A5074439437- Dementia and Cognitive Impairment Research
- Aging, Elder Care, and Social Issues
- Health, Medicine and Society
- Health disparities and outcomes
- Nutritional Studies and Diet
- Health and Wellbeing Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Migraine and Headache Studies
- Retinal Imaging and Analysis
- Health Systems, Economic Evaluations, Quality of Life
- Healthcare Systems and Practices
- Frailty in Older Adults
- Health and Well-being Studies
- Spinal Cord Injury Research
- Genetic Associations and Epidemiology
- Pituitary Gland Disorders and Treatments
- Musculoskeletal pain and rehabilitation
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Trigeminal Neuralgia and Treatments
- Peripheral Artery Disease Management
- Helicobacter pylori-related gastroenterology studies
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
Université de Bordeaux
2013-2024
Bordeaux Population Health
2012-2024
Inserm
2012-2021
Hôpital de la Timone
2021
Centre Hospitalier Universitaire de Bordeaux
2011-2018
Institut des Maladies Neurodégénératives
2017
Hôpital Pellegrin
1992-2015
Centre Hospitalier Universitaire de Nice
2015
Centre National de la Recherche Scientifique
2015
Laboratoire d'Informatique, Signaux et Systèmes de Sophia Antipolis
2015
Abstract Objective Whereas cognitive deficits are known to be detectable long before the typical symptoms of Alzheimer's disease (AD) evident, previous studies have failed determine when functioning actually begins decline dementia. Utilizing follow‐up PAQUID study, we examined emergence first clinical over a 14‐year period dementia phase AD. Methods This study relies on case–control sample selected from cohort. Of 3,777 initial subjects cohort, 350 experienced development AD during 14 years...
OBJECTIVE: To study the relationship between social and leisure activities risk of subsequent dementia in older community residents. SETTING: A cohort people aged 65 were followed‐up 1 3 years after a baseline screening (the Paquid study). PARTICIPANTS: 2040 subjects living at home Gironde (France) randomly selected followed for least years. DATA COLLECTION: Information about was collected during with an interview by psychologist. Incident cases detected first third year follow‐up screenings...
In November 1990 a nationwide survey of migraine was conducted in France on representative sample residents aged 15 years and older. The diagnosis based the International Headache Society (IHS) classification. previous study, we validated diagnostic algorithm which classifies headache sufferers as IHS migraine, “borderline” possible non-migrainous headache. overall prevalence patients with criteria present study 8.1%; another 4% were classified fact considered definite migraine. Age, gender...
Abstract We have previously shown higher-than-expected rates of schizophrenia in relatives patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate genetic ALS and using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, estimate correlation to be 14.3% (7.05–21.6; P =1 × 10 −4 ) polygenic risk scores explaining up 0.12% variance ( =8.4 −7 ). A...
To describe the positive predictive value of mild cognitive impairment (MCI) and factors associated with progression in routine practice.A retrospective cohort study was conducted from French National Alzheimer Database. Among 446,439 patients cared for participating centers between January 2009 2014, 45,386 (10.2%) were classified as having MCI 23,676 had at least one follow-up visit. Annual rate used to dementia due disease. Hazard ratios disease estimated using Cox regression model.Annual...
<h3>Importance</h3> In clinical guidelines, overt and subclinical thyroid dysfunction are mentioned as causal treatable factors for cognitive decline. However, the scientific literature on these associations shows inconsistent findings. <h3>Objective</h3> To assess cross-sectional longitudinal of baseline with function dementia. <h3>Design, Setting, Participants</h3> This multicohort individual participant data analysis assessed 114 267 person-years (median, 1.7-11.3 years) follow-up 525 222...
An epidemiological survey of self-reported memory complaints and performance [assessed with Benton''s visual-retention test (BVRT) the Wechsler paired-associates (WPAT)] was undertaken in a community sample 2,726 noninstitutionalized subjects aged 65 over living Gironde (southwestern France). A significant relationship observed between presence problems lower on BVRT WPAT. However, beyond this relationship, there discordance two evaluations, explained part by fact that correlates functioning...
OBJECTIVES: To estimate the predictive relationship between depressive symptoms and 8‐year dementia incidence in a large prospective community sample of French older adults to compare effect magnitude for men women. DESIGN: Prospective population‐based cohort with four interview waves complete vital status ascertainment. SETTING: Urban rural communities Aquitaine Region (Gironde Dordogne), southwest France. PARTICIPANTS: Three thousand seven hundred seventy‐seven aged 65 residing...
To study the relationship between board game playing and risk of subsequent dementia in Paquid cohort.A prospective population-based study.In Bordeaux area South Western France.3675 non-demented participants at baseline.The during 20 years follow-up.Among 3675 baseline, 32.2% reported regular playing. Eight-hundred forty developed follow-up. The was 15% lower players than non-players (HR=0.85, 95% CI 0.74 to 0.99; p=0.04) after adjustment on age, gender, education other confounders....
While exposure to ultraviolet radiation (UVR) is a recognized risk factor for cataract, its association more controversial with age-related macular degeneration (AMD). We report the associations of lifetime ambient UVR cataract extraction and AMD.The Alienor Study population-based study 963 residents Bordeaux (France), aged 73 years or more. Lifetime was estimated from residential history Eurosun satellite-based estimations ground UVR. It divided in three groups (lower quartile, intermediate...
Background Numerous studies have looked at the potential benefits of various nootropic drugs such as Ginkgo biloba extract (EGb761®; Tanakan®) and piracetam (Nootropyl®) on age-related cognitive decline often leading to inconclusive results due small sample sizes or insufficient follow-up duration. The present study assesses association between intake EGb761® function elderly adults over a 20-year period. Methods Findings data were gathered from prospective community-based cohort 'Paquid'....
Geriatric syndromes (GSs) are often the result of cumulative insults to multiple organ systems and considered common in older adults. However, their frequency co-occurrence not well known elderly population. This study aimed determine prevalence several GSs analyze these a general population individuals.A cross-sectional analysis 630 adults aged 75 years or participating 10-year follow-up Bordeaux sample French Three-City Study was conducted. The following 10 were assessed: physical frailty,...
Abstract Objective This study evaluated patient and treatment (galantamine other acetylcholinesterase inhibitors (AChEIs)) factors associated with the time until nursing home placement (NHP) in patients Alzheimer's disease (AD) without cerebrovascular (CVD). Methods Re‐contact follow‐up conducted 2004 of 548 who had previously participated RCTs galantamine. Time to NHP was analyzed using Kaplan‐Meier estimates Cox regression analysed NHP. Results There were 57% female subjects mean age (SE)...
<b><i>Background:</i></b> Dementia, stroke, depression, and disability are frequent in late life major causes of quality disruption family burden. Even though each these disorders relies on specific pathogenic processes, a common clinical manifestation is psychomotor slowing. <b><i>Objective:</i></b> We assessed the relevance simple marker low speed predicting several brain outcomes: dementia, Alzheimer’s disease (AD), Parkinson’s (PD),...
<h3>Importance</h3> The eye is a sensory organ that easily accessible for imaging techniques, allowing the measurement of retinal nerve fiber layer (RNFL) thickness. part central nervous system, and its neurons may be susceptible to degeneration; therefore, changes in RNFL thickness reflect microstructural volume alterations brain. <h3>Objective</h3> To explore association between peripapillary brain visual limbic networks elderly people without dementia. <h3>Design, Setting,...
In contrast to the young adult population, limited data are presently available regarding epidemiology of metabolic syndrome (MetS) and its relationship with cardiovascular disease risk in elderly. We have investigated frequency MetS association carotid artery structure an elderly free-living population.The study population consists 5585 French noninstitutionalized men women aged 65 85 years, free diabetes, who participated multicenter Three City Study underwent ultrasound examination...
Abstract Background Physical activity may decrease the risk of dementia; however, previous cohort studies seldom investigated different types physical and household activities. Our objective was to analyze links between two dementia in older people. Methods The study used data from prospective observational Three-city included 1550 community-dwelling individuals aged 72 87 without at baseline. assessed with Voorrips questionnaire. Two sub-scores were calculated assess...
To investigate the relationship between mortality and BMI in older people, taking into account other established risk factors.A total of 3,646 French community dwellers aged 65 years from PAQUID cohort study were included. Cox proportional-hazards analysis was used to assess association mortality.Death occurred 54.1% more than 13 years: 68.99% underweight (BMI <19), 52.13% obese >30), 51.66% overweight 25-30), 51.79% reference participants 22-25) died.The relative death as a function BMI,...
The free and cued selective reminding test is used to identify memory deficits in mild cognitive impairment demented patients. It allows assessing three processes: encoding, storage, recollection of verbal episodic memory.We investigated the neural correlates these processes a large cohort study. Memento enrolled 2323 outpatients presenting either with subjective decline or who underwent cognitive, structural MRI and, for subset, fluorodeoxyglucose-positron emission tomography...