A5053761632- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Health disparities and outcomes
- Nutritional Studies and Diet
- Neurological Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- Alzheimer's disease research and treatments
- Health and Wellbeing Research
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Blood Pressure and Hypertension Studies
- Advanced Neuroimaging Techniques and Applications
- Sleep and related disorders
- Retinal Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Balance, Gait, and Falls Prevention
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- Cerebrovascular and Carotid Artery Diseases
- Intergenerational Family Dynamics and Caregiving
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Obstructive Sleep Apnea Research
- Diverse Approaches in Healthcare and Education Studies
Seoul National University Bundang Hospital
2016-2025
Seoul National University
2015-2025
Catholic University of Korea
2014-2025
UNSW Sydney
2024
Kangwon National University Hospital
2021
Seoul National University Hospital
2015-2021
Wonju Severance Christian Hospital
2021
Yonsei University
2003-2021
Dongguk University
2021
Kangdong Sacred Heart Hospital
2020
To examine the prevalence and clinical characteristics of REM sleep behavior disorder (RBD) subclinical RBD in Korean elderly population.
Background: We sought to investigate the reported association between depression and severity of knee osteoarthritis symptoms stratified by radiographic quantify contribution made symptom severity. Methods: Six hundred sixty elderly Koreans (sixty-five years or older) were evaluated for on basis Kellgren-Lawrence grading system also Western Ontario McMaster Universities Osteoarthritis Index scales. Patient interviews a questionnaire that use geriatric scale conducted purpose assessing...
Abstract Background Mild cognitive impairment (MCI) is subclassified into four subtypes by the presence of in memory domain (amnestic vs nonamnestic) and number impaired domains (single multiple). However, predictive validity for outcomes these criteria diagnostic stability are questionable. Methods We investigated 140 patients with MCI who participated baseline study Korean Longitudinal Study on Health Aging completed 18‐month follow‐up evaluation (mean duration = 1.57 ± 0.24 years)....
To investigate sleep disturbances that induce cognitive changes over 4 years in nondemented elderlies.Data were acquired from a nationwide, population-based, prospective cohort of Korean elderlies (2,238 normal cognition [NC] and 655 mild impairment [MCI]). At baseline 4-year follow-up assessments, sleep-related parameters (midsleep time, duration, latency, subjective quality, efficiency, daytime dysfunction) status measured using the Pittsburgh Sleep Quality Index Consortium to Establish...
Due to an unprecedented rate of population aging, South Korea is facing a dementia epidemic. For this reason, the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) was launched in 2009 with support from Health Industry Development Institute investigate epidemiology, biopsychosocial risk factors, outcomes dementia-related conditions.The KLOSCAD first nationwide multi-center population-based prospective cohort study. In October 2010, 12,694 individuals were randomly sampled...
Abstract The classification of Alzheimer’s disease (AD) using deep learning methods has shown promising results, but successful application in clinical settings requires a combination high accuracy, short processing time, and generalizability to various populations. In this study, we developed convolutional neural network (CNN)-based AD algorithm magnetic resonance imaging (MRI) scans from patients age/gender-matched cognitively normal controls two populations that differ ethnicity education...
Abstract Background Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer’s disease (AD) and other dementias, but its prevalence not well known. We aimed to use uniform criteria better estimate SCD across international cohorts. Methods combined individual participant data 16 cohorts from 15 countries (members of the COSMIC consortium) used qualitative quantitative (Item Response Theory/IRT) harmonization techniques prevalence. Results The sample comprised 39,387...
<b><i>Background/Aims:</i></b> Knowledge of incidence rates and risk factors is essential for the development strategies to treat patients with Alzheimer's disease (AD) mild cognitive impairment (MCI). <b><i>Methods:</i></b> A subpopulation Nationwide Survey on Dementia Epidemiology (460 Korean subjects aged ≥65 years from 2 rural urban districts) was followed up 3.5 years. The age-specific estimated were identified....
<h3>Importance</h3> In clinical guidelines, overt and subclinical thyroid dysfunction are mentioned as causal treatable factors for cognitive decline. However, the scientific literature on these associations shows inconsistent findings. <h3>Objective</h3> To assess cross-sectional longitudinal of baseline with function dementia. <h3>Design, Setting, Participants</h3> This multicohort individual participant data analysis assessed 114 267 person-years (median, 1.7-11.3 years) follow-up 525 222...
<h3>Background</h3> Idiopathic REM (rapid eye movement) sleep behaviour disorder (iRBD) has been implicated in cognitive impairments, but there is little evidence about progression of dysfunction iRBD. <h3>Methods</h3> A retrospective follow-up study with patients iRBD was performed. Conversion to neurodegenerative disorders analysed by Kaplan-Meier survival analysis. Neuropsychological test results at baseline were compared between and healthy controls. 57 successfully followed up for...
<h3>Objective</h3> To investigate the effects of completed pregnancy with childbirth and incomplete without on late-life cognition risk Alzheimer disease (AD) in women. <h3>Methods</h3> Using pooled data 3,549 women provided by 2 population-based cohort studies, we conducted logistic regression analyses to examine retrospectively associations risks mild cognitive impairment AD. For dementia, also covariance Mini-Mental State Examination (MMSE) score. <h3>Results</h3> Grand multiparous who...
We developed and evaluated the effect of Multimodal Cognitive Enhancement Therapy (MCET) consisting cognitive training, stimulations, reality orientation, physical therapy, reminiscence music therapy in combination older people with mild impairment (MCI) or mi ld dementia. This study was a multi-center, double-blind, randomized, placebo-controlled, two-period cross-over (two 8-week treatment phases separated by 4-week wash-out period). Sixty-four participants MCI dementia whose Clinical...
ABSTRACT Background: Social support programs for dementia caregivers were widely used in order to reduce care burden. We investigated which types of social supports can psychological and non-psychological burdens caregivers, explored the mechanism those supports. Methods: evaluated 731 community-dwelling patients their from National Survey Dementia Care South Korea. five (emotional support, informational tangible positive interaction, affectionate support) using Medical Outcomes Study...
<h3>Importance</h3> Retinal layer thickness is hypothesized to be related cognitive function in patients with mild impairment (MCI) and Alzheimer disease (AD). However, longitudinal cohort studies of the healthy older population are scarce. <h3>Objective</h3> To investigate association between retinal future decline a community-based cohort. <h3>Design, Setting, Participants</h3> A total 430 randomly sampled community-dwelling Korean individuals 60 years or participated baseline assessment...