In this study, using a well-characterized...
The GnRH receptor (GnRHR) plays a central role in the development and maintenance of reproductive function mammals. Following stimulation by originating from hypothalamus, GnRHR triggers multiple signaling events that ultimately stimulate synthesis periodic release gonadotropins, luteinizing-stimulating hormone (LH) follicle-stimulating hormones (FSH) which, turn, regulate gonadal functions including steroidogenesis gametogenesis. concentration at cell surface is essential for amplitude...
G protein-coupled receptor 17 (GPR17) and the WNT pathway are critical players of oligodendrocyte (OL) differentiation acting as essential timers in developing brain to achieve fully-myelinating cells. However, whether how these two systems related each other is still unknown. Of interest, both factors dysregulated adult diseases, including white matter injury cancer, making understanding their reciprocal interactions potential importance for identifying new targets strategies myelin repair....
In mammals, activation of pituitary GnRH receptor (GnRHR) by hypothalamic increases the synthesis and secretion LH FSH, which, in turn, regulate gonadal functions. However, GnRHR gene (Gnrhr) expression is not restricted to pituitary.To gain insight into extrapituitary Gnrhr, a transgenic mouse model that expresses human placental alkaline phosphatase reporter driven rat Gnrhr promoter was created.This study shows operative two functionally related organs, pineal gland, as early embryonic...
In the central nervous system, process of myelination involves oligodendrocytes that wrap myelin around axons. Myelin sheaths are mainly composed lipids and ensure efficient conduction action potentials. Oligodendrocyte differentiation is an essential preliminary step to which, in turn, a key event neurodevelopment. Bisphenol A (BPA), ubiquitous endocrine disruptor, suspected disrupt this developmental may, thus, contribute several neurodevelopmental disorders. study, we assessed effect BPA...