A5055498496- Forensic Toxicology and Drug Analysis
- Metabolomics and Mass Spectrometry Studies
- Ocular Surface and Contact Lens
- Psychedelics and Drug Studies
- Cannabis and Cannabinoid Research
- Glaucoma and retinal disorders
- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Advanced Chemical Sensor Technologies
- Computational Drug Discovery Methods
- Sphingolipid Metabolism and Signaling
- Plant biochemistry and biosynthesis
- Molecular Sensors and Ion Detection
- Olfactory and Sensory Function Studies
- Salivary Gland Disorders and Functions
- Drug-Induced Adverse Reactions
- Effects and risks of endocrine disrupting chemicals
- Antibiotics Pharmacokinetics and Efficacy
- Poisoning and overdose treatments
- Neurological and metabolic disorders
- Essential Oils and Antimicrobial Activity
- Biochemical Analysis and Sensing Techniques
- Pesticide Exposure and Toxicity
- Lipid Membrane Structure and Behavior
- Nuts composition and effects
Sorbonne Paris Cité
2022-2025
Université Paris Cité
2020-2025
Inserm
2020-2025
Assistance Publique – Hôpitaux de Paris
2022-2025
Hôpital Lariboisière
2022-2025
Centre National de la Recherche Scientifique
2020-2024
Centre Hospitalier Universitaire de Lille
2024
Hôpital Fernand-Widal
2023-2024
Institut de la Vision
2020-2023
Sorbonne Université
2020-2023
Metabolomics in clinical toxicology aim at reliably identifying and semi-quantifying a broad array of endogenous exogenous metabolites using dedicated analytical methods. Here, we developed three-step-based workflow to investigate the metabolic impact antidepressant drug venlafaxine poisoned patient who life-threatening cardiac failure managed with extracorporeal membrane oxygenation. Both targeted quantitative untargeted semi-quantitative metabolomic analyses liquid chromatography...
Synthetic cannabinoids remain one of the most important groups new psychoactive substances and are responsible for many cases poisoning in Europe. Deaths from acute 4F-MDMB-BICA have recently been reported. Severe poisonings may be underreported because is not routinely screened forensic toxicology laboratories. We report case a young man France who presented with after orally consuming powdered substance sold online as an opioid. The coma required intensive care unit management emergent...
Identification of xenobiotics and their phase I/II metabolites in poisoned patients remains challenging. Systematic approaches using bioinformatic tools are needed to detect all compounds as exhaustively possible. Here, we aimed assess an analytical workflow liquid chromatography coupled high-resolution mass spectrometry with data processing based on a molecular network identify tramadol urine plasma patients. The generated from tandem acquired both positive negative ion modes allowed for...
This study aimed to investigate the human proteome profile of samples collected from whole (W) Schirmer strips (ScS) and their two parts-the bulb (B) rest strip (R)-with a comprehensive proteomic approach using trapped ion mobility mass spectrometer, timsTOF Pro. Eight ScS were healthy subjects at four different visits be separated into three batches, i.e., 4W, 4B, 4R. In total, 1582 proteins identified in W, B, R batches. Among all proteins, binding (43.4%) those with catalytic activity...
In toxicology, screenings are routinely performed using chromatographic methods coupled to detection systems such as high-resolution mass spectrometry (HR/MS). The increase in specificity and sensitivity of HRMS is responsible for the development alternative samples Volumetric Adsorptive Micro-Sampling. Whole blood overloaded with 90 drugs was sampled 20 µL MitraTM optimize pre-analytical step well determine identification limits drugs. Elution chemicals carried out a solvent mixture through...
Annotation of lipids in untargeted lipidomic analysis remains challenging and a systematic approach needs to be developed organize important datasets with the help bioinformatic tools. For this purpose, we combined tandem mass spectrometry-based molecular networking retention time (tR) prediction annotate phospholipid sphingolipid species. Sixty-five standard compounds were used establish fragmentation rules each lipid class studied define parameters governing their chromatographic behavior....
The comprehensive detection of new psychoactive substances, including synthetic cannabinoids along with their associated metabolites in biological samples, remains an analytical challenge. To detect these chemicals, untargeted approaches using appropriate bioinformatic tools such as molecular networks are useful, albeit it necessitates a prerequisite the identification node interest within cluster. illustrate it, we reported this study and some seized e-liquid, urine, hair collected from...
Phlorotannins are polyphenols occurring exclusively in some species of brown algae, known for numerous biological activities, e.g., antioxidant, antiproliferative, antidiabetic, and antiallergic properties. Their effects on the response human lung cells to benzo[a]pyrene (B[a]P) has not been characterized. Our objective was vitro evaluate a phlorotannin-rich extract obtained from algae Ascophyllum nodosum Fucus vesiculosus B[a]P cytotoxic effects. The A549 cell line incubated with 48 72 h...
With recent evolution of cannabis legalization around the world, edibles are booming, and determining their concentration in Δ9-tetrahydrocannabinol (Δ9-THC), regulated psychoactive substance, remains a challenge for toxicology laboratories, which must prove whether product has legal status or not. Cannabinoids large family structurally similar lipophilic molecules, requiring dedicated pre-analytical methods, as well efficient chromatographic separation to differentiate cannabinoid isomers...
In the central nervous system, process of myelination involves oligodendrocytes that wrap myelin around axons. Myelin sheaths are mainly composed lipids and ensure efficient conduction action potentials. Oligodendrocyte differentiation is an essential preliminary step to which, in turn, a key event neurodevelopment. Bisphenol A (BPA), ubiquitous endocrine disruptor, suspected disrupt this developmental may, thus, contribute several neurodevelopmental disorders. study, we assessed effect BPA...
P-glycoprotein (P-gp) is an efflux transporter involved in the bioavailability of many drugs currently on market. P-gp responsible for several drug-drug interactions encountered clinical practice leading to iatrogenic hospital admissions, especially polypharmacy situations. ABCB1 genotyping only reflects indirect estimate activity. Therefore, it would be useful identify endogenous biomarkers determine phenotype predict vivo activity prior initiation treatment and assess effects The objective...