A5060413020- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Economic and Financial Impacts of Cancer
- Renal cell carcinoma treatment
- COVID-19 and healthcare impacts
- Lung Cancer Research Studies
- Prostate Cancer Treatment and Research
- Palliative Care and End-of-Life Issues
- Nutrition and Health in Aging
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Cancer, Lipids, and Metabolism
- Cancer survivorship and care
- Sarcoma Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Chronic Lymphocytic Leukemia Research
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Patient Dignity and Privacy
- Frailty in Older Adults
- Cancer, Hypoxia, and Metabolism
- Diet and metabolism studies
- Radiopharmaceutical Chemistry and Applications
Clinique Hartmann
2020-2024
Université Paris Cité
2010-2018
Délégation Paris 5
2011-2018
Hôpital Cochin
2013-2018
Assistance Publique – Hôpitaux de Paris
2010-2018
Hôpital Broca
2016
Weatherford College
2014-2015
Sorbonne Université
2015
Sorbonne Paris Cité
2011-2014
Maternité Port Royal
2014
Metastasis is a multistep process and the main cause of mortality in lung cancer patients. We previously showed that EGFR mutations were associated with copy number gain at locus encompassing TWIST1 gene on chromosome 7. highly conserved developmental involved embryogenesis may be reactivated cancers promoting both malignant conversion progression through an epithelial to mesenchymal transition (EMT). The aim this study was investigate possible implication reactivation acquisition phenotype...
Therapeutic drug monitoring (TDM) could be helpful in oral targeted therapies. Data are sparse to evaluate its impact on treatment management. This study aimed determine a threshold value of plasma exposure associated with the occurrence grade 3-4 toxicity, then potential TDM clinical decision. Consecutive outpatients treated sunitinib were prospectively monitored between days 21 and 28 first cycle, monthly until disease progression. At each consultation, composite AUCƬ,ss (sunitinib +...
Aims Cytidine deaminase (CDA) activity in cancer patients' serum has been proposed as a predictive biomarker for efficacy and toxicity of nucleoside analogues. However, discrepant results about its value have reported due to the high interindividual variability CDA activity. This study aimed at identifying determinants this variability. Methods From December 2014 November 2015, 183 patients were prospectively included. Serum activity, biological clinical characteristics well five common...
Objective This study aimed to assess the tolerance of bevacizumab (BEVA) among older ovarian cancer patients in daily clinical practice and identify a subpopulation with high risk severe adverse effects. Methods Consecutive pathologically proven high-grade serous ovarian, tubal, or peritoneal carcinoma who received BEVA between January 2006 June 2014 were included retrospective analysis. Results Among 86 BEVA-treated patients, 42 (48.8%) concomitant chemotherapy, 26 (30%) had baseline...
Abstract The cancer population seems to be more susceptible COVID‐19 infection and have worse outcomes. We had adapt our medical practice protect patients without compromising their prognosis. national PRATICOVID study aims describe the adaptation of patient care for this population. analyzed data from nine different institutions. primary endpoint was assess prevalence adapted during pandemic. secondary endpoints were point view clinicians after 435 procedures between 9 th March 30 April....
The increasing number of unfit patients calls for better risk assessment prior to initiating anti-tumor treatment. This is a major concern in the prevention and reduction treatment-related complications. aim our study was evaluate nutritional status qualifying receive gemcitabine oxaliplatin (GEMOX) regimen. single-center, retrospective examined baseline clinical biological characteristics cohort 165 unselected, consecutive cancer receiving GEMOX. Malnutrition defined as either body mass...
170 Background: Older age is a cause of disparity in cancer treatment decision and guidelines for patients with comorbidities, polypharmacy, denutrition or psycho-social frailty are needed. A pre-therapeutic multidimensional assessment might improve the complex patient management. We developed an experimental program integrated medicine called ARIANE. report 18 months activity this outpatient setting evaluation, its feasibility impact on decision-making. Methods: Complex predefined strategy...
TPS12148 Background: Prostate cancer is the leading among men. Advances in therapeutic techniques, personalized medicine, and integration of targeted therapies have significantly improved patient outcomes, resulting a 5-year overall survival 93%. However, effective care requires shared decision-making framework clear communication between healthcare professionals patients. The initial step involves disclosing diagnosis during dedicated consultation, laying foundation for patient-physician...