A5024658242- Heat shock proteins research
- Genetics, Aging, and Longevity in Model Organisms
- thermodynamics and calorimetric analyses
- Neonatal and fetal brain pathology
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Spaceflight effects on biology
- Endoplasmic Reticulum Stress and Disease
- Physiological and biochemical adaptations
- Adipose Tissue and Metabolism
- Ubiquitin and proteasome pathways
- Neurogenesis and neuroplasticity mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- ATP Synthase and ATPases Research
- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Cell Image Analysis Techniques
- Protein Structure and Dynamics
- RNA Research and Splicing
- Cerebral Palsy and Movement Disorders
- Pluripotent Stem Cells Research
- Congenital limb and hand anomalies
- Toxin Mechanisms and Immunotoxins
- Renal and related cancers
- Health, Medicine and Society
Epigénétique et Destin Cellulaire
2015-2024
Université Paris Cité
2014-2024
Centre National de la Recherche Scientifique
2011-2023
Sorbonne Paris Cité
2012-2023
Délégation Paris 7
2010-2020
Université Sorbonne Paris Nord
2018
École Normale Supérieure - PSL
1994-2003
Expression Génétique Microbienne
2002
Centre de Génétique Moléculaire
1999
Institut Pasteur
1987-1997
The heat shock response is a defense reaction activated by proteotoxic damage induced physiological or environmental stress. Cells respond to the elevated expression of proteins (Hsps) that function as molecular chaperones and maintain vital homeostasis protein folds. Heat factors (HSFs) are main transcriptional regulators stress-induced hsp genes. Mammalian HSF1 was originally identified regulator response, whereas HSF2 has not been implicated role in stress response. Previously, we others...
The spontaneous expression of heat shock genes during development is well documented in many animal species, but the mechanisms responsible for this developmental regulation are only poorly understood. In vertebrates, additional transcription factors, distinct from factor 1 (HSF1) involved stress response, were suggested to be control. particular, mouse HSF2 has been found active testis and preimplantation development. However, role its mechanism activation have remained elusive due paucity...
The onset of psychosis is the consequence complex interactions between genetic vulnerability to and response environmental and/or maturational changes. Epigenetics hypothesized mediate interplay genes environment leading psychosis. We believe we performed first longitudinal prospective study genomic DNA methylation during psychotic transition in help-seeking young individuals referred a specialized outpatient unit for early detection enrolled 1-year follow-up. used Infinium...
Heat-shock factors (HSFs) are associated with multiple developmental processes, but their mechanisms of action in these processes remain largely enigmatic. Hsf2 -null mice display gametogenesis defects and brain abnormalities characterized by enlarged ventricles. Here, we show that −/− cerebral cortex displays mispositioning neurons superficial layers. HSF2 deficiency resulted a reduced number radial glia fibers, the architectural guides for migrating neurons, Cajal-Retzius cells, which...
Heat shock response is characterized by the induction of heat proteins (HSPs), which facilitate protein folding, and non-HSP with diverse functions, including degradation, regulated factors (HSFs). HSF1 a master regulator HSP expression during in mammals, as HSF3 avians. HSF2 plays roles development brain reproductive organs. However, fundamental vertebrate cells have not been identified. Here we find that activated physiological range. deficiency reduces threshold for chicken or mouse...
Maintenance of protein homeostasis, through inducible expression molecular chaperones, is essential for cell survival under protein-damaging conditions. The and DNA-binding activity heat shock factor 2 (HSF2), a member the transcription family, increase upon exposure to prolonged proteotoxicity. Nevertheless, specific roles HSF2 global HSF2-dependent gene profile during sustained stress have remained unknown. Here, we found that critical Strikingly, our RNA sequencing (RNA-seq) analyses...
HBE, a newly discovered enhancer element, mediates the influence of pluripotency factors and Activin/Nodal signaling on early Nodal expression in mouse embryo, controls activation later-acting enhancers.
The mouse HSP70.1 gene, which codes for a heat shock protein (hsp70), is highly transcribed at the onset of zygotic genome activation (ZGA). This expression, occurs in absence stress, then repressed. It has been claimed that this gene does not exhibit stress response until blastocyst stage. promoter contains four element (HSE) boxes are binding sites transcription factors (HSF). We have studying presence and localization HSFs, mHSF1 mHSF2, different stages embryo development. show already...
Identifying subtle phenotypic variations in cellular images is critical for advancing biological research and accelerating drug discovery. These are often masked by the inherent heterogeneity, making it challenging to distinguish differences between experimental conditions. Recent advancements deep generative models have demonstrated significant potential revealing these nuanced phenotypes through image translation, opening new frontiers molecular biology as well identification of novel...
In recent years, deep learning models have been extensively applied to biological data across various modalities. Discriminative excelled at classifying images into categories (e.g., healthy versus diseased, treated untreated). However, these are often perceived as black boxes due their complexity and lack of interpretability, limiting application in real-world contexts. research, explainability is essential: understanding classifier decisions identifying subtle differences between...
Abstract Patients carrying autosomal dominant mutations in the histone/lysine acetyl transferases CBP or EP300 develop a neurodevelopmental disorder: Rubinstein-Taybi syndrome (RSTS). The biological pathways underlying these defects remain elusive. Here, we unravel contribution of stress-responsive pathway to RSTS. We characterize structural and functional interaction between CBP/EP300 heat-shock factor 2 (HSF2), tuner brain cortical development major player prenatal stress responses...
Heat Shock Factors (HSF) form a family of transcription factors (four in mammals) which were named according to the discovery their activation by heat shock. HSFs trigger expression genes encoding Proteins (HSPs) that function as molecular chaperones, contributing establish cytoprotective state various proteotoxic stresses and pathological conditions. Increasing evidence indicates this ancient transcriptional protective program acts genome-widely performs unexpected functions absence...
Heat shock protein 27 (HSP27/HSPB1) is a stress-inducible chaperone that facilitates cancer development by its proliferative and anti-apoptotic functions. The OGX-427 antisense oligonucleotide against HSP27 has been reported to be beneficial idiopathic pulmonary fibrosis. Here we show effective in two murine models of thrombopoietin- JAKV617F-induced myelofibrosis. limits disease progression associated with reduction spleen weight, megakaryocyte expansion and, for the JAKV617F model,...
Cancer cells rely on heat shock proteins (HSPs) for growth and survival. Especially HSP90 has multiple client plays a critical role in malignant transformation, therefore different types of inhibitors are being developed. The bioactive natural compound gambogic acid (GB) is prenylated xanthone with antitumor activity, it been proposed to function as an inhibitor. However, there contradicting reports whether GB induces response (HSR), which cytoprotective cancer potentially problematic...