A5084218345- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Pharmacogenetics and Drug Metabolism
- Biochemical and Molecular Research
- Renal Diseases and Glomerulopathies
- Acute Lymphoblastic Leukemia research
- Genetic factors in colorectal cancer
- Chronic Lymphocytic Leukemia Research
- Drug Transport and Resistance Mechanisms
- Lung Cancer Treatments and Mutations
- Childhood Cancer Survivors' Quality of Life
- Adolescent and Pediatric Healthcare
- Cancer therapeutics and mechanisms
- Colorectal Cancer Screening and Detection
- Renal Transplantation Outcomes and Treatments
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Pharmacological Effects and Toxicity Studies
- Drug-Induced Hepatotoxicity and Protection
- Celiac Disease Research and Management
- Blood Coagulation and Thrombosis Mechanisms
- Pain Mechanisms and Treatments
- Neonatal Health and Biochemistry
- HIV/AIDS drug development and treatment
- Protease and Inhibitor Mechanisms
Université Paris Cité
2014-2024
Hôpital Européen Georges-Pompidou
2015-2024
Inserm
2011-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Centre National de la Recherche Scientifique
2009-2024
Centre de Recherche des Cordeliers
2022-2024
La Ligue Contre le Cancer
2024
Sorbonne Université
2024
Hôpital Européen
2013-2023
Délégation Paris 5
2010-2019
Objective The aim of this work was to study simultaneously the expression profile 23 CYP mRNAs CYP1, CTP2 and CYP3 families in 22 different human tissues namely adrenal gland, bladder, bone marrow, colon, fetal liver, heart, kidney, lung, mammary ovary, placenta, prostate, salivary skeletal muscle, small intestine, spleen, testis, thymus, thyroid, trachea uterus. Methods Analysis mRNA levels each these isoforms performed on total RNA from pooled specimens organs using reverse...
Irinotecan is a major drug in the treatment of advanced colorectal cancer. Its active form SN38 metabolite, which cleared by biliary route after glucuronidation uridine diphosphate-glucuronosyltransferase 1A1 (UGT1A1). UGT1A1 activity exhibits wide intersubject variability, part related to gene polymorphisms. The present review on impact deficient UGT1A1*28 variant irinotecan efficacy and toxicity was produced French joint workgroup comprising Group Clinical Onco-pharmacology...
Identifying predictive biomarkers of drug response is key importance to improve therapy management and selection in cancer therapy. To date, the influence exposure pharmacogenetic variants on sorafenib-induced toxicity remains poorly documented. The aim this pharmacokinetic/pharmacodynamic (PK/PD) study was investigate relationship between early or unselected adult outpatients treated with single-agent sorafenib for advanced solid tumors.Toxicity recorded 54 patients days 15 30 after...
Pretherapeutic screening for dihydropyrimidine dehydrogenase (DPD) deficiency is recommended or required prior to the administration of fluoropyrimidine-based chemotherapy. However, best strategy identify DPD-deficient patients remains elusive.Among a nationwide cohort 5886 phenotyped with cancer who were screened DPD over 3 years period, we assessed characteristics both phenotypes and DPYD genotypes in subgroup 3680 had completed two tests. The extent which defective allelic variants...
TPMT activity and metabolite determination (6-thioguanine nucleotides [6-TGN] 6-methylmercaptopurine [6-MMPN]) remain controversial during thiopurine management. This study assessed associations between patient characteristics activity, their impact on levels.A retrospective review of the laboratory database from a French university hospital identified 7360 patients referred for phenotype/genotype determination, and/or 6-TGN/6-MMPN monitoring.Four phenotypes were according to distribution:...
In African-American patients with sickle cell disease (SCD), APOL1 G1 and G2 variants are associated increased risk of nephropathy (SCN). To determine the role in SCD living Europe, we genotyped 152 [aged 30·4 (24·3-36·4) years], mainly Sub-Saharan African ancestry, for four genes kidney tropism (GSTM1, GSTT1, GSTP1, HMOX1). Homozygous or double-heterozygous APOL genotypes were strongly end stage renal (P = 0·003) worse Kidney Disease: Improving Global Outcomes stages 0·001). Further, these...
High interindividual variability (IIV) of the clinical response to epidermal growth factor receptor (EGFR) inhibitors such as osimertinib in non-small-cell lung cancer (NSCLC) might be related IIV plasma exposure. The aim this study was evaluate exposure−response relationship for toxicity and efficacy unselected patients with advanced EGFR-mutant NSCLC. This retrospective analysis included 87 treated osimertinib. Exposure−toxicity performed entire cohort survival only second-line (n = 45)....
Determining dihydropyrimidine dehydrogenase (DPD) activity by measuring patient's uracil (U) plasma concentration is mandatory before fluoropyrimidine (FP) administration in France. In this study, we aimed to refine the pre-analytical recommendations for determining U and dihydrouracil (UH2 ) concentrations, as they are essential reliable DPD-deficiency testing.U UH2 concentrations were collected from 14 hospital laboratories. Stability whole blood after centrifugation, type of anticoagulant...
We have investigated in vitro the metabolic capability of 3 extrahepatic cytochromes P-450, CYP1A1, 1B1 and 2J2, known to be over-expressed various tumors, biotransform 5 tyrosine kinase inhibitors (TKI): dasatinib, imatinib, nilotinib, sorafenib sunitinib. Moreover, mRNA expression 1B1, 2J2 3A4 6 hepatocellular 14 renal cell carcinoma tumor tissues their surrounding healthy tissues, was determined. Our results show that especially can rapidly studied TKIs with a efficiency similar CYP3A4....
Aims Cytidine deaminase (CDA) activity in cancer patients' serum has been proposed as a predictive biomarker for efficacy and toxicity of nucleoside analogues. However, discrepant results about its value have reported due to the high interindividual variability CDA activity. This study aimed at identifying determinants this variability. Methods From December 2014 November 2015, 183 patients were prospectively included. Serum activity, biological clinical characteristics well five common...
Lipin-1 deficiency is a life-threatening disease that causes severe rhabdomyolysis (RM) and chronic symptoms associated with oxidative stress. In the absence of treatment, Hydroxychloroquine sulfate (HCQ) was administered to patients off label use on compassionate basis in order improve their physical conditions.Eleven LPIN1 mutations were treated HCQ. Clinical biological efficacy tolerance assessed, including pain quality life, capacities, cardiopulmonary parameters, creatine kinase levels...