A5075914132- Fungal and yeast genetics research
- Chromosomal and Genetic Variations
- Nuclear Structure and Function
- Autism Spectrum Disorder Research
- Prenatal Substance Exposure Effects
- Congenital limb and hand anomalies
- Heat shock proteins research
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Genetics and Neurodevelopmental Disorders
- Birth, Development, and Health
Université Paris Cité
2021-2023
Centre National de la Recherche Scientifique
2021-2023
Epigénétique et Destin Cellulaire
2022-2023
Institut de recherche Saint-Louis
2021
Inserm
2021
Abstract Patients carrying autosomal dominant mutations in the histone/lysine acetyl transferases CBP or EP300 develop a neurodevelopmental disorder: Rubinstein-Taybi syndrome (RSTS). The biological pathways underlying these defects remain elusive. Here, we unravel contribution of stress-responsive pathway to RSTS. We characterize structural and functional interaction between CBP/EP300 heat-shock factor 2 (HSF2), tuner brain cortical development major player prenatal stress responses...
Beyond their canonical function in nucleocytoplasmic exchanges, nuclear pore complexes (NPCs) regulate the expression of protein-coding genes. Here, we have implemented transcriptomic and molecular methods to specifically address impact NPC on retroelements, which are present multiple copies genomes. We report a novel for Nup84 complex, core building block, restricting transcription LTR-retrotransposons yeast. complex-dependent repression impacts both Copia Gypsy Ty LTR-retrotransposons, all...
Abstract The reshaping of the DNA methylome landscape after prenatal alcohol exposure (PAE) has been well-documented in adult brain, therefore a long time end exposure. However, question immediate deposition or loss methylation marks neocortex, just PAE not yet directly addressed, genome widely. Using binge-drinking-like model and capture methylome, we have identified differentially methylated regions (DMRs) that are established immediately, within two hours PAE. Remarkably, these DMRs...
ABSTRACT Beyond their canonical function in nucleocytoplasmic exchanges, nuclear pore complexes (NPCs) regulate the expression of protein-coding genes. Here, we have implemented transcriptomic and molecular methods to specifically address impact NPC on retroelements, which are present multiple copies genomes. We report a novel for Nup84 complex, core building block, restricting transcription LTR-retrotransposons yeast. complex-dependent repression impacts both Copia Gypsy Ty...